946 resultados para Oxidoreductases Acting on Sulfur Group Donors


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Pós-graduação em Ciências Sociais - FFC

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The purpose of this paper is to examine the paratexts, mainly prefaces and notes, written by translators on writings of foreigners' travels in Brazil, with the purpose of evidencing which perspective guided their translations, if the perspective of the foreign author is adopted or if it is that of the domestic reader. The works examined were published by the Brazilian publishing house Companhia Editora Nacional in the Brasiliana Colllection. Most of the translators adopted a welcoming discourse to the author in their prefaces, but their prefaces, translations and notes reveal a certain tension between what they stated and what was effectively done, with moments of rupture in which the author's meanings are questioned and even denied. According to my analysis, this happens because the several forces acting on the translation, the author, the translator and the text to be translated, the languages involved, the reader are not working linearly, but in constant tension. As a result, different perspectives are adopted in different translations, but in the same translation there are moments in which the foreign pole is privileged and moments in which the domestic pole emerges.

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Biological activities of flavonoids have been extensively reviewed in literature. The biochemical profile of afzelin, kaempferitrin, and pterogynoside acting on reactive oxygen species was investigated in this paper. The flavonoids were able to act as scavengers of the superoxide anion, hypochlorous acid and taurine chloramine. Although flavonoids are naturally occurring substances in plants which antioxidant activities have been widely advertised as beneficial, afzelin, kaempferitrin, and pterogynoside were able to promote cytotoxic effect. In red blood cells this toxicity was enhanced, depending on flavonoids concentration, in the presence of hypochlorous acid, but reduced in the presence of 2,20 -azo-bis(2-amidinopropane) free radical. These flavonoids had also promoted the death of neutrophils, which was exacerbated when the oxidative burst was initiated by phorbol miristate acetate. Therefore, despite their well-known scavenging action toward free radicals and oxidants, these compounds could be very harmful to living organisms through their action over erythrocytes and neutrophils.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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This study aims to structurally evaluate a support of graphite pastille for the lubrication of railway wheels. The proper lubrication of wheel flanges of the railway extends the life of this component, so it is very important that this occurs lubrication to reduce the costs involved in railway maintenance. To prepar the evaluation structural will be used to International Electrotechnical Comission standard (IEC 61373) establishing which load cases should be applied to this component. The applied loads on the support (accordance with IEC) are random accelerations and accelerations due to shocks, thus simulating the conditions that exist along the route of the train. The structural analyzes are performed by the finite element method, with the aid of the Cosmos software. Thus, it is possible to determine the stresses acting on the support, and so the allowable stresses compared with the standard proposed by the AISC. The stress in the structural analyzes are lower than allowable therefore considered for the configuration presented, unexpected structural problems

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Atherosclerosis is a chronic inflammatory disease characterized by accumulation of lipid and fibrous components in arterial vessels, giving rise to atheromas. Development of Atheromatou plaques leads to arterial steatosis, triggering ischemic events. Atherotrombosis has a strong correlation with atherosclerosis, where rupture of atheromatous plaques cause release of vessel wall's pro-thrombotic components, activating platelet aggregation and thromosis. Due to the major role played by platelets on thrombus-embolic conditions, drugs that inhibit platelet aggregation demonstrate great relevance for atherothrombosis prevention, reducing patient mortality. Currently, there are a variety of drugs acting on several different targets, preventing platelet activation. However, these therapies demosntrate side effects such as thrombocytopenia, neutropenia, hemorrhage and low oral availability. Thus, the application of molecular modifications such as hybridization can produce novel, more efficient antiplatelet aggregation inhibitors. In this project we describe the synthesis and characterization of novel N-acilhydrazone compounds, acting through multiple mechanisms such as platelet calcium chelation and nitric oxide donation by furoxanic subunits. Furthermore, we demonstrate that such compounds exhibit biological activity in in vivo bleeding time, in vitro antiplatelet aggregation and in vivo antinociceptive assays. Therefore, novel N-acilhydrazone compounds demonstrate potential as antiplatelet drugs for atherothrombosis prevention.

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Psychology, and more specifically Psychoanalysis have been called to manifest themselves about current phenomena regarding gender and sexuality issues. The demand for acting on these matters has grown, partly due to the influence of media. It is possible to point out limits on the performance of these professionals for lacking a reflection on the concept of subject, the effects of a pathologization of gender and the use of a binary conception of gender.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Pós-graduação em Engenharia Civil - FEIS

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Pós-graduação em Biologia Animal - IBILCE

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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The present study proposes an initial approach to a comparative study between supporter groups from Brazil (torcidas organizadas) and Argentina (hinchadas). The text presents a thick description that points to similarities and differences, in synchronic and diachronic terms, between both groups of football spectators. The paper focuses on each group's emergence, organizational framings, logics of belonging, and most significant practices and representations. Finally, it illustrates the contributions of this research to the construction of a public sociology of regional sport.

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The effects of stocking density and food restriction in juvenile piapara (Leporinus elongatus) were studied by two experiments. In the first, 88 piaparas juveniles were stocked in three densities (0.13, 0.20 and 0.40 fish L-1) for 70 days. Were evaluated: weight gain, average consumption, specific growth rate and feed conversion. The experiment was conducted in completely randomized design with three treatments (0.13, 0.20 and 0.40 fish L-1) and four replicates. In the second experiment, 84 fish were divided into three treatments (RBD, with 4 replicates): control group (daily food); FDS group (animals fed on weekends) and Res 21 group (animals subjected to food restriction for 21 days). Highest stocking density resulted highest biomass produced. Fish subjected to food restriction for 21 days and animals fed on weekends group, displayed full compensatory growth.