Macrophage migration inhibitory factor in the nucleus of solitary tract decreases blood pressure in SHRs

Aims The macrophage migration inhibitory factor (MIF) is an intracellular inhibitor of the central nervous system actions of angiotensin II on blood pressure. Considering that angiotensin II actions at the nucleus of the solitary tract are important for the maintenance of hypertension in spontaneously hypertensive rats (SHRs), we tested if increased MIF expression in the nucleus of the solitary tract of SHR alters the baseline high blood pressure in these rats.Methods and resultsEight-week-old SHRs or normotensive rats were microinjected with the vector AAV2-CBA-MIF into the nucleus of the solitary tract, resulting in MIF expression predominantly in neurons. Rats also underwent recordings of the mean arterial blood pressure (MAP) and heart rate (via telemetry devices implanted in the abdominal aorta), cardiac- and baroreflex function. Injections of AAV2-CBA-MIF into the nucleus of the solitary tract of SHRs produced significant decreases in the MAP, ranging from 10 to 20 mmHg, compared with age-matched SHRs that had received identical microinjections of the control vector AAV2-CBA-eGFP. This lowered MAP in SHRs was maintained through the end of the experiment at 31 days, and was associated with an improvement in baroreflex function to values observed in normotensive rats. In contrast to SHRs, similar increased MIF expression in the nucleus of the solitary tract of normotensive rats produced no changes in baseline MAP and baroreflex function.ConclusionThese results indicate that an increased expression of MIF within the nucleus of the solitary tract neurons of SHRs lowers blood pressure and restores baroreflex function. © 2012 Published on behalf of the European Society of Cardiology. All rights reserved.

Intraregional migration of skilled manpower

Includes bibliography

Globalization and international migration: the Latin American experience

Includes bibliography

International migration and development: the socioeconomic impact of remittances in Colombia

Includes bibliography

Spatial distribution, internal migration and development in Latin America and the Caribbean

Includes bibliography

International migration, human rights and development in Latin America and the Caribbean: summary and conclusions

Includes bibliography

International migration, human rights and development in Latin America and the Caribbean: summary and conclusions

Includes bibliography

Macrophage migration inhibitory factor and oral cancer

Background: Macrophage migration inhibitory factor (MIF) is a pleiotropic cytokine with pro-inflammatory functions and involved in tumorigenesis. The aim of this study was to evaluate the expression and localization of the macrophage MIF in oral squamous carcinoma (OSC). In addition, the relationship between MIF expression and clinicopathological parameters such as survival data, tobacco use, alcohol habits, TNM stage, tumor graduation, and peritumoral inflammatory infiltrate were evaluated. Methods: Using immunohistochemistry, expression and localization of MIF was detected in 44 specimens of OSC. The absolute number and relative proportions of MIF-positive cells detected were also determined separately for tumor parenchyma vs. stroma. All counts were determined from 10 consecutive high-power fields using an integration graticule. Moreover, some parameters were analyzed separately for lip and intra-oral cancers. Results: Migration inhibitory factor-positive cells were observed in both the tumor parenchyma and in inflammatory cells of all specimens. In contrast, MIF expression was not detected in tumoral nests associated with poorly differentiated tumors. In specimens of lip cancer, a greater number of MIF-positive stromal immune cells were detected than in intra-oral cancer specimens (Mann-Whitney test, P = 0.049). Conclusions: Oral squamous carcinoma cells consistently express MIF independent of their location. Lip tumors presented more MIF-positive peritumoral inflammatory cells, similar to control, suggesting that immunological differences in leukocyte activation exist between in lip and intra-oral cancers. © 2012 John Wiley & Sons A/S.

Resolution 615(XXXI): International migration

Includes bibliography

Activities report of the working group on migration and trends in remitances

Includes bibliography

Migración y urbanización: las barriadas limeñas: un caso de integración a la vida urbana = Migration and urbanization: The barriadas" of Lima: an example of integration into urban life"

Los documentos del Seminario fueron publicados por UNESCO en 1961 con el título: La urbanización en América Latina/Urbanization in Latin America

Problemas económico-sociales sobre migración y urbanización en la ciudad de Esmeraldas, República del Ecuador = Socio-economic problems of migration and urbanization in the town of Esmeraldas, Ecuador

Los documentos del Seminario fueron publicados por UNESCO en 1961 con el título: La urbanización en América Latina/Urbanization in Latin America

Working Group on the Methodology for the Study of International Migration: introductory paper for the meeting

Se detallan los antecedentes del proceso de constitucion del grupo de trabajo sobre la metodologia para el estudio de la migracion internacional y se plantean algunas bases para la discusion en la primera reunion de dicho grupo a realizarse en Helsinki en septiembre de 1978. Se aportan datos sobre la labor desarrollada por el Centro Latinoamericano de Demografia (CELADE) en el estudio de las migraciones internacionales en los paises latinoamericanos. Se inserta la agenda de la reunion de Helsinki.