Tongemälde : für großes Orchester ; nämlich: 2 Violinen, Bratsche, Violoncelle, und Contrabaß, 2 Flöten, 2 Oboen, 2 Clarinetten, 2 Fagotte, 4 Hörner, 3 Posaunen, Trompetten und Pauken

von Aloys Schmitt

Na 1 Nachlass Max Horkheimer, 640 - "Simmel and Freudian Philosophy", "Authoritarianism and the Family Today" und "The Chances of Democracy in Germany" (p. IX 18.1-3-IX 19a)

"Simmel and Freudian Philosophy" (GS 5, S. 396-405); 1. Nachruf, verlesen beim Memorial Meeting for Ernst Simmel; datiert: 13.12.1947; veröffentlicht in: International Journal of Psychoanalysis, 29. Jahrgang, 1948, S. 110-113; 2. Abschrift aus Werken und Briefen Siegmund Freuds; Typoskript, 9 Blatt; 3. Freeman, Burriel: 1 Brief mit Unterschirft an Max Horkheimer, Chicago, 10.06.1949; 1 Brief von Max Horkheimer, Los Angeles, 15.06.1949, 2 Blatt; "Authoritarianism and the Family Today" (GS 5, S. 377-395); 1. Aufsatz, datiert 1947, veröffentlicht in: Ruth Nanda Anshen (editor), "The Family: Its Function and Distiny", New York 1949. a) Typsokript, 20 Blatt b) Typoskript mit handschriftlichen Korrekturen, 20 Blatt c) Typoskript mit eigenhändigen Korrekturen, 20 Blatt d)-f) deutsche Fassung mit dem Titel "Autorität und Familie", übersetzt vom Institut für Sozialforschung, 1960; veröffentlicht in : "Erkenntnis und Verantwortung. Festschrift für Theodor Litt", Düsseldorft, 1960 d) Typoskript, 20 Blatt e) Typoskript, 20 Blatt f) Korrekturfahnen aus der Litt- Festschrift, mit dem Titel "Autorität und Familie in der Gegenwart"; 6 Blatt; 2. Schönbach, Peter: 1 Brief mit Unterschrift an Max Horkheier, ohne Ort, 23.06.1960; 1 Blatt; 3. Schönbach, Peter: 1 Brief mit Unterschrift an Friedrich Pollock, ohne Ort, 22.06.1960; 1 Blatt; "The Chances of Democracy in Germany" (GS 12, S. 184-194); 1947 [?] a) Typoskript, 10 Blatt b) Typoskript mit eigenhändigen Korrekturen, 11 Blatt c) Typoskript mit eigenhändigen Korrekturen ,11 Blatt;

Rede, gehalten bei dem Trauerg[o]ttesdienst zum Gedächtniss des seligen Freiherrn Wilhelm Carl von Rothschild in der Synagoge zu Lübeck, am Sonntag, den 14. Schwat 5661 (3. Febr. 1901), Nachm. 4 Uhr

von S. Carlebach

p21 activated kinase 5 links multiple GTPase signaling pathways at mitochondria

The p21-activated kinase 5 (PAK5) is a serine/threonine protein kinase associated with the group 2 subfamily of PAKs. Although our understanding about PAK5 is very limited, it is receiving increasing interest due to its tissue specific expression pattern and important signaling properties. PAK5 is highly expressed in brain. Its overexpression induces neurite outgrowth in neuroblastoma cells and promotes survival in fibroblasts. ^ The serine/threonine protein kinase Raf-1 is an essential mediator of Ras-dependent signaling that controls the ERK/MAPK pathway. In contrast to PAK5, Raf-1 has been the subject of intensive investigation. However due to the complexity of its activation mechanism, the biological inputs controlling Raf-1 activation are not fully understood. ^ PAKs 1-3 are the known kinases responsible for phosphorylation of Raf-1 on serine 338, which is a crucial phosphorylation site for Raf-1 activation. However, dominant negative versions of these kinases do not block EGF-induced Raf-1 activation, indicating that other kinases may regulate the phosphorylation of Raf-1 on serine 338. ^ This thesis work was initiated to test whether the group 2 PAKs 4, 5 and 6 are responsible for EGF-induced Raf-1 activation. We found that PAK5, and to a lesser extent PAK4, can activate Raf-1 in cells. Our studies thereafter focused on PAK5. With the progress of our study we found that PAK5 does not significantly stimulate serine 338 phosphorylation of Triton X-100 soluble Raf-1. PAK5, however, constitutively and specifically associates with Raf-1 and targets it to a Triton X-100 insoluble, mitochondrial compartment, where PAK5 phosphorylates serine 338 of Raf-1. We further demonstrated that endogenous PAK5 and Raf-1 colocalize in Hela cells at the mitochondrial outer membrane. In addition, we found that the mitochondria-targeting of PAK5 is determined by its C-terminal kinase domain plus the upstream proximal region, and facilitated by the N-terminal p21 binding domain. We also demonstrated that Rho GTPases Cdc42 and RhoD associate with and regulate the subcellular localization of PAK5. Taken together, this work suggests that the mitochondria-targeting of PAK5 may link Ras and Rho GTPase-mediated signaling pathways, and sheds light on aspects of PAK5 signaling that may be important for regulating neuronal homeostasis. ^

Geochemistry on smectites in sediment cores CRP-1 and CRP-2 from the Ross Sea, Antarctica

TEM (transmission electron microscopy) observations and microanalyses on smectite microparticles in the sediments of the CRP-2A core were carried out to determine their origin (authigenic or detrital) and the source rocks. Smectites are dioctahedral and are Fe-rich members of the nontronite-beidellite series. They generally display both flaky and hairy shapes, but no large compositional difference between the two forms was observed. Flaky smectites are detrital while hairy smectites probably formed in situ through the reorganisation of previous flaky particles. The source rocks for smectites are probably represented by the McMurdo Volcanic Group to the south, but also by the Ferrar Dolerites and Kirkpatrick Basalts in the Transantarctic Mountains. CRP-2A smectites are Fe and Mg richer than those of the coeval or not coeval levels of the CIROS-I, DSDP 270 and 274 cores. The average compositions of smectite in CRP-1 and CRP-2A cores show a downcore trend toward more alluminiferous terms, which might reflect the increase of the chemical weathering processes on the continent.