Cartas enviadas por Enrique Areilza a Justo Garate entre 1924 y 1925

3 cartas (manuscritas) ; entre 210x215mm y 250x207mm. Caja 1 - Carpeta 44

Carta enviada por Darío de Areitio a Justo Garate en 1948

1 carta (mecanografiada) ; 225x160mm. Ubicación: Caja 1 - Carpeta 45

Cartas enviadas por Gabriel Aresti a Justo Garate entre 1960 y 1968

1 nota y 3 cartas (manuscritas) ; entre 155x047mm y 210x295mm. Caja 1 - Carpeta 47

Cartas enviadas por Iñaqui el Argentino a Justo Garate entre 1962 y 1963

3 cartas (manuscritas) ; entre 220x280mm y 160x220mm. Caja 1 - Carpeta 48

Carta enviada por Luis Arregi a Justo Garate en 1988

1 carta (manuscrita) ; 161x225mm. Ubicación: Caja 1 - Carpeta 57

Cartas enviadas por Cristobal de Arrese a Justo Garate entre 1950 y 1951

2 cartas (mecanografiadas) ; 225x165mm. Ubicación: Caja 1 - Carpeta 59

Carta enviada por Florita Arrese a Justo Garate en 1938

1 carta (manuscrita) ; 215x135mm. Ubicación: Caja 1 - Carpeta 60

Tarjeta de visita enviada por Nicolás Arrieta Otazua a Justo Garate en 1955

1 tarjeta de visita firmada ; Ubicación: Caja 1 - Carpeta 63

Celiac disease in the Mediterranean area

Background: The World Gastroenterology Organization recommends developing national guidelines for the diagnosis of Celiac Disease (CD): hence a profile of the diagnosis of CD in each country is required. We aim to describe a cross-sectional picture of the clinical features and diagnostic facilities in 16 countries of the Mediterranean basin. Since a new ESPGHAN diagnostic protocol was recently published, our secondary aim is to estimate how many cases in the same area could be identified without a small intestinal biopsy. Methods: By a stratified cross-sectional retrospective study design, we examined clinical, histological and laboratory data from 749 consecutive unselected CD children diagnosed by national referral centers. Results: The vast majority of cases were diagnosed before the age of 10 (median: 5 years), affected by diarrhea, weight loss and food refusal, as expected. Only 59 cases (7.8%) did not suffer of major complaints. Tissue transglutaminase (tTG) assay was available, but one-third of centers reported financial constraints in the regular purchase of the assay kits. 252 cases (33.6%) showed tTG values over 10 times the local normal limit. Endomysial antibodies and HLA typing were routinely available in only half of the centers. CD was mainly diagnosed from small intestinal biopsy, available in all centers. Based on these data, only 154/749 cases (20.5%) would have qualified for a diagnosis of CD without a small intestinal biopsy, according to the new ESPGHAN protocol. Conclusions: This cross-sectional study of CD in the Mediterranean referral centers offers a puzzling picture of the capacities to deal with the emerging epidemic of CD in the area, giving a substantive support to the World Gastroenterology Organization guidelines.

Carta enviada por Miguel Arutza a Justo Garate en 1960

1 carta (mecanografiada) ; 137x214mm. Ubicación: Caja 1 - Carpeta 68

A novel form of human disease with a protease-sensitive prion protein and heterozygosity methionine/valine at codon 129: Case report

Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare neurodegenerative disorder in humans included in the group of Transmissible Spongiform Encephalopathies or prion diseases. The vast majority of sCJD cases are molecularly classified according to the abnormal prion protein (PrPSc) conformations along with polymorphism of codon 129 of the PRNP gene. Recently, a novel human disease, termed "protease-sensitive prionopathy", has been described. This disease shows a distinct clinical and neuropathological phenotype and it is associated to an abnormal prion protein more sensitive to protease digestion. Case presentation: We report the case of a 75-year-old-man who developed a clinical course and presented pathologic lesions compatible with sporadic Creutzfeldt-Jakob disease, and biochemical findings reminiscent of "protease-sensitive prionopathy". Neuropathological examinations revealed spongiform change mainly affecting the cerebral cortex, putamen/globus pallidus and thalamus, accompanied by mild astrocytosis and microgliosis, with slight involvement of the cerebellum. Confluent vacuoles were absent. Diffuse synaptic PrP deposits in these regions were largely removed following proteinase treatment. PrP deposition, as revealed with 3F4 and 1E4 antibodies, was markedly sensitive to pre-treatment with proteinase K. Molecular analysis of PrPSc showed an abnormal prion protein more sensitive to proteinase K digestion, with a five-band pattern of 28, 24, 21, 19, and 16 kDa, and three aglycosylated isoforms of 19, 16 and 6 kDa. This PrPSc was estimated to be 80% susceptible to digestion while the pathogenic prion protein associated with classical forms of sporadic Creutzfeldt-Jakob disease were only 2% (type VV2) and 23% (type MM1) susceptible. No mutations in the PRNP gene were found and genotype for codon 129 was heterozygous methionine/valine. Conclusions: A novel form of human disease with abnormal prion protein sensitive to protease and MV at codon 129 was described. Although clinical signs were compatible with sporadic Creutzfeldt-Jakob disease, the molecular subtype with the abnormal prion protein isoforms showing enhanced protease sensitivity was reminiscent of the "protease-sensitive prionopathy". It remains to be established whether the differences found between the latter and this case are due to the polymorphism at codon 129. Different degrees of proteinase K susceptibility were easily determined with the chemical polymer detection system which could help to detect proteinase-susceptible pathologic prion protein in diseases other than the classical ones.

Cartas enviadas por Julio Atucha a Justo Garate entre 1968 y 1989

7 cartas y 1 tarjeta postal (mecanografiadas y manuscritas) ; entre 215x275mm y 160x112mm. Ubicación: Caja 1 - Carpeta 75

Tarjeta enviada por R. Azkue a Justo Garate en 1925

1 tarjeta (manuscrita) ; 136x92mm. Ubicación: Caja 1 - Carpeta 83

Design, analysis and implementation of a versatile low level radio frequency system for accelerating cavities

179 p.

Estadificación ganglionar (N) no invasiva en el cáncer de pulmón (no pequeñas células)

97 p. : il.