Predator odor-induced fear in rats : a behavioral characterization and neural substrate analysis

Otto-von Guericke-Universität Magdeburg, Fakultät für Naturwissenschaften, Dissertation, 2016

Using modeling as a co-design approach in the planning process of new care environments

Current research shows a relationship between healthcare architecture and patient-related Outcomes. The planning and designing of new healthcare environments is a complex process; the needs of the various end-users of the environment must be considered, including the patients, the patients’ significant others, and the staff. The aim of this study was to explore the experiences of healthcare professionals participating in group modelling utilizing system dynamics in the pre-design phase of new healthcare environments. We engaged healthcare professionals in a series of workshops using system dynamics to discuss the planning of healthcare environments in the beginning of a construction, and then interviewed them about their experience. An explorative and qualitative design was used to describe participants’ experiences of participating in the group modelling projects. Participants (n=20) were recruited from a larger intervention study using group modeling and system dynamics in planning and designing projects. The interviews were analysed by qualitative content analysis. Two themes were formed, representing the experiences in the group modeling process: ‘Partaking in the G-M created knowledge and empowerment’and ‘Partaking in the G-M was different from what was expected and required time and skills’. The method can support participants in design teams to focus more on their healthcare organization, their care activities and their aims rather than focusing on detailed layout solutions. This clarification is important when decisions about the design are discussed and prepared and will most likely lead to greater readiness for future building process.

Perceptions of the role of the man in family planning, during pregnancy and childbirth : A qualitative study with fifteen Nepali men

Introduction: In Nepal, by tradition, family life and marriage are generally controlled by patriarchal norms, sanctions, values and gender differences. Women in Nepal have limited possibilities to make decisions regarding their sexual and reproductive health, as the husbands and other elders in the family make most of the decisions regarding family planning, pregnancy and childbirth. Aim: To describe the perceptions of Nepali men regarding the role of the man with respect to family planning, pregnancy and childbirth. Methods: A qualitative study was conducted with 15 Nepali men in both urban and rural areas. The material was analyzed through inductive content analysis. Findings: One main category and two generic categories were identified. One generic category contained six subcategories and the other five subcategories. The main category was labeled: “He leads – She follows” and the generic categories were labeled: “Supporting women in family planning, during pregnancy and childbirth” and “Withdrawal from supporting women in family planning, during pregnancy and childbirth”. Conclusion: The role of the Nepali men with respect to family planning, pregnancy and childbirth, was identified as a conflicted approach. This study highlights the importance of understanding the influence of culture and tradition when developing strategies for promoting sexual and reproductive health during family planning, pregnancy and childbirth among families in Nepal.

Exact Probability Distribution versus Entropy

The problem addressed concerns the determination of the average numberof successive attempts of guessing a word of a certain length consisting of letters withgiven probabilities of occurrence. Both first- and second-order approximations to a naturallanguage are considered. The guessing strategy used is guessing words in decreasing orderof probability. When word and alphabet sizes are large, approximations are necessary inorder to estimate the number of guesses. Several kinds of approximations are discusseddemonstrating moderate requirements regarding both memory and central processing unit(CPU) time. When considering realistic sizes of alphabets and words (100), the numberof guesses can be estimated within minutes with reasonable accuracy (a few percent) andmay therefore constitute an alternative to, e.g., various entropy expressions. For manyprobability distributions, the density of the logarithm of probability products is close to anormal distribution. For those cases, it is possible to derive an analytical expression for theaverage number of guesses. The proportion of guesses needed on average compared to thetotal number decreases almost exponentially with the word length. The leading term in anasymptotic expansion can be used to estimate the number of guesses for large word lengths.Comparisons with analytical lower bounds and entropy expressions are also provided.

2083 – A European Declaration of Independence - An Analysis of Discourses from the Extreme

This paper analyses three of the dominating discourses Anders Behring Breivik used in his compendium, the official title of which is 2083 – A European Declaration of Independence, also known as Breivik's Manifesto. It is believed Breivik posted his Manifesto on the Internet shortly before the attacks in Norway in July, 2011. The number 2083 stands for the year when the "Western European Civil War" was expected to be completed, all traitors executed, and all Muslims deported from Europe. This article will discuss dominating discourses in the Manifesto, seen from a background of a European multicultural backlash, in which the political far-right movement is increasing. Furthermore, this article will end with a discussion of education and the importance of analysis of such phenomena within different subjects.

Qualitätssicherung zwischen Diversifizierung der Hochschulen und Vereinheitlichung von Standards. Beiträge zur 2. AQ Austria Jahrestagung 2014

Die Jahrestagung 2014 der AQ Austria widmete sich einerseits dem Spannungsfeld zunehmender Diversifizierung von Hochschulen und standardisierten Qualitätssicherungsverfahren andererseits. Im vorliegenden Jahrestagungsband finden sich neben dem Hauptvortrag des Basler Universitätsrektors Loprieno über die Herausforderungen der Diversifizierung für Qualität sowie der Qualitätskultur an Hochschulen auch internationale Beiträge als Antwort aus der Sicht von Qualitätssicherungsagenturen auf die Diversifizierung. Weitere Artikel zu Themen wie duale Studiengänge, Studierbarkeit, Berufungsverfahren sowie Forschungskultur und Qualitätskultur runden die Diskussion über Qualitätssicherung und Diversifizierung in der vorliegenden Publikation ab. Mit Beiträgen von: Loprieno, Antonio; Hanft, Anke; Pichl, Elmar; Jackson, Stephen; Lund, Øystein; Cox, Jeremy; Fink, Kerstin; Brandstätter, Ursula; Bischof, Horst; Gaberscik, Gerald; Janger, Jürgen; Kastner, Johann; Steiger, Anna; Wilhelm, Elena; Holzinger, Helmut; Esca-Scheuringer, Heidi; Kecht, Maria-Regina; Schulmeister, Rolf; Haas, Johannes.

Skolan är en lättköpt arena - livskunskap i kritisk belysning

During the last decade a school subject with the designation of Life Competence Education ("Livskunskap" in Swedish) has emerged in many Swedish schools. The aim of this article is to describe and analyse the subject Life Competence Education, its historical and ideological roots and current place in the curricula of some selected schools. The article is based on analyses of policy documents, interviews and participant observations from fieldwork in two upper secondary schools and in one course for further training of teachers arranged by a municipality. Work by Foucault, especially on governmentality, is used as an analytic tool, as well as work developed from Foucault by Nicolas Rose and Stephen J. Ball. The analyses show that the subject Life Competence Education is constructed in many varied ways in Swedish schools due to different influences, both from the state, but also from private policy entrepreneurs (Ball, 2006). It is also shown that the SET-programme, which is only one example of programmes used for this type of education, is quite widely used in Life Competence Education in Swedish schools. In light of analyses from Foucault and Rose, I suggest that these programmes can be seen as the "psy", i.e. the "psychological domains" (Rose, 1999), entering into the educational arena and with the help of behaviouristic theories constructing "governable subjects" (Foucault, 1988, 1991). This raises questions regarding what kind of subjects are constructed in Life Competence Education, with what kind of methods, as well as how these methods are construed in the light of the Swedish National Curriculum

Debriefing in simulation conducted in small and large groups : nursing students’ experiences

The debriefing phase in human patient simulation is considered to be crucial for learning. To ensure good learning conditions, the use of small groups is recommended, which poses a major challenge when the student count is high. The use of large groups may provide an alternative for typical lecture-style education and contribute to a more frequently and repeated training which is considered to be important for achieving simulation competency. The purpose of the present study was to describe nursing students’ experiences obtained during the debriefing conducted in small and large groups with the use of a qualitative descriptive approach. The informants had participated in a human patient simulation situation either in large or small groups. Data was collected through the use of five focus-group interviews and analysed by content analysis. The findings showed that independent of group-size the informants experienced the learning strategies to be unfamiliar and intrusive, and in the large groups to such an extent that learning was hampered. Debriefing was perceived as offering excellent opportunities for transferable learning, and activity, predictability and preparedness were deemed essential. Small groups provided the best learning conditions in that safety and security were ensured, but were perceived as providing limited challenges to accommodate professional requirements as a nurse. Simulation competency as a prerequisite for learning was shown not to be developed isolated in conjunction with simulation, but depends on a systematic effort to build a learning community in the programme in general. The faculty needs to support the students to be conscious and accustomed to learning as a heightened experience of learning out of their comfort zone.

Qualitätssicherung an Hochschulen. Anforderung an die Qualitätssicherung und ihre Wirkungen. Beiträge zur 1. AQ Austria Jahrestagung 2013

Im Mittelpunkt dieser Tagungspublikation stehen zwei Kernfragen: Erstens: Welche Interessengruppen stellen welche Anforderungen an die Qualitätssicherung? Diese Frage führt zur Diskussion über den Zweck, den unterschiedliche Interessengruppen mit der Qualitätssicherung verfolgen. Die zweite wichtige Kernfrage betrifft die Wirkungen von Qualitätssicherung. Bewirken sie tatsächlich ein Mehr an Qualität oder dienen sie lediglich der Erfüllung von Berichtspflichten? Und damit eng zusammenhängend: Was sind die intendierten, was die nicht intendierten Effekte von Qualitätssicherung? Die Sicht verschiedener politischer Entscheidungsträgerinnen und -träger, die Sicht der Studierenden und die Sicht der Qualitätssicherungsagentur über die Anforderungen und Wirkungen von Qualitätssicherung werden dargestellt. Ebenso beleuchten Beiträge von Repräsentantinnen und Repräsentanten der Hochschulsektoren die beiden Kernfragen. Die Beiträge zeigen, wo gemeinsame und wo unterschiedliche Interessen bestehen. Mit Beiträgen von: Burckhart, Holger; Hanft, Anke; Hopbach, Achim; Töchterle, Karlheinz; Kazoka, Asnate; Badelt, Christoph; Eckl, Martha; Wulz, Janine; Mann, Susanne; Feucht, Gudrun; Brandstätter, Wilhelm; Moser, Josef-Anton; Treml, Beate; Kainz, Harald; Gaberscik, Gerald; Fink, Kerstin; Wöber, Karl.

Att kvalificera ett samtalsuppdrag : Om ett utvecklingsarbete i speciallärarprogrammet

I denna rapport redovisas ett utvecklingsarbete som genomfördes vid speciallärarprogrammet vid Karlstads universitet läsåret 2010/2011. Enligt examensordningen är en av speciallärarens arbetsuppgifter att vara en kvalificerad samtalspartner. Vad som menas med kvalificerad samtalspartner är upp till varje lärosäte/ varje speciallärare att själv fylla med innehåll. Syftet med rapporten är att beskriva ett utvecklingsarbete och de erfarenheter som gjordes och därmed sätta ord på delar av speciallärarens yrkeskunnande som kvalificerade samtalspartners. Utvecklingsarbetets övergripande syfte var att pröva dialogseminarieformen för att fördjupa speciallärarnas yrkeskunnande i deras uppdrag som kvalificerade samtalspartners. Eller uttryckt med andra ord kvalificera ett samtalsuppdrag. I arbetet med dialogseminarier lyfts andra värden än de i utbildningssammanhang så vanliga; effektivitet, snabbhet, mätbarhet till förmån för långsamhet, eftertänksamhet och kanske ett gott omdöme. Efter en termins arbete med dialogseminarier kan vi nu dra slutsatsen att deltagande i dialogseminerier tycks ha bidragit till att: öka studenternas reflektionsförmåga öka deras förmåga att lyssna både inåt och utåt knyta förbindelser mellan det personliga och det professionella utveckla deras yrkesspråk och kanske deras omdömesförmåga.

Äldre i Värmland : Om hälsa, levnadsvanor och livssituation 2006

Landstinget har i samarbete med Karlstads universitet gjort flera befolkningsundersökningar i Värmland och publicerat rapporter om både den vuxna befolkningens och barns hälsa, senast med rapporten Värmlänningarnas Liv och Hälsa 2004. Någon befolkningsstudie av de äldres hälsa och livsvillkor har dock inte gjorts tidigare. Efter tre års förarbeten och samråd mellan landstinget, Värmlands kommuner och flera institutioner vid Karlstads universitet genomfördes den föreliggande studien av de äldres hälsa under senhösten 2006, i form av en omfattande postenkät. Urvalet utgjordes av 2500 slumpmässigt uttagna kvinnor och män som var 80 år eller äldre. Svarsfrekvensen var 60 procent, vilket får betraktas som mycket bra med tanke på att cirka 15 procent i denna åldersgrupp lever i särskilda boenden. Studien avspeglar således hälsan och livsvillkoren för de äldre. Överlag visar det sig att de äldre mår bra och har stor kapacitet att fungera som aktiva samhällsmedborgare. Samtidigt är det många som har kroniska besvär, med värk, syn- och hörselnedsättning, inkontinensbesvär etc. Det föreligger också en klar social gradient, där särskilt äldre kvinnor med arbetarbakgrund har både mer sjukdom och större ekonomiska problem än de övriga.

Johannes Angermüller / Silke van Dyk (Hrsg.): Diskursanalyse meets Gouvernementalitätsforschung. Perspektiven auf das Verhältnis von Subjekt, Sprache, Macht und Wissen. Frankfurt am Main: Campus 2010 [Rezension]

Rezension von: Johannes Angermüller / Silke van Dyk (Hrsg.): Diskursanalyse meets Gouvernementalitätsforschung. Perspektiven auf das Verhältnis von Subjekt, Sprache, Macht und Wissen. Frankfurt am Main: Campus 2010 (341 S.; ISBN Frankfurt am Main)

NK Cells of Kidney Transplant Recipients Display an Activated Phenotype that Is Influenced by Immunosuppression and Pathological Staging

To explore phenotype and function of NK cells in kidney transplant recipients, we investigated the peripheral NK cell repertoire, capacity to respond to various stimuli and impact of immunosuppressive drugs on NK cell activity in kidney transplant recipients. CD56(dim) NK cells of kidney transplanted patients displayed an activated phenotype characterized by significantly decreased surface expression of CD16 (p=0.0003), CD226 (p<0.0001), CD161 (p=0.0139) and simultaneously increased expression of activation markers like HLA-DR (p=0.0011) and CD25 (p=0.0015). Upon in vitro stimulation via Ca++-dependent signals, down-modulation of CD16 was associated with induction of interferon (IFN)-gamma expression. CD16 modulation and secretion of NFAT-dependent cytokines such as IFN-gamma, TNF-alpha, IL-10 and IL-31 were significantly suppressed by treatment of isolated NK cells with calcineurin inhibitors but not with mTOR inhibitors. In kidney transplant recipients, IFN-gamma production was retained in response to HLA class I-negative target cells and to non-specific stimuli, respectively. However, secretion of other cytokines like IL-13, IL-17, IL-22 and IL-31 was significantly reduced compared to healthy donors. In contrast to suppression of cytokine expression at the transcriptional level, cytotoxin release, i.e. perforin, granzyme A/B, was not affected by immunosuppression in vitro and in vivo in patients as well as in healthy donors. Thus, immunosuppressive treatment affects NK cell function at the level of NFAT-dependent gene expression whereby calcineurin inhibitors primarily impair cytokine secretion while mTOR inhibitors have only marginal effects. Taken together, NK cells may serve as indicators for immunosuppression and may facilitate a personalized adjustment of immunosuppressive medication in kidney transplant recipients.

Artificial Skin - Culturing of Different Skin Cell Lines for Generating an Artificial Skin Substitute on Cross-Weaved Spider Silk Fibres

Background: In the field of Plastic Reconstructive Surgery the development of new innovative matrices for skin repair is in urgent need. The ideal biomaterial should promote attachment, proliferation and growth of cells. Additionally, it should degrade in an appropriate time period without releasing harmful substances, but not exert a pathological immune response. Spider dragline silk from Nephila spp meets these demands to a large extent. Methodology/Principal Findings: Native spider dragline silk, harvested directly out of Nephila spp spiders, was woven on steel frames. Constructs were sterilized and seeded with fibroblasts. After two weeks of cultivating single fibroblasts, keratinocytes were added to generate a bilayered skin model, consisting of dermis and epidermis equivalents. For the next three weeks, constructs in co-culture were lifted on an originally designed setup for air/liquid interface cultivation. After the culturing period, constructs were embedded in paraffin with an especially developed program for spidersilk to avoid supercontraction. Paraffin cross-sections were stained in Haematoxylin & Eosin (H&E) for microscopic analyses. Conclusion/Significance: Native spider dragline silk woven on steel frames provides a suitable matrix for 3 dimensional skin cell culturing. Both fibroblasts and keratinocytes cell lines adhere to the spider silk fibres and proliferate. Guided by the spider silk fibres, they sprout into the meshes and reach confluence in at most one week. A well-balanced, bilayered cocultivation in two continuously separated strata can be achieved by serum reduction, changing the medium conditions and the cultivation period at the air/liquid interphase. Therefore spider silk appears to be a promising biomaterial for the enhancement of skin regeneration.