Cardiac disease in systemic lupus erythematosus. Prospective study of 70 patients.

A prospective two dimensional and Doppler echocardiographic study of 70 consecutive patients with systemic lupus erythematosus (SLE) and 40 controls was carried out. Forty patients (57%) were found to have echocardiographic disturbance. Valvular abnormalities were detected in 31 patients (44%) and in only two controls (5%). Mitral valve abnormalities were the most common findings (23/70 (33%)) with mild or moderate regurgitation the most frequent lesion (16% and 9% respectively). Three patients (4%) had a morphological echocardiographic pattern suggestive of non-infective verrucous vegetations affecting the mitral valve. No patient had haemodynamically significant clinical valve disease. Pericardial effusion was identified in 19 patients (27%), of whom 14 had mild and clinically silent disease. Myocardial abnormalities were found in 14 patients (20%), but clinical features of myocardial dysfunction were present in only one. Patients with antiphospholipid antibodies were found to have an increased prevalence of endocardial lesions, mainly valvular regurgitation. It is concluded that the inclusion of echocardiography in a study protocol of patients with SLE can identify an important subset of patients with cardiac abnormalities, many of which are clinically silent. In addition, the association of antiphospholipid antibodies with endocardial lesions suggests that these antibodies may have a prominent role in the pathogenetic mechanisms of heart valve disease in SLE.

Dies Irae, la seqüència perdurable : anà lisi i comparació de diferents lectures de la seqüència gregoriana en la història de la música

La seqüència gregoriana Dies Irae s'ha convertit en un material musical àmpliament utilitzat per compositors per dotar d'un significat concret a la seves obres. Però a mesura que han passat el segles es pot determinar que l'objectiu que han tingut els compositors en voler incloure una referència a aquesta seqüència ha variat notablement. En aquest treball tracto de demostrar quins canvis hi ha hagut segons l'època i el compositor, ja sigui des del punt de vista conceptual com des del punt de vista tècnic tot analitzant obres de moments i estils diferents, parant atenció a sis obres concretes que o tenen importància a causa de la seva influència o la seva singularitat. Alhora, exposo com tot això m'ha influït per compondre obres que estiguin relacionades amb el Dies Irae i amb la música al voltant de la mort.

Quinina: 470 anos de história, controvérsias e desenvolvimento

After 470 years, a history of development, international seed smuggling and scientific development that caused deep changes in our society, has reached an end. In 1638, the countess of Chinchón contracted a disease while in the Amazon rain forest and was healed by a potion used by the native inhabitants. In 1856, William H. Perkin while attempting to obtain synthetic quinine, discovered the mauveína, a molecule that changed the world. The synthesis of quinine was also the subject of a bitter controversy among two excellent scientists of the 20th century. During centuries, quinine was the only hope against malaria disease and its exploration almost extinguished the Cinchona tree.

Irradiação de micro-ondas aplicada à síntese orgânica: uma história de sucesso no Brasil

This review article shows the publications in the field of microwave irradiation published by Brazilian researchers over the past 10 years. In South America, Brazil leads the publication of articles with the use of microwave irradiation possessing a large advantage in number of articles published over the others countries. The works were divided into four major areas: Catalysis, Reactions without Solvent, Heterocycles Chemistry, Natural Products and Other, and some could be classified in more than one category.

Efeitos da história térmica nas propriedades do polímero pet: um experimento para ensino de análise térmica

Polyethilenetherephtalate (PET) is commonly used in manufacturing of beverage bottles representing a didactic appeal in thermal analysis education due to its presence in the student's day life. Additionally such polymer presents well defined thermal analytical curves and a well known thermal behavior. TGA curve is used to present the thermal stability. The thermal history effects in the thermal properties of a PET sample from a soft drink bottle are used to demonstrate the effect of different heating/cooling conditions on glass transition, melting, crystallization and crystalline degree using DSC curves.

Viisi kuukautta myöhemmin : : hajamietteitä juhlaseminaarista : Suomen Kansantietouden Tutkijain Seuran 70-vuotisjuhlaseminaari 26.10.2007 Joensuun yliopisto

Ajankohtaista

Investigando a presença da história da ciência em livros didáticos de Química Geral para o ensino superior

This paper aims at analyzing the history of science content of three general chemistry textbooks used in Brazilian universities: the translations of Kotz and Treichel's Chemistry & Chemical Reactivity, Atkins and Jones's Chemical Principles, and Garritz and Chamizo's Química. Results revealed different trends for the inclusion of history of science in chemistry teaching. Kotz & Treichel and Atkins & Jones used history mainly as curiosity and ornament. Garritz & Chamizo adopted the historical approach as one of the organizing axis of their textbook. Nevertheless, the historical content of the three textbooks may be criticized from current historiographical standpoint.

"Serpentes de Faraó": a história de uma brincadeira pirotécnica e sua aplicabilidade no ensino de princípios químicos básicos

Fun methodologies developed with alternative materials for teaching chemical reactions of carbon are interesting activities for discussing concepts of stoichiometry and thermochemistry. The decomposition of organic matter, CO2 production and coal formation can be demonstrated in the experiment "Pharaoh´s snake". This experiment is attractive since the simple combustion of sucrose generates a peculiar structure of coal. This paper proposes a simple methodology for making the sugar tablets used in the experiment and contextualizes the experimental observations with the chemical reaction of carbon which leads to coal and to the thermodynamics involving combustion processes.

Tempo dos deuses, tempo dos homens: mito e história no político de Platão

O presente artigo realiza uma exegese do grande mito cósmico do Político de Platão, no intuito de mostrar que a representação da historicidade humana por ele alegoricamente elaborada ilustra e antecipa, em um registro simbólico, algumas das soluções teóricas exploradas pelo diálogo em sua conclusão a respeito das relações entre o melhor regime e a história.

A história como sacrifício em Blaise Pascal

Este trabalho desenvolve o tema da História em Pascal, bus­cando constituí-lo por meio da noção teológica de sacrifício. No contexto pascaliano, a História só é relevante enquanto História Espiritual, a história da salvação dos homens escolhidos entre os condenados pela queda adâmica. Como tal, a História não pode ser regida pela temporalidade vivida ordinaria­mente, mas pela temporalidade da graça, que direciona todos os instantes para o ponto central, o sacrifício de Jesus Cristo. Por isso, os homens só têm esperança de salvação na medida em que se integram ao Corpo Crístico, que prossegue em sacrifício desde o início até o fim dos tempos.

História e filosofia da história na obra do jovem Friedrich Schlegel

Este artigo apresenta e comenta dois textos do jovem Friedrich Schlegel, Vom Wert des Studiums der Griechen und Römer (Sobre o valor do estudo dos gregos e romanos), de 1795/1796, e Über das Studium der griechischen Poesie (Sobre o estudo da poesia grega), de 1795, escritos antes de sua ida para Jena, em 1796, nos quais o autor elabora uma teoria original sobre a história e a filosofia da história.