Les Apontamentos de Antonio de Paula Brito

This article deals with the main characteristcs of the apontamentos, a Santiaguense caboverdean creole grammar published both in Capeverdean an Portuguese in 1887

O Caboverdiano: Uma Lingua Mundial

Este artigo pretende até que ponto a génese e a vida o idioma caboverdiano estão ligados ao fenómeno da globalização

Illustrating Yoga: from the master to the book

In dieser Auseinandersetzung mit Visualität stellen die Autorinnen und Autoren des Bandes die faszinierende Welt des Bildes an der Schnittstelle zwischen Religion und Kultur vor. Zunächst werden hermeneutische Zugänge zu Visualität erkundet, dann folgen Studien zum Blick und dessen Regulierung innerhalb religiöser Traditionen, schliesslich werden die Vielfalt visueller Medien und deren spezifische Wechselwirkungen mit Religion untersucht. Das Buch gibt mit seiner breiten Palette internationaler und interdisziplinärer Beiträge Einblick in die visuelle Welt religiöser Traditionen und leistet einen Beitrag zu einer spezifisch religionswissenschaftlichen Visualitätsforschung.

Oligopotent stem cells are distributed throughout the mammalian ocular surface.

The integrity of the cornea, the most anterior part of the eye, is indispensable for vision. Forty-five million individuals worldwide are bilaterally blind and another 135 million have severely impaired vision in both eyes because of loss of corneal transparency; treatments range from local medications to corneal transplants, and more recently to stem cell therapy. The corneal epithelium is a squamous epithelium that is constantly renewing, with a vertical turnover of 7 to 14 days in many mammals. Identification of slow cycling cells (label-retaining cells) in the limbus of the mouse has led to the notion that the limbus is the niche for the stem cells responsible for the long-term renewal of the cornea; hence, the corneal epithelium is supposedly renewed by cells generated at and migrating from the limbus, in marked opposition to other squamous epithelia in which each resident stem cell has in charge a limited area of epithelium. Here we show that the corneal epithelium of the mouse can be serially transplanted, is self-maintained and contains oligopotent stem cells with the capacity to generate goblet cells if provided with a conjunctival environment. Furthermore, the entire ocular surface of the pig, including the cornea, contains oligopotent stem cells (holoclones) with the capacity to generate individual colonies of corneal and conjunctival cells. Therefore, the limbus is not the only niche for corneal stem cells and corneal renewal is not different from other squamous epithelia. We propose a model that unifies our observations with the literature and explains why the limbal region is enriched in stem cells.

Rapid affinity purification of erythropoietin from biological samples using disposable monoliths.

Identification of post-translational modifications of proteins in biological samples often requires access to preanalytical purification and concentration methods. In the purification step high or low molecular weight substances can be removed by size exclusion filters, and high abundant proteins can be removed, or low abundant proteins can be enriched, by specific capturing tools. In this paper is described the experience and results obtained with a recently emerged and easy-to-use affinity purification kit for enrichment of the low amounts of EPO found in urine and plasma specimens. The kit can be used as a pre-step in the EPO doping control procedure, as an alternative to the commonly used ultrafiltration, for detecting aberrantly glycosylated isoforms. The commercially available affinity purification kit contains small disposable anti-EPO monolith columns (6 ?L volume, Ø7 mm, length 0.15 mm) together with all required buffers. A 24-channel vacuum manifold was used for simultaneous processing of samples. The column concentrated EPO from 20 mL urine down to 55 ?L eluate with a concentration factor of 240 times, while roughly 99.7% of non-relevant urine proteins were removed. The recoveries of Neorecormon (epoetin beta), and the EPO analogues Aranesp and Mircera applied to buffer were high, 76%, 67% and 57%, respectively. The recovery of endogenous EPO from human urine was 65%. High recoveries were also obtained when purifying human, mouse and equine EPO from serum, and human EPO from cerebrospinal fluid. Evaluation with the accredited EPO doping control method based on isoelectric focusing (IEF) showed that the affinity purification procedure did not change the isoform distribution for rhEPO, Aranesp, Mircera or endogenous EPO. The kit should be particularly useful for applications in which it is essential to avoid carry-over effects, a problem commonly encountered with conventional particle-based affinity columns. The encouraging results with EPO propose that similar affinity monoliths, with the appropriate antibodies, should constitute useful tools for general applications in sample preparation, not only for doping control of EPO and other hormones such as growth hormone and insulin but also for the study of post-translational modifications of other low abundance proteins in biological and clinical research, and for sample preparation prior to in vitro diagnostics.

Archives curieuses de l'histoire de France.... 1re série. Tome 8e

Comprend : Histoire contenant un abrégé de la vie, moeurs et vertus du roy... Charles IX... ; La Prinse du Comte de Montgommery, dedans le chasteau de Donfron, par monsieur de Matignon, lieutenant en la basse Normandie, en l'absence du Duc de Bouillon, le Ieudy XXVII de May, mil cinq cens soixante et quatorze. A Paris, pour Nicolas du Mont demeurant auprès le Collège de Reims 1574 ; Arrest contre Geoffroy Vallée. 8 février 1574. (Extrait des Registres du Parlement) ; Discours de la mort et exécution de Gabriel Comte de Montgommery, par arrest de la Court, pour les conspirations et menées par luy commises, contre le Roy et son estat, qui fut à Paris, le vingsixième de Iuing, 1574. A Paris, par Michel Buffet... 1574 ; Choses notables et qui semblent digne de l'histoire, advenues aux premiers troubles et qui peuvent estre adjoustées aux discours qui en on esté escrits ; Histoire de Charles IX ; Le Tumulte de Bassigni... ; Discours de la famine de Sancerre. Mars 1573 ; Lettre... au roy, 27 septembre 1572 ; Des mines d'argent trouvées en France, ouvrage et police d'icelles... ; Ordonnances... sur la discipline militaire

Toward a Statistically Robust Assessment of Social and Solidarity Economy Actors. Conceptual Development and Empirical Validation

Many definitions and debates exist about the core characteristics of social and solidarity economy (SSE) and its actors. Among others, legal forms, profit, geographical scope, and size as criteria for identifying SSE actors often reveal dissents among SSE scholars. Instead of using a dichotomous, either-in-or-out definition of SSE actors, this paper presents an assessment tool that takes into account multiple dimensions to offer a more comprehensive and nuanced view of the field. We first define the core dimensions of the assessment tool by synthesizing the multiple indicators found in the literature. We then empirically test these dimensions and their interrelatedness and seek to identify potential clusters of actors. Finally we discuss the practical implications of our model.