Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules.

The lpr gene has recently been shown to encode a functional mutation in the Fas receptor, a molecule involved in transducing apoptotic signals. Mice homozygous for the lpr gene develop an autoimmune syndrome accompanied by massive accumulation of double-negative (DN) CD4-8-B220+ T cell receptor-alpha/beta+ cells. In order to investigate the origin of these DN T cells, we derived lpr/lpr mice lacking major histocompatibility complex (MHC) class I molecules by intercrossing them with beta 2-microglobulin (beta 2m)-deficient mice. Interestingly, these lpr beta 2m-/- mice develop 13-fold fewer DNT cells in lymph nodes as compared to lpr/lpr wild-type (lprWT) mice. Analysis of anti-DNA antibodies and rheumatoid factor in serum demonstrates that lpr beta 2m-/- mice produce comparable levels of autoantibodies to lprWT mice. Collectively our data indicate that MHC class I molecules control the development of DN T cells but not autoantibody production in lpr/lpr mice and support the hypothesis that the majority of DN T cells may be derived from cells of the CD8 lineage.

Statsminister Ahti Karjalainen 30.8.1971

Kirje

Kirjailija Pentti Saarikoski 8/12 1971

Kirje 8.12.1971

Motor Vehicle Crash Fatalities for Week Ending, May 8, 2009, 2009

Motor Vehicle Crash Fatalities

EPI Update, May 8, 2009

Weekly newsletter for Center For Acute Disease Epidemiology of Iowa Department of Public Health.

Göttingen 10/8 1929

Kirje 10.8.1929

Operación Eureka XXIV. 5 - 8 setiembre 1972

Intenta determinar la distribución y concentración de la anchoveta, en la operación realizada a lo largo de la costa durante días (5 - 8 de setiembre de 1972)m cib 36 bolicheras y 72 investigadores.

Helsinki 17/8 1941

Kirje 17.8.1941

Cuarto crucero del barco de exploración científica Profesor Mesiatsev (VNIRO). 12 de diciembre 1972 - 8 enero 1973. Informe sobre los trabajos científico-pesqueros en las aguas adyacentes a la costa del Perú

Informa sobre los resultados de los trabajos conjuntos del VNIRO (URSS) e IMARPE (Perú) como parte de un convenio de cooperación técnica Peruano-Soviético, que tuvo por finalidad estudiar los recursos pesqueros del litoral peruano.

Pääministeri Reino R. lehto 5.8.1964

Kirje