Influência das substâncias húmicas aquáticas na genotoxicidade dos metais em tilápias do Nilo (Oreochromis niloticus)

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Situação Espacial de Franquias na América do Sul: morfologia e centralidade urbanas em cidades médias da Argentina, Brasil e Chile

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Enzimas de biotransformação em tilápia (Oreochromis niloticus) exposta ao hormônio natural 17b-estradiol

Among the sexual hormones the estrogens are receiving major attention due to their biological activity. Such biological response is atributed to the best conformation recognized by their receptors, resulting in maximum responses. The estrogens are also considered responsible for most of disruptor´s effects caused by their presence in aquatic ecosystems. The 17β-estradiol hormone is produced by vertebrates during the reproductive phase of their lives and its presence has been detected in superficial waters. The objective of this study was to evaluate the cause-effect of tilapia exposition to the hormone 17β-estradiol through the analysis of biotransformation enzymes in liver and gills, complemented with the quantification of 17β-estradiol and estrone in water samples collected from fish ponds integrated to swine production. The present study was conducted under laboratory conditions, in a randomized experimental design with three levels of 17β-estradiol (E2) (0, 5, 15 µg L-1), with three replicates. After 7 days of exposure time, liver and gills were extracted to analyze three isoforms of cytochrome P450: EROD, BROD, PROD and the activity of Glutathione S-Transferase (GST). The results showed that the EROD activity (CYP1A), normally induced by the metabolism of aromatic compounds, did not present statistical differences among the treatments exposed to E2, what means that the hormone did not induce isoform 1A in fish under these particular experimental conditions. PROD activity was significantly altered in both concentrations, by means of 5 and 15 µg L-1, when compared to control. This result can indicate an important role of PROD on the metabolism of E2 present in water. Regarding to the BROD activity, it could be observed differences statistically significant between control and both groups of treatments. Two or more CYP isoforms can contribute to the metabolism of the same compound, what makes BROD a candidate as a next bioindicator of the exposure to E2 in aquatic ecosystems. Analysis of variance could confirm the effect of E2 statistically significant on the GST activity in liver tissues with >90% of significance (Prob>F = 0.0753). Furthermore, it was possible to observe that the values of GSTs activities in liver and gills in both, control and treatments, follow a tendency, that means, enzymatic activity in gills increase as the increasing of the activity in the liver tissues. In this study, the 17β–estradiol was found in measurable concentrations in three sampled points, and these values were similar to the findings of other authors at different locations in Brazil. In addition, those values are much higher than the minimum concentration that presented observable effects (10 ng L-1).

Análise microestrutural de tubos API N80 soldados pelo processo HF/ERW para prospecção de petróleo e gás

On the grounds of the great advances achieved over recent years, the process HF/ERW (High-Frequency/Electric Resistance Welding)welded pipe have played an active role in the oil and gas industry for deep water applications, at high and extremely low temperatures, under high pressure and in highly corrosive environments, gradually replacing manufactured pipes by other processes. However, studies have shown that defects in the welded joints are a the leading causes of pipelines failures, which has required the determination of toughness values in this region, in compliance with the strict recommendations of the codes and standards with manufacturers and construction companies, on the oil and gas sector. As part of the validation process required toughness values, this research project focuses on a microstructural analysis in HF / ERW tubes microalloyed, steel grade API 5CT N80, designed to explore oil and gas in deep waters, the subject of strategic relevance to the country because of the recent discoveries in the Santos mega fields: Tupi and Libra (pre-salt). In this scientific work will be presented and discussed the results of mechanical tensile and Charpy, a few CTOD tests curves (showing the trend of toughness values to be obtained), and the microstructures of the base material obtained by optical microscopy, with special emphasis on the formation of non-metallic inclusions in the welded joint

Usinabilidade e integridade superficial de implantes dentários

Pós-graduação em Engenharia Mecânica - FEIS

Incorporação da apatita na superfície da liga Ti30ta empregando tratamento alcalino associado à eletrofiação de fibras de PCL

Pós-graduação em Engenharia Mecânica - FEG

Análise morfotectônica do Planalto Ocidental Paulista, ao sul do Rio Tietê: indicadores de deformações neotectônicas na fisiografia da paisagem

Pós-graduação em Geologia Regional - IGCE

Desenvolvimento de um simulador virtual de vazamento para testar correlacionadores acústicos comerciais

Pós-graduação em Engenharia Mecânica - FEIS

Estudos estruturais com a importina-α do fungo Neurospora crassa e sequências de localização nuclear

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Procedimentos de pesquisa em Geografia do Comércio e do Consumo: delimitação, intensidade e especialização de áreas centrais. Análises a partir de Marília/SP, São Carlos/SP e São José do Rio Preto/SP

This academic report presents results of the research developed between 2012 and 2015, and it had as main goal the development of new mapping possibilities of the central areas of the cities of Marília/SP, São Carlos/SP and São José do Rio Preto/SP. We developed this research using mostly the database from Cadastro Nacional de Endereços Para Fins Estatísticos (CNEFE), and after processing the information, it was added the typology established in the Cadastro Nacional de Atividades Econômicas (CNAE). This database, after the final treatment process, provided us information that made possible the production of thematic maps which are used to study central areas, allowing the analysis of spatial logics of companies, the identification of concentration and dispersion of economic activities, arrangement of specialized axis, expansion of the central area, reorganization of the city, among other process and phenomena

Aços avançados de alta resistência: avaliação da microestrutura e propriedades dos aços DP 600 E DP 780

This work aims to study the Dual-Phase 600 and 780 steels, which are part of technology development project materials for the automotive industry. It is worth underscoring the antagonistic properties as the Dual-Phase steel assemble, high mechanical strength and elongation due its microstructure, ferrite and martensite. These properties are obtained by a intercritical heat treatment which facilitates the formation of a hardness metastable microstructure shaped plates of low carbon steels. The applicability of Dual Phase steel in the structure of vehicles is huge and its production is already on a commercial scale, so the study and development of this material implies lower cost in automobile manufacturing processes. The dual phase steels DP600 and DP780 underwent tensile, hardness and metallographic analysis to evaluate and comparing its properties. The results indicate that the DP780 steel has higher strength and hardness than the DP600 steel and its microstructure consists of martensite higher fraction which accounts for the higher resistance and hardness. However, the DP600 has higher conformability to DP780 steel

Análise da reversão do fundo de latas de alumínio para bebidas - Buckle

This work approaches the main methods of plastic deformation of metals, with a focus on the deep drawing process. The mechanical properties were evaluated with the tension tests. It is presented the aluminum alloys designation, followed by applying heat treatments and the designation of tempers. The manufacture of aluminum beverage cans is described step by step, in general terms. The main objective is to analyze how different cans background geometries have great influence on the dome reversal. To be able to achieve the goal it was necessary to use cans of different manufacturers, which were used in buckle tests to obtain the reversal pressures, tensile tests and geometric analysis. Finally empirical equations were obtained correlating these variables, and it was observed that the conformation of reforming change significantly it's behavior

Considerações e avaliações das solicitações em estruturas de edificações de paredes de concreto pré-moldado utilizando o modelo de pórtico tridimensional: estudo de caso

The present study is in reference to precast concrete (panels) walls as the main structural system. The diversification of the structural systems is a reality due to specific characteristics', as a result there is a lack of study and analysis. Some systems are already established in their applications, for instance: conventional reinforced concrete, structural masonry, metal structures, and wood structure. Apart from this precast concrete elements has had a growth in building sites in Brazil, therefore professionals should be more aware. Affordable house funding initiatives to address the housing shortage has been recurrent throughout the country, additionally precast concrete walls has been an alternative that meets the three basic concepts of engineering, which are: the technique, economy, and security. The objective of this study is to gather concepts from the literature and TOMO (2012) about precast concrete walls and make a didactic synthesis of how they are viewed. The modeling structure method of the system was performed following the concept of assigning bars, using the computer program of calculations SAP2000. Initially will be presented a theoretical part, furthermore a case study to illustrate the sizing of the walls using EXCEL tables programmed with calculation routine. The results will be presented in calculated efforts by the program for further analysis. Finally, will be highlighted important items of modeling and interpretation of the results

Estudo das alterações das propriedades mecânicas em aço A-516 grau 70 soldado e submetido a tratamento térmico de alívio de tensões

Pressure vessels are equipments that require a great care because of their high cost and human life risk in case of fail, and its fabrication methods are different for each manufacturer. Normally, pressure vessels and its parts are fabricated by welding, which may change local properties of metals. The head of a pressure vessel is a very important structural component and it is fabricated by welding and mechanical conformation. Because its excellent mechanical properties, de steel A-516 Grade 70 is often used in manufacturing of large pressure vessels that are subjected to high pressure and temperature, but was verified that its mechanical resistance is decreased when submitted to a tension relief heat treatment. By experience it was defined that before mechanical conformation of the head of a large pressure vessel, the steel should be submitted to a stress relief heat treatment in order to facilitate the mechanical conformation, but there is no quantitative analysis to prove this method and study its possible risks. In the present work the steel A-516 Grade 70 demonstrated a decrease of its mechanical resistance when submitted to a stress relief heat treatment, but keeping above the minimum limit defined in the literature. By other side its ductility was substantially increased, being possible to deduce that the stress relief heat treatment before mechanical conformation is a viable e recommended technique, but with reservations. With the data acquired during the fabrication e preparation of the specimen and the result of the tests, it was possible to elaborate a welding procedure that provides the same results obtained in this present work

Desenvolvimento de biossensores capacitivos constituídos de monocamadas peptídicas nanometricamente estruturadas

Pós-graduação em Biotecnologia - IQ