HIV type-1 infection of the cotton rat (Sigmodon fulviventer and S. hispidus)

Cotton rats (Sigmodon hispidus and S. fulviventer) are susceptible to many viruses that infect humans (e.g., poliovirus, respiratory syncytial virus, influenza virus, adenovirus, and parainfluenza virus) and have been influential in developing therapeutic clinical intervention strategies for many viral infections of man. This study set out to determine whether cotton rats are susceptible to infection with HIV type 1 (HIV-1). Results indicate that HIV-1 does infect the cotton rat and S. fulviventer is more susceptible than S. hispidus. The virus was passaged from animal to animal for a total of three serial passages; but HIV replicated poorly in vivo, was only detectable as proviral DNA, and never exceeded one provirus per 1.8 × 105 cotton rat peripheral blood mononuclear cells. Infection induced a distinct and characteristic anti-HIV antibody response that, in some animals, included neutralizing antibodies, recognized all of the major HIV-1 antigens and the antibodies lasted out to 52 wk post-infection. Neonate S. fulviventer were not more susceptible to infection than adults. In vitro culture studies produced indirect evidence of viral replication by detection of viral gag gene RNA in reverse transcriptase–PCR assays on viral culture supernatants. Collectively, these results indicate that HIV-1 can replicate in a nontransgenic rodent and that this system may have potential as an animal model for HIV-1 infection if viral replication rates can be improved in vivo.

Lower semicontinuity of the feasible set mapping of linear systems relative to their domains

This paper deals with stability properties of the feasible set of linear inequality systems having a finite number of variables and an arbitrary number of constraints. Several types of perturbations preserving consistency are considered, affecting respectively, all of the data, the left-hand side data, or the right-hand side coefficients.

On the stability of the Motzkin representation of closed convex sets

A set is called Motzkin decomposable when it can be expressed as the Minkowski sum of a compact convex set with a closed convex cone. This paper analyzes the continuity properties of the set-valued mapping associating to each couple (C,D) formed by a compact convex set C and a closed convex cone D its Minkowski sum C + D. The continuity properties of other related mappings are also analyzed.

Behavior of different soot combustion catalysts under NOx/O2. Importance of the catalyst–soot contact

Four different catalysts (Pt/Al2O3, Ce0.8Zr0.2O2, PrO2−x and SrTiCuO3) have been investigated on a laboratory scale to evaluate their potential as diesel soot combustion catalysts under different experimental conditions, which simulate the situation found in a continuous regeneration technology trap (dual-bed configuration of catalyst and soot) or a catalyst-coated filter system (single-bed configuration, both catalyst and soot particles mixed under loose-contact mode). Under dual-bed configuration, the behavior of the catalysts towards soot combustion are very similar, despite the differences observed in the NO2 production profiles. However, under single-bed configuration, there are important differences in the soot combustion activities and in the NO2 slip profiles. The configurations chosen have an enormous impact on CO/(CO + CO2) ratios of combustion products as well. The most active catalyst under NOx + O2 is PrO2−x combining a high contribution of active oxygen-assisted soot combustion as well as high NO2 production activity along the catalytic bed.

Developing pre-service teachers’ noticing of students’ understanding of the derivative concept

This research study examines the development of the ability of pre-service teachers to notice signs of students’ understanding of the derivative concept. It analyses preservice teachers’ interpretations of written solutions to problems involving the derivative concept before and after participating in a teacher training module. The results indicate that the development of this skill is linked to pre-service teachers’ progressive understanding of the mathematical elements that students use to solve problems. We have used these results to make some suggestions for teacher training programmes.

Students’ understanding of the function-derivative relationship when learning economic concepts

The aim of this study is to characterise students’ understanding of the function-derivative relationship when learning economic concepts. To this end, we use a fuzzy metric (Chang 1968) to identify the development of economic concept understanding that is defined by the function-derivative relationship. The results indicate that the understanding of these economic concepts is linked to students’ capacity to perform conversions and treatments between the algebraic and graphic registers of the function-derivative relationship when extracting the economic meaning of concavity/convexity in graphs of functions using the second derivative.

Annual report of the secretary of the State Horticultural Society of Michigan.

1913

Conditions of labor in American industries: a summarization of the results of recent investigations

by W. Jett Lauck and Edgar Sydenstricker.

Anniversary of the Hasty Pudding Club, August 31, 1796

This manuscript seems to be a transcript of a speech given by White at a celebration of the Hasty Pudding Club's anniversary.

The immature state of the Odonata ... / by Louis Cabot.

v.8:no.1 (1881)

Mathematics notebook, ca. 1714-1718, with chronology of the reign of Augustus

The first two pages of this notebook contain a comparative chronology of the reign of Augustus, outlined in two columns. One column outlines the chronology according to ecclesiastical scholar Laurence Echard, and the other column outlines the chronology according to William Cave. The rest of the notebook contains extensive entries on the following subjects, with related rules, problems, and illustrations: fractions, decimals, arithmetical progression, geometrical progression, "disjunct proportion, or ye Golden Rule," signs and symbols, integers, geometrical definitions, and Euclidian geometry.