868 resultados para Wish to hasten death
Resumo:
Given the expectations that western governments had in the reforms being implemented by the Unidad Popular, the September 1973 coup d’état in Chile caused a great international outcry. The violence and repression that accompanied the military coup produced a worldwide repudiation of the military junta. Sweden stood out most consistently among the countries that declared their opposition to Chile during the period of the dictatorship by continuously denouncing the violations to human rights. In this context, Sweden’s Ambassador to Chile, Harald Edelstam, played a very important role in saving the lives of hundreds of Chilean citizens and foreign nationals who sought refuge from the regime’s bloody repression. Making use of the privileges he enjoyed as a diplomat, Edelstam confronted the military authorities to release people wrongfully sentenced to the death penalty. As a result, he was declared persona non grata and forced to leave Chile. This was the beginning of a long and controversial diplomatic relationship that lasted until the return of democracy in Chile in 1990. This article is a first attempt at understanding how human rights violations affected bilateral relations between Chile and Sweden with respect to the diplomatic efforts of Ambassador Harald Edelstam.
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Abstract At Ångström Laboratory, one of the largest campuses at Uppsala University, the Library and the Student Services Office merged in November 2012. This merger is a pilot project to improve service for students and faculty. Ångström Laboratory has around 900 staff and almost 10,000 students, of whom most also spend time at other campuses. In this paper we describe the background and the implementation of the pilot project. One of the main reasons for moving together was the wish to gather together all kinds of student services, including the distribution of written examinations in one place. The central location and open environment of the Library made it a good choice. The heart of the Library and Student Services is an open office consisting of two service desks located in the library area. There are silent study areas; computers for searching and printing, an area for relaxing with newspapers and journals, meeting rooms and offices for the staff. The result is a lively place with a cosy atmosphere. As the Library and the Student Services still belong to different parts of the University we are now starting to find out how best to collaborate. To understand more we log all the questions we get and the services we deliver. We also have meetings together and use the same lunch room to get to know each other and our different functions. We will define which matters can be solved in common, and how we can back each other up when necessary.
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I am honored to respond to Paul Guyer’s elaboration on the role of examples of perfectionism in Cavell’s and Kant’s philosophies. Guyer’s appeal to Kant’s notion of freedom opens the way for suggestive readings of Cavell’s work on moral perfectionism but also, as I will show, for controversy. There are salient aspects of both Kant’s and Cavell’s philosophy that are crucial to understanding perfectionism and, let me call it, perfectionist education, that I wish to emphasize in response to Guyer. In responding to Guyer’s text, I shall do three things. First, I shall explain why I think it is misleading to speak of Cavell’s view that moral perfectionism is involved in a struggle to make oneself intelligible to oneself and others in terms of necessary and sufficient conditions for moral perfection. Rather, I will suggest that the constant work on oneself that is at the core of Cavell’s moral perfectionism is a constant work for intelligibility. Second, I shall recall a feature of Cavell’s perfectionism that Guyer does not explicitly speak of: the idea that perfectionism is a theme, “outlook or dimension of thought embodied and developed in a set of texts.” Or, as Cavell goes on to say, “there is a place in mind where good books are in conversation. … [W]hat they often talk about … is how they can be, or sound, so much better than the people that compose them.” This involves what I would call a perfectionist conception of the history of philosophy and the kinds of texts we take to belong to such history. Third, I shall sketch out how the struggle for intelligibility and a perfectionist view of engagement with texts and philosophy can lead to a view of philosophy as a form of education in itself. In concluding these three “criticisms,” I reach a position that I think is quite close to Guyer’s, but with a slightly shifted emphasis on what it means to read Kant and Cavell from a perfectionist point of view.
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Bakgrund: Barnmorskans arbetsfält omfattar idag sexuell-, reproduktiv- och perinatal hälsa och det centrala i yrkesutövningen är att främja hälsa. Barnmorskan ska ha kunskaper om, kunna ge information och undervisa om sexualitet och samlevnad utifrån ett genus- och livscykelperspektiv. Uppdraget på ungdomsmottagning är att arbeta med sexualitet och hälsa samt att förebygga oönskade graviditeter och STI. Syfte: Syftet var att beskriva barnmorskors erfarenheter av preventivmedelsrådgivning på ungdomsmottagning. Metod: Individuella intervjuer genomfordes med nio barnmorskor på ungdomsmottagningar. Vid intervjutillfället användes en frågeguide och semistrukturerade frågor ställdes. Som analysmetod användes kvalitativ innehållsanalys. Resultat: Fyra kategorier och 15 subkategorier identifierades. Kategorierna var enligt följande: Erfarenheten och kunskapens betydelse, Det kliniska arbetssättet, Modererande faktorer och Utmaningar. Slutsats: Barnmorskor uppgav god kunskap och goda erfarenheter av ungdomar och preventivmedelsrådgivning på ungdomsmottagning men menade att det är ett dynamiskt arbete som bidrar till ständig utveckling. Vid möten med preventivmedelssökande ungdomar på ungdomsmottagning fanns önskan att mötet skulle ske på individnivå. Erfarenheter av modererande faktorer för barnmorskan, utmaningar för preventivmedelsrådgivningen och följsamheten fanns vilket innebar att preventivmedelsrådgivning för ungdomar på ungdomsmottagning är komplext. Klinisk tillämpbarhet: Studiens resultat skulle kunna innebära ökad förståelse för arbetet på ungdomsmottagning och skapa underlag för att möta utmaningarna som barnmorskorna möter i det dagliga arbetet.
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Introduction: Studies have shown that having a preterm infant may cause stress and powerlessness for parents. It is important to support parents around the feeding situation, and that the Neonatal Intensive Care Unit (NICU) has appropriate space and place to help the family to bond to each other. For the healthcare professionals it is important to promote skin-to-skin contact and breastfeeding; particularly for preterm infants. There are many studies on parent’s experiences of NICUs and a few studies on parent’s experiences of feeding their infant in the NICU. Objective: The objective of this study was to explore parents experiences of feeding their infant in the NICU. Design: The study was conducted using an ethnographic design. Results: A global theme of ‘The journey in feeding’ was developed from four organising themes: ‘Ways of infant feeding’; ‘Environmental influences’; ‘Relationships’ and ‘Emotional factors’. These themes illustrate the challenges mothers reported with different methods of feeding. The environment had a big impact on parent’s experiences of infant feeding. Some mothers felt that breastfeeding seemed unnatural because their infant was so tiny but breastfeeding and skin-to-skin contact helped them to bond to their infant. The mothers thought it was difficult to keep up with the milk production by only pumping. Routines were not inviting parents to find their own rhythm. They also felt stressed about the weighing. Healthcare professionals had positive and negative influences on the parents. Conclusions: This study demonstrates that while all parents expressed the wish to breastfeed, their ‘journey in feeding’ was highly influenced by method of feeding, environmental, relational and emotional factors. The general focus upon routines and assessing milk intake generated anxiety and reduced relationality. Midwives and neonatal nurses need to ensure that they emphasise and support the relational aspects of parenting and avoid over-emphasising milk intake and associated progress of the infant
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The practitioners of bioinformatics require increasing sophistication from their software tools to take into account the particular characteristics that make their domain complex. For example, there is a great variation of experience of researchers, from novices who would like guidance from experts in the best resources to use to experts that wish to take greater management control of the tools used in their experiments. Also, the range of available, and conflicting, data formats is growing and there is a desire to automate the many trivial manual stages of in-silico experiments. Agent-oriented software development is one approach to tackling the design of complex applications. In this paper, we argue that, in fact, agent-oriented development is a particularly well-suited approach to developing bioinformatics tools that take into account the wider domain characteristics. To illustrate this, we design a data curation tool, which manages the format of experimental data, extend it to better account for the extra requirements placed by the domain characteristics, and show how the characteristics lead to a system well suited to an agent-oriented view.
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The practitioners of bioinformatics require increasing sophistication from their software tools to take into account the particular characteristics that make their domain complex. For example, there is a great variation of experience of researchers, from novices who would like guidance from experts in the best resources to use to experts that wish to take greater management control of the tools used in their experiments. Also, the range of available, and conflicting, data formats is growing and there is a desire to automate the many trivial manual stages of in-silico experiments. Agent-oriented software development is one approach to tackling the design of complex applications. In this paper, we argue that, in fact, agent-oriented development is a particularly well-suited approach to developing bioinformatics tools that take into account the wider domain characteristics. To illustrate this, we design a data curation tool, which manages the format of experimental data, extend it to better account for the extra requirements placed by the domain characteristics, and show how the characteristics lead to a system well suited to an agent-oriented view.
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Notification Services mediate between information publishers and consumers that wish to subscribe to periodic updates. In many cases, however, there is a mismatch between the dissemination of these updates and the delivery preferences of the consumer, often in terms of frequency of delivery, quality, etc. In this paper, we present an automated negotiation engine that identifies mutually acceptable terms; we study its performance, and discuss its application to a Grid Notification Service. We also demonstrate how the negotiation engine enables users to control the Quality of Service levels they require.
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Notification Services mediate between information publishers and consumers that wish to subscribe to periodic updates. In many cases, however, there is a mismatch between the dissemination of these updates and the delivery preferences of the consumer, often in terms of frequency of delivery, quality, etc. In this paper, we present an automated negotiation engine that identifies mutually acceptable terms; we study its performance, and discuss its application to a Grid Notification Service. We also demonstrate how the negotiation engine enables users to control the Quality of Service levels they require.
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The AFN1 gene is transiently expressed in germinating oat grains. As AFN1 is not expressed in dormant oat grains during imbibition, we hypothesize that AFN1 may be involved in stimulating the germination process. Sequence analysis of an AFN1 cDNA clone indicates that the AFN1 polypeptide is similar to a previously identified abscisic acid (ABA) glucosyl transferase. This suggests that AFN1 may be acting to glucosylate ABA, thereby inactivating it. As the hormone ABA is known to inhibit germination, ABA glucosylation/inactivation could lead to germination in grains expressing AFN1. To test this hypothesis, we have constructed an expression plasmid that encodes an MBP::AFN1 (maltose binding protein) fusion protein. E. coli cells carrying the expression plasmid were found to produce the MBP::AFN1 fusion protein as a substantial fraction of total protein. We are currently in the process of purifying the MBP::AFN1 fusion protein by affinity chromatography, so that it can be assayed for ABA glucosyl transferase activity. We also wish to test the effect of AFN1 gene expression during grain imbibition on the germination behavior of the grains. To this end, we have constructed plasmids for the overexpression and RNAi-based suppression of AFN1 in transgenic plants. These plasmids have been introduced into oat cells by particle bombardment and we are in the process of regenerating transgenic plants for study.
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In this study I suggest that there are three distinct time periods mark new developments in society’s understanding of menopause, Victorian America in the mid and late nineteenth century, mid-twentieth century America, and contemporary America. This is the case not only in terms of advances in biological science, but also the ways in which the medical establishment has viewed menopause has also changed, and in terms of changes in prevalent gender assumptions. In this paper I hope to expose the ways science, history, and society has medicalized menopause, and the ways in which menopause has been viewed by individual women, their health care providers, and society as a whole more generally. I also wish to expose the fact that how we have come to think about menopause is by no means simply the result of value-free, objective science and medicine.
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O objetivo deste estudo foi avaliar o comportamento do gradiente de pressão venosa hepática (GPVH) em pacientes com cirrose. Foram estudados 83 pacientes portadores de hepatopatia crônica, com média de idade de 52,9 ± 10,1 anos, sendo 71,1% do sexo masculino. Todos realizaram estudo hemodinâmico hepático, sendo determinado o GPVH. Nestes doentes o GPVH foi analisado segundo distintas variáveis clínicas, enfatizando seu papel na avaliação da probabilidade de sangramento a partir de um nível discriminativo. Os pacientes foram seguidos em média por 16,6 ± 16,02 meses e divididos em grupos conforme o desfecho: óbito, realização de cirurgia de “shunt” porto-cava, de transplante hepático e ressangramento por ruptura de varizes de esôfago durante o seguimento, tendo sido realizadas comparações entre as médias do GPVH nos diferentes desfechos. O nível de significância estatística adotado de foi 0,05. Com os dados obtidos foram possíveis os seguintes resultados: - A média do GPVH nos pacientes com hepatopatia crônica foi de 15,26 ± 6,46 mmHg. - Não houve diferença estatística entre as médias do GPVH nos hepatopatas crônicos de etiologia alcoólica e não alcoólica. - O risco relativo para sangramento por varizes de esôfago foi maior nos pacientes com GPVH acima de 10 e 12mmHg, embora tenha havido sangramento em doentes com níveis inferiores a estes. - A média do GPVH foi significativamente maior nos pacientes que apresentaram sangramento durante o seguimento em relação àqueles que estiveram livres desta complicação. - A média do GPVH no grupo de pacientes que sangraram, que foram a óbito, que realizaram “shunt” porto-cava e que foram a transplante hepático foi significativamente maior do que aquela observada nos pacientes que evoluíram sem complicações. - Não foi identificado um nível crítico discriminativo do GPVH que estivesse relacionado ao prognóstico. - A determinação do GPVH, ressalvada uma complicação de seriedade, mostrou-se um método seguro. Dos resultados aqui observados, conclui-se que a determinação do GPVH é útil em predizer qual população de cirróticos está mais suscetível ao sangramento digestivo por ruptura de varizes, bem como em auxiliar na avaliação do prognóstico dos mesmos.
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A presente dissertação é produto de uma investigação sobre o projeto implantado na Universidade Federal do Espírito (UFES) nos anos 90, para oferecimento de Cursos de Línguas para a Comunidade (CLC). O principal objetivo desse trabalho foi analisar as etapas de desenvolvimento do projeto e os desafios encontrados durante a sua implantação. O projeto desenvolvido é pioneiro na comunidade acadêmica capixaba e são escassos os relatos sobre experiências semelhantes à dos Cursos de Línguas para a Comunidade. Por isso mesmo, o presente trabalho servirá também de registro documental sobre o próprio CLC e de proposta de um modelo a ser implantado por outras instituições. A análise das etapas de desenvolvimento do CLC e dos desafios encontrados foi feita a partir do estudo de documentos da UFES e do próprio CLC, e de registros da imprensa local sobre os conflitos gerados e de que forma os obstáculos para implantação estão sendo gerenciados. Foram feitas também diversas pesquisas através de questionários para identificação do perfil dos alunos dos cursos de idiomas oferecidos.
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Este trabalho mostra caminhos para encontrar respostas práticas e objetivas para a aplicação de teorias, conceitos e dogmas, da teoria administrativa no sistema empresarial, com foco claro no binômio empresa e mercado. É a busca de uma relação que traga maior compartilhamento de informações entre estes mundos, procurando um comportamento empresarial que atenda as necessidades de um mercado mutante e em constante alteração. Assim esperamos atenuar o nível de impacto causado pela utilização das teOlias administrativas - consagradas ao sucesso - num universo de mercado que apresenta multiplicidade de aspectos, crescimento de forma desordenada, e no caso brasileiro, uma cultura heterogênea e diversificada. Como resultado final, observou-se que a percepção das empresas pesquisa das, por meio de seus executivos, quanto à Orientação para o Mercado na relação proposta das variáveis analisadas - Capacidade de Resposta - Geração de Inteligência - Disseminação da Inteligência - Orientação para Competidorapresenta uma forte dificuldade de ação em detrimento de uma crescente Geração e disseminação de Inteligência, com preocupações quanto ao Competidor. Outros resultados encontrados no modelo proposto deixam claro que o que os executivos acreditam que suas empresas são mais orientadas para mercado do que realmente ocorre.
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Uma das principais características do hipocampo após a isquemia é a vulnerabilidade diferencial das células da região CA1 e DG à morte celular. Os neurônios granulares do DG são resistentes, enquanto que os neurônios piramidais da região CA1 são mais sensíveis. Nosso objetivo nesse estudo foi investigar o possível envolvimento da via de sinalização celular PI3K, uma via que possui efeito proliferativo e antiapoptótico, e das proteínas de choque térmico (HSPs) no fenômeno da vulnerabilidade seletiva. Para isso foram usadas culturas organotípicas de hipocampo de ratos Wistar de 6-8 dias. As culturas foram tratadas com o inibidor da PI3K, LY294002 (LY), nas doses 10μM e 50μM. A morte celular foi quantificada pela medida da incorporação de iodeto de propídeo e da atividade das caspases 3 e 7. Alterações na fosforilação e no imunoconteúdo das proteínas foram obtidas com o uso de anticorpos específicos. Os resultados mostraram que a região do DG parece responder de forma tempo dependente e precocemente à presença da droga, sugerindo uma importância da via nessa região. Para investigar se a proteína AKT, uma cinase ativada por PI3K, estava envolvida na vulnerabilidade seletiva das células às condições de privação de oxigênio e glicose (POG), medimos a fosforilação e o imunoconteúdo dessa cinase após 60 minutos de POG seguida dos tempos de recuperação de 30 minutos, 6 horas e 24 horas. Nenhuma alteração foi observada nesses parâmetros, sugerindo que , nesse caso, a fosforilação da AKT não está envolvida na vulnerabilidade seletiva. Quando o imunoconteúdo da HSP27 e da HSP70 foi investigado após as condições de POG em ambas as áreas do hipocampo, não foi observada nenhuma alteração na HSP27 nos tempos de recuperação escolhidos. Por outro lado, observou-se aumento no imunoconteúdo da HSP70 em ambas as regiões 24 horas após a exposição às condições de POG, sendo este maior no CA1. Quando as quantidades das HSPs nas duas regiões em condições basais foram comparadas, observou-se que ambas estão em maior quantidade na região do DG. Esta diferença poderia estar relacionada com a resistência à morte celular observada no DG, uma vez que, possuindo maior quantidade HSPs, estas poderiam atuar como protetoras contra a morte. Esses resultados sugerem que a via de sinalização da PI3K pode estar envolvida na vulnerabilidade seletiva observada no hipocampo em resposta à condições de POG, e esta não envolve alterações na fosforilação da AKT. Por outro lado, HSP27 e HSP70 podem estar envolvidas no fenômeno da vulnerabilidade seletiva, protegendo o DG das lesões.