Principes d'hygiène coloniale / par le Dr Georges Treille,...

Collection : Bibliothèque de la revue générale des sciences

Cours d'hygiène générale et industrielle / par le Dr A. Batailler,... et É. Tresfont,...

Collection : Bibliothèque de l'enseignement technique

Fil. dr Karin Allardt Ekelund 1.7.1969 Helsingfors

Kirje

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified >300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection.