Secure and Prepared Newsletter, December 4, 2007, Vol. 3, no. 21

A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management

Secure and Prepared Newsletter, May 21, 2009, Vol. 5, no. 10

A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management

Secure and Prepared Newsletter, October 22, 2009, Vol. 5, no. 21

A bi-weekly newsletter for those involved in the fields of homeland security and/or emergency management

Comparative short-term response and remission rates for tacrolimus, cyclosporine, and infliximab for steroid-refractory ulcerative colitis

BACKGROUND: Calcineurin inhibitors (cyclosporine (CsA) and tacrolimus (Tcl)) and the anti-TNF-antibody infliximab (IFX) are established therapeutic options in steroid-refractory ulcerative colitis (UC). In acute severe UC failing steroids, a randomized trial showed an 85% short term response to CsA or IFX, with avoidance of colectomy. Comparative responses to the three drugs in outpatients with steroid-refractory UC are unknown. METHOD: Response to treatment in patients with steroid-refractory moderate to severe UC was retrospectively studied in three cohorts of patients: Cohort A (n=24) treated with oral Tcl (initially 0.05mg/kg twice daily, aiming for serum trough levels of 5-10 ng/mL); Cohort B (n=19) treated with intravenous CsA 2mg/kg/daily and then oral CsA 5mg/kg/daily; Cohort C. (n= 41) treated with IFX (5mg/kg intravenously at week 0, 2, 6 and then every 8 weeks). After successful rescue therapy with Tcl or CsA, thiopurine maintenance therapy was introduced. The endpoint was evaluation of clinical remission or response at week 6, on the basis of modified Truelove-Witts severity index (MTWSI). RESULTS: After 6 weeks, 42% (10/24) of patients treated with Tcl achieved remission (MTWSI score ≤4) compared to 47% (9/ 19) on CsA and 66% (27/41) of patients treated with IFX (Tcl & CsA vs IFX p=0.127). Clinical response (decrease of MTWSI score of more than 4 points) at week 6 was reached in 25% (6/24) patients on Tcl, compared to 11% (2/19) on CsA and 20% (8/41) given IFX (p=0.484). Subgroup analysis showed the highest rates of remission in those with moderate steroid-refractory UC treated with IFX: 29% (2/7) in Tcl group compared to 50% (2/4) in CsA group and 76 % (19/25) in IFX group (Tcl &CsA vs IFX p= 0.058) Patients with severe colitis showed similar rates of remission in all three groups: 47% (8/17) on Tcl, 47% (7/ 15) on CsA and 50% (8/16) on IFX (p= 0.700). Colectomy within 6 weeks occurred in 4% (1/24) after Tcl, 5% (1/19) after CsA and 0% (0/41) after IFX. Adverse effects in the first 6 weeks were observed in 13% (3/24) on Tcl, 26% (5/19) on CsA, and 10% (4/41) on IFX (p=0.224) CONCLUSION: No significant differences in response, remission, colectomy rate or adverse events between the three agents were found, although the study is too small for definitive conclusions. There are intriguing differences, with potentially greater response to IFX in moderate, steroid-refractory UC.

AWOS in Iowa, May 21, 2009

Automated Weather Observing Systems (AWOS) collect and disseminate weather data to various sources for the primary purpose of enhancing the safety of aircraft operations in Iowa’s air transportation system. A network of 41 AWOS systems is maintained by the Iowa Department of Transportation (Iowa DOT), and strategically located at airports around Iowa to provide both geographic and airport-specific coverage. AWOS enhances aviation safety by providing critical airport weather information to pilots to be used for flight planning and in-flight decision making. The system provides real-time weather observations, including wind, visibility, current weather, sky conditions, temperature, dew point, altimeter setting, and remarks, such as density altitude and local airport conditions.

Explore Aviation in Iowa, March 21, 2003

This brochure gives you all the addresses to the aviation museum that Iowa has to offer.

Executive Order, July 21, 1925

Appointments made to be members of the Armory Board, Iowa National Guard

Executive Order, July 21, 1925

Appointments made to be aides on the staff of the Governor and Commander in Chief, Iowa National Guard

Executive Order, July 21, 1925

Appointments made to the Advisory Board, Iowa National Guard

Executive Order No. 6, February 21, 1962

Approved appointments of Judges are made.

Business Recovery Status Report #20: Presidential Disaster #1763, November 21, 2008

Safeguard Iowa Partnership launched a survey to the business community to capture the impact from the 2008 disasters. Five hundred eighty surveys were completed and compiled for the report submitted to the Rebuild Iowa Office Economic and Workforce Development Task Force on August 20, 2008.

Lottery Action, Vol. 16, No. 21

Iowa Lottery newsletter for lottery retailers.