"Auri sacra fames!" (manuscript essay), 1798 June 8

Three-page handwritten essay in English by Buckminster on wealth, greed, and economy. The essay is titled with a quote from Virgil that can be translated, "The accursed greed for gold." The essay begins, "The passion for wealth is, like every other passion, often carried to an extreme." The document has edits and struck-through words.

"Ingenuas didicisse fideliter artes Emollit mores, nec sinit esse seros" (manuscript essay), 1798 December 6

Three-page handwritten essay in English by Buckminster on the role of the arts in humanity's progress. The essay is titled with a quote from Ovid that can be translated, "A faithful study of the liberal arts refines the manners and corrects their harshness." The essay begins, "To a philosophic mind it is highly interesting to mark the progress of refinement."

"A competence is vital to content; Much wealth is corpulence, if not disease" (manuscript essay), 1799 March 30

Three-page handwritten essay in English by Buckminster with a story about a wealthy young Englishman named Francis who discovers that money is not the source of happiness. The essay is titled with a quote from Edward Young's poem, "The Complaint." Buckminster's essay begins, "Francis was the son of a rich English nobleman."

"Conscience is the best casuist" (manuscript essay), 1799 September 10

Three-page handwritten essay in English by Buckminster on the subject of conscience told through a story about a young man named Henry who saves a starving woman. The essay begins, "The disquisitions of the metaphysical world upon the origin and nature of conscience are quite unnecessary to a complete comprehension of the significancy of our motto." The essay is titled with a quote from Jean-Jacques Rousseau's Emile, Or on Education.

"Procrastination is the thief of time" (manuscript essay), 1799 November 26

Four-page handwritten essay in English by Buckminster on the consequences of procrastination. The essay begins, "Moralists of every age & nation, from wise, proverbial Solomon to 'poor Richard' of our own times, have united in recommending industry, as one of the most necessary virtues." The essay is titled with a quote from Edward Young's poem, "The Complaint," and ends with two lines from Horace beginning, "Est modus in rebus ; sunt certi denique fines..."

Bond of Samuel Leighton and Samuel Shapleigh to the Harvard Corporation, Aug. 23, 1785

Shapleigh and Leighton's signatures have been cut out from the bottom of this document. It was "signed, sealed and delivered" in the presence of Benjamin Stevens and Ebenezer Marriner.

Student compositions of Washington Allston, 1799

Handwritten essay about procrastination and a poem celebrating spring composed by Washington Allston while he was an undergraduate at Harvard. The essay uses a story about a young Italian named Bernardo to discuss the consequences of procrastination. The essay is labeled “Allston Novem. ’99" and is titled with a quote from Edward Young's poem "The Complaint," “Procrastination is Theif [sic] of time.” Allston’s poem celebrates spring and incorporates Phillida and Corydon, two characters from Nicholas Breton’s poem “Phillida and Cordion.” The poem is titled with the verses, “Chief, lovely spring, in thee, and thy soft scenes, / The smiling God is seen” from James Thompson's poem “Spring.” The poem is labeled "Allston July 10, 1799."

Sermon at the annual Dudleian lecture, May 13th, 1772

The hand-sewn notebook contains a 108-page manuscript draft of the Dudleian lecture delivered by Benjamin Stevens on May 13, 1772 at Harvard College. The sermon begins with the Biblical text Heb. 1:1, 2. The copy includes a small number of edits and struck-out words. The cover page is no longer attached.

Rhode Island, 1832 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: A topographical map of the state of Rhode Island and Providence plantations, surveyed trigonometrically and in detail by James Stevens, topographer and civil engineer, Newport, R.I. 1831. It was published by James Stevens in 1832. Scale [ca. 1: 95,040]. The image inside the map neatline is georeferenced to the surface of the earth and fit to the Rhode Island NAD 1983 coordinate system (in Feet) (Fipszone 3800). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, index maps, legends, or other information associated with the principal map. This map shows features such as roads, drainage, public buildings, schools, hotels, banks, industry locations (e.g. mills, factories, mines, etc.), selected private buildings with names of property owners, town and county boundaries, canals, and more. Relief shown by hachures. Depths shown by soundings. Includes Census statistics and "Remarks".This layer is part of a selection of digitally scanned and georeferenced historic maps from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of originators, ground condition dates, scales, and map purposes.

Massachusetts, Connecticut, and Rhode Island, 1825 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Map of Massachusetts, Connecticut and Rhode Island : constructed from the latest authorities, drawn by D.H. Vance ; engraved by J.H. Young. It was published by A. Finley in 1825. Scale [ca. 1:700,000]. Covers also portions of New York, New Jersey, Vermont, and New Hampshire. The image inside the map neatline is georeferenced to the surface of the earth and fit to the USA Contiguous Albers Equal Area Conic projection (Meters). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, drainage, state, county, and town boundaries, and more. Relief is shown pictorially. Includes statistical table. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

Réduction des artéfacts de tuteur coronarien au moyen d’un algorithme de reconstruction avec renforcement des bords : étude prospective transversale en tomodensitométrie 256 coupes

Les artéfacts métalliques entraînent un épaississement artéfactuel de la paroi des tuteurs en tomodensitométrie (TDM) avec réduction apparente de leur lumière. Cette étude transversale prospective, devis mesures répétées et observateurs avec méthode en aveugle, chez 24 patients consécutifs/71 tuteurs coronariens a pour objectif de comparer l’épaisseur de paroi des tuteurs en TDM après reconstruction par un algorithme avec renforcement des bords et un algorithme standard. Une angiographie coronarienne par TDM 256 coupes a été réalisée, avec reconstruction par algorithmes avec renforcement des bords et standard. L’épaisseur de paroi des tuteurs était mesurée par méthodes orthogonale (diamètres) et circonférentielle (circonférences). La qualité d’image des tuteurs était évaluée par échelle ordinale, et les données analysées par modèles linéaire mixte et régression logistique des cotes proportionnelles. L’épaisseur de paroi des tuteurs était inférieure avec l’algorithme avec renforcement des bords comparé à l’algorithme standard, avec les méthodes orthogonale (0,97±0,02 vs 1,09±0,03 mm, respectivement; p<0,001) et circonférentielle (1,13±0,02 vs 1,21±0,02 mm, respectivement; p<0,001). Le premier causait moins de surestimation par rapport à l’épaisseur nominale comparé au second, avec méthodes orthogonale (0,89±0,19 vs 1,00±0,26 mm, respectivement; p<0,001) et circonférentielle (1,06±0,26 vs 1,13±0,31 mm, respectivement; p=0,005) et diminuait de 6 % la surestimation. Les scores de qualité étaient meilleurs avec l’algorithme avec renforcement des bords (OR 3,71; IC 95% 2,33–5,92; p<0,001). En conclusion, la reconstruction des images avec l’algorithme avec renforcement des bords génère des parois de tuteurs plus minces, moins de surestimation, et de meilleurs scores de qualité d’image que l’algorithme standard.

Genetic association of CD247 (CD3ζ) with SLE in a large-scale multiethnic study

A classic T-cell phenotype in systemic lupus erythematosus (SLE) is the downregulation and replacement of the CD3ζ chain that alters T-cell receptor signaling. However, genetic associations with SLE in the human CD247 locus that encodes CD3ζ are not well established and require replication in independent cohorts. Our aim was therefore to examine, localize and validate CD247-SLE association in a large multiethnic population. We typed 44 contiguous CD247 single-nucleotide polymorphisms (SNPs) in 8922 SLE patients and 8077 controls from four ethnically distinct populations. The strongest associations were found in the Asian population (11 SNPs in intron 1, 4.99 × 10(-4) < P < 4.15 × 10(-2)), where we further identified a five-marker haplotype (rs12141731-rs2949655-rs16859085-rs12144621-rs858554; G-G-A-G-A; P(hap) = 2.12 × 10(-5)) that exceeded the most associated single SNP rs858554 (minor allele frequency in controls = 13%; P = 4.99 × 10(-4), odds ratio = 1.32) in significance. Imputation and subsequent association analysis showed evidence of association (P < 0.05) at 27 additional SNPs within intron 1. Cross-ethnic meta-analysis, assuming an additive genetic model adjusted for population proportions, showed five SNPs with significant P-values (1.40 × 10(-3) < P< 3.97 × 10(-2)), with one (rs704848) remaining significant after Bonferroni correction (P(meta) = 2.66 × 10(-2)). Our study independently confirms and extends the association of SLE with CD247, which is shared by various autoimmune disorders and supports a common T-cell-mediated mechanism.

Sm-Nd isotope and Mn/Ca ratios for cleaned Neogloboquadrina pachyderma from ODP Hole 105-647A (Table 1)

The neodymium (Nd) isotope composition of ancient seawater is a potentially useful tracer of changes in continental inputs and ocean circulation on timescales of a few ka. Here we present the first Nd isotope record for seawater using sedimentary foraminifera cleaned using standard oxidative-reductive techniques. The data, along with Mn/Ca ratios, suggest that cleaned foraminifera provide a reliable record of Nd in seawater and hold out the prospect of using Nd in foraminifera to examine changes in seawater that accompany glacial-interglacial climatic cycles. The principal potential problem to be overcome with the use of forams as records of trace elements in ancient seawater is their diagenetic Fe-Mn coatings. These contain large amounts of Nd and other trace elements but can be cleaned off using highly reducing reagents. Mn(Ca ratios for the majority of the cleaned sedimentary foraminifera analysed here lie within the range (10-100 µmol/mol) that has yielded success in studies of transition elements in forams. Mass-balance modelling suggests that for residual Mn/Ca ratios <100 µmol/mol, Nd added to the foram in the coating will never shift the measured Nd isotope composition significantly away from the seawater value acquired by the foram test in the water column. Additionally, Nd concentrations measured in cleaned sedimentary foraminifera are comparable with those for a modern sample that has never encountered diagenetic fluids. Finally, core-top planktonic foraminifera for two sites have Nd isotope compositions that are identical to local surface seawater. The data we present here for Labrador Sea forams over the past 2.5 m.y. are interpreted in terms of changes in the seawater isotopic composition. The data show a pronounced shift from epsilon-Nd values of ~-12 to ~-19 in the period 2.5-1.5 Ma. This change is interpreted to result from the initiation of Northern Hemisphere glaciation and the increased derivation of Labrador Sea Nd via ice-rafting from Archaean terranes in central Canada. In combination with stable isotope and foraminiferal relative species abundance data, the new Nd data are consistent with the surface hydrography of the Labrador Sea being dominated by a fluctuating balance between cold, polar waters containing unradiogenic Nd and warm, subtropical waters containing more radiogenic Nd. The major change in Labrador Sea Nd that is observed in the past 2.5 Ma can, on its own, account for the change in the Nd isotope composition of North Atlantic Deep Water over the same time period.

(Table 1) AMS radiocarbon ages from ODP Sites 169-1033 and 169-1034

This paper explores the paleoseismic record potentially preserved in the upper 40 m of hydraulic piston cores collected in 1996 at two sites in Saanich Inlet, British Columbia, during ocean drilling program (ODP) Leg 169S. The ODP cores are missing 1-2 m of water-rich sediment directly underlying the seafloor, but this sediment is preserved in shorter piston cores collected in 1989 and 1991. The upper part of the ODP cores consists of rhythmically laminated (varved) marine mud with intercalated massive beds, interpreted to be debris flow deposits. Some of the debris flow deposits are linked to past earthquakes, including the 1946 Vancouver Island earthquake (M7.2), a great (M8-9) plate-boundary earthquake at the Cascadia subduction zone in January 1700, and a large crustal or plate-boundary earthquake about 1000 yr ago. Earthquakes may also be responsible for debris flows in about AD 1600, 1500, 1250, 1150, 850, 450, 350, 180, and BC 200, 220, 500, 900, and 1050. If so, the average recurrence interval for moderate to large earthquakes, which trigger debris flows in Saanich Inlet, is about 150 yr. This recurrence interval is broadly consistent with the frequency of moderate to large earthquakes in the region during the historical period. Debris flows, however, can also be triggered by non-seismic processes, making it difficult to assemble a complete earthquake record from the Saanich Inlet cores. We propose that extensive debris flow deposits, emplaced by single large failures or many smaller coincident failures, probably have a seismic origin.