999 resultados para Espaço derivado


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The framework of this study was to comprehend the specific conditions surrounding the incorporation and political-economical consolidation of the state of Mato Grosso Sul to the national scenario, during the cyclic evolution of the capitalistic system as well as the role of Campo Grande in this process. The origin and evolution of Campo Grande were analyzed in the context of possible relations between urbanization, regional development and the integration of the state in the national scope. In this approach, several theoretical compatible formulations were considered as to systemic view of reality, from the complex and dynamic point of view. This implies a multi scale reasoning, associating spatial dimension to the historical one, in a theoretical- methodological effort of comprehend the logic between the general and the specific. It was possible to verity peculiarities attributed to Mato Grosso do Sul in the general laws of the capitalistic system, and instances capable of explaning the local effects of the intervention of industrial economy in the dynamic of the process analysed since colonial times, as well as the role of Campo Grande in this process, especially in relation to the economical integration of the state territory to the rest of the nation.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Dexamethasone (DEXA) is a synthetic glucocorticoid widely used in the handling of several drugs, for its proven benefits in fighting inflammation and allergies. Despite their benefits, their chronic use leads to several side effects that include changes in the body in the metabolism of carbohydrates, lipids and proteins. Moreover, being an anti-inflammatory, acts on the arachidonic acid pathway, reducing the expression of the enzyme cyclooxygenase (COX-2) and growth factor derived from the endothelium of blood vessels (VEGF) in various tissues. However, its effects on the myocardium are still uncertain. The physical training (PT), in turn, promotes effects contrary to those caused by chronic use of DEXA, however, little is known about the preventive effects of TF in the side effects of Dexa in the myocardium. Therefore, the aim of this study was to determine if the TF has the ability to prevent and/or mitigate the effects of Dexa in protein expression of COX-2 and VEGF in the myocardium. Forty animals were divided into 4 groups: sedentary control (SC), sedentary treated with Dexa (SD), trained control (TC) and Trained treated with Dexa (TD) and submitted to a protocol of physical training on the treadmill for 70 days (1 h/day-5 days per week, 60% of physical capacity) or kept sedentary. Over the past 10 days, rats were treated with Dexa (Decadron, 0.5 mg/kg per day, ip) or saline. During training the animals were weighed weekly and during treatment daily. At the end of treatment was made to measure fasting glucose levels of animals. The rats were killed with excess anesthesia and cardiac muscle was removed, weighed, homogenized, centrifuged and stored at -20° C for analysis of protein expression of VEGF and COX-2 by Western blotting technique. Treatment with dexamethasone caused a weight loss of 18% in sedentary animals and 13% in trained as well as elevated levels of fasting glucose in sedentary (88%). The TF was unable to mitigate the loss in...

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Ciência Florestal - FCA

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Pós-graduação em Letras - FCLAS

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Pós-graduação em Educação para a Ciência - FC

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)