An Oral Health Strategy for NI - Questionnaire (PDF 187 KB)

A Consultation Document September 2004

An Oral Health Strategy for NI (PDF 893 KB)

A Consultation Document September 2004

A Five Year Physical Activity Strategy and Action Plan

A Five Year Physical Activity Strategy and Action Plan

Cefotaxime acts synergistically with levofloxacin in experimental meningitis due to penicillin-resistant pneumococci and prevents selection of levofloxacin-resistant mutants in vitro.

Cefotaxime, given in two doses (each 100 mg/kg of body weight), produced a good bactericidal activity (-0.47 Deltalog(10) CFU/ml. h) which was comparable to that of levofloxacin (-0.49 Deltalog(10) CFU/ml. h) against a penicillin-resistant pneumococcal strain WB4 in experimental meningitis. Cefotaxime combined with levofloxacin acted synergistically (-1.04 Deltalog(10) CFU/ml. h). Synergy between cefotaxime and levofloxacin was also demonstrated in vitro in time killing assays and with the checkerboard method for two penicillin-resistant strains (WB4 and KR4). Using in vitro cycling experiments, the addition of cefotaxime in sub-MIC concentrations (one-eighth of the MIC) drastically reduced levofloxacin-induced resistance in the same two strains (64-fold increase of the MIC of levofloxacin after 12 cycles versus 2-fold increase of the MIC of levofloxacin combined with cefotaxime). Mutations detected in the genes encoding topoisomerase IV (parC and parE) and gyrase (gyrA and gyrB) confirmed the levofloxacin-induced resistance in both strains. Addition of cefotaxime in low doses was able to suppress levofloxacin-induced resistance.

Making It Better - A Strategy for Pharmacy in the Community 2004

Making It Better - A Strategy for Pharmacy in the Community 2004

Making it Better - A Strategy for Pharmacy in the Community

Strategy for Pharmacy in the community

Sexual Health Promotion Strategy (PDF 180 KB)

Sexual Health Promotion Strategy

DHSSPS Strategy for Children in Need (PDF 326 KB)

Developing the Strategy

Making It Better - A Strategy for Pharmacy in the Community (PDF 233 KB)

A Strategy for Community Pharmacy (Consultation Paper)

Oral Health Strategy - General Dental Services (PDF 397KB)

Equality Impact Assessments

Developing a Regional Strategy for the Health and Personal Social Services - Appendix 1 (PDF 35KB)

Summary of Relevant Policy Reviews

Developing a Regional Strategy for the Health and Personal Social Services - Appendix 2 (PDF 20KB)

Consultation Reply Form

Developing a Regional Strategy for the Health and Personal Social Services (PDF 73KB)

2002 - 2022