Changes of the mucosal N3 and N6 fatty acid status occur early in the colorectal adenoma-carcinoma sequence

Despite data favouring a role of dietary fat in colonic carcinogenesis, no study has focused on tissue n3 and n6 fatty acid (FA) status in human colon adenoma-carcinoma sequence. Thus, FA profile was measured in plasma phospholipids of patients with colorectal cancer (n = 22), sporadic adenoma (n = 27), and normal colon (n = 12) (control group). Additionally, mucosal FAs were assessed in both diseased and normal mucosa of cancer (n = 15) and adenoma (n = 21) patients, and from normal mucosa of controls (n = 8). There were no differences in FA profile of both plasma phospholipids and normal mucosa, between adenoma and control patients. There were considerable differences, however, in FAs between diseased and paired normal mucosa of adenoma patients, with increases of linoleic (p = 0.02), dihomogammalinolenic (p = 0.014), and eicosapentaenoic (p = 0.012) acids, and decreases of alpha linolenic (p = 0.001) and arachidonic (p = 0.02) acids in diseased mucosa. A stepwise reduction of eicosapentaenoic acid concentrations in diseased mucosa from benign adenoma to the most advanced colon cancer was seen (p = 0.009). Cancer patients showed lower alpha linolenate (p = 0.002) and higher dihomogammalinolenate (p = 0.003) in diseased than in paired normal mucosa. In conclusion changes in tissue n3 and n6 FA status might participate in the early phases of the human colorectal carcinogenesis.

Reassessing the status of antiphospholipid syndrome in systemic lupus erythematosus.

The antiphospholipid syndrome was initially described in 1986. To reassess the validity of antiphospholipid antibodies in systemic lupus erythematosus (SLE), 95 patients with SLE were studied. Their antiphospholipid antibody profile was analysed and correlated with clinical findings such as thrombosis, abortions, or thrombocytopenia. A low prevalence of these antibodies was found (13 patients; 14%) with a high specificity for thrombosis (92%) and abortions (92%). The importance of anticardiolipin antibodies as a risk factor for thrombosis or abortions, or both, in patients with SLE is reaffirmed by this work.

Epigenetic regulation of histone H3 serine 10 phosphorylation status by HCF-1 proteins in C. elegans and mammalian cells.

BACKGROUND: The human herpes simplex virus (HSV) host cell factor HCF-1 is a transcriptional coregulator that associates with both histone methyl- and acetyltransferases, and a histone deacetylase and regulates cell proliferation and division. In HSV-infected cells, HCF-1 associates with the viral protein VP16 to promote formation of a multiprotein-DNA transcriptional activator complex. The ability of HCF proteins to stabilize this VP16-induced complex has been conserved in diverse animal species including Drosophila melanogaster and Caenorhabditis elegans suggesting that VP16 targets a conserved cellular function of HCF-1. METHODOLOGY/PRINCIPAL FINDINGS: To investigate the role of HCF proteins in animal development, we have characterized the effects of loss of the HCF-1 homolog in C. elegans, called Ce HCF-1. Two large hcf-1 deletion mutants (pk924 and ok559) are viable but display reduced fertility. Loss of Ce HCF-1 protein at reduced temperatures (e.g., 12 degrees C), however, leads to a high incidence of embryonic lethality and early embryonic mitotic and cytokinetic defects reminiscent of mammalian cell-division defects upon loss of HCF-1 function. Even when viable, however, at normal temperature, mutant embryos display reduced levels of phospho-histone H3 serine 10 (H3S10P), a modification implicated in both transcriptional and mitotic regulation. Mammalian cells with defective HCF-1 also display defects in mitotic H3S10P status. CONCLUSIONS/SIGNIFICANCE: These results suggest that HCF-1 proteins possess conserved roles in the regulation of cell division and mitotic histone phosphorylation.

The health status of children without resident permit consulting the Children's Hospital of Lausanne.

OBJECTIVE: To assess social, economic and medical data concerning children without a resident permit taken into care by the Children's Hospital of Lausanne (HEL) in order to evaluate their specific needs. METHODS: Prospective exploratory study by a questionnaire including the socio-demographic, medical and education data of 103 children without a resident permit, who consulted the HEL for the first time between August 2003 and March 2006. These children were then recalled for a second check-up one year later in order to allow a regular monitoring. RESULTS: Eighty-seven percent of the children were native of Latin America, 36% being less than two years old. This population of children lived in precarious conditions with a family income lower than the poverty level (89% of the families with less than 3100 CHF/month). Forty-five percent of the children had a health insurance. The main reasons for consultation were infectious diseases, a check-up requested by the school or a check-up concerning newborn children. Most of them were in good health and the others were affected by illnesses similar to those found in other children of the same age. At least 13% of the children were obese and 27% were overweight. All children who were of educational age went to school during the year after the first check-up and 48% were affiliated to a health insurance. CONCLUSIONS: The majority of the children from Latin America lived in very precarious conditions. Their general health status was good and most of them could benefit from regular check-ups. Prevention, focused on a healthier life style, was particularly important among this population characterised by a high incidence of overweight and obesity.

Road Use Tax Fund Efficiency Report Savings Status, December 31,

Develop, in conjunction with the regional planning affiliations and metropolitan planning organizations and other stakeholder groups, a process to exchange STP federal funds for Primary Highway System funds for the purpose of reducing the number of small projects that have to meet onerous federal requirements. In order to implement this recommendation, legislative action is required to eliminate the restriction on using Primary Road Fund revenue on local jurisdiction roadways in exchange for a portion of their federal STP funding. This past session, Iowa DOT worked with legislators to introduce a bill in both the House and the Senate to eliminate this Code restriction. Bills were discussed at the subcommittee level in both the House and Senate but did not proceed because of the need to have further discussions with impacted parties. Prior to next session, discussions will occur amongst all impacted parties to reach consensus on how this recommendation could be implemented. With that consensus in place prior to next session, it is anticipated that the bills can be reintroduced next session.

Infrastructure Annual Status Report - January 2013

This is the Iowa Department of Transportation’s summary of project status for infrastructure projects that have been appropriated revenue from various funds including Rebuild Iowa Infrastructure, Health Restricted Capitals, Bridge Safety, Revenue Bonds Capitals, and Revenue Bonds Capitals II.

Midwest Regional Rail Passenger Initiative and Passenger Rail Service in Iowa Status Report

This report provides the status of the Passenger Rail Service Revolving Fund and the development and operation of the midwest regional rail system and the state's passenger rail service.

Mudança no conhecimento e na profissão acadêmica em Portugal

O propósito principal deste artigo é analisar como os acadêmicos portugueses estão lidando com as novas condições de produção de conhecimento científico ligadas à emergência da sociedade/economia do conhecimento e à crescente mercantilização e "managerização" da educação superior. Os desafios profissionais instituídos por essas novas condições podem erodir a autonomia e liberdade dos acadêmicos, construídas graças ao conhecimento científico e à colegialidade. De acordo com os resultados de uma pesquisa internacional na qual se apoia a componente empírica deste artigo, a maioria dos acadêmicos ouvidos continua vinculada aos princípios humboldtianos/mertonianos de produção do conhecimento, como base de referência do profissionalismo acadêmico. Contudo, os acadêmicos assumiram, igualmente, posições híbridas em relação à categorização epistemológica da pesquisa científica, à articulação entre a pesquisa e ensino e à filiação disciplinar, departamental e institucional.

Empoderamento dos professores entre direito à educação e mudança social

O estudo argumenta que o empoderamento de professores é condição para alcançar uma educação de qualidade e mudanças sociais, mas isso vem sendo sistematicamente negligenciado pelos elaboradores de políticas e planejadores educacionais na Índia. O bom desempenho dos professores é crucial para alcançar mais amplos objetivos sociais, assim como para tornar efetiva a recente legislação que estabelece o direito à educação como um direito fundamental. O currículo do programa de Bacharelado em Educação Elementar, oferecido pela Universidade de Delhi, é discutido em detalhe para ilustrar o potencial da formação inicial de professores para alcançar tais objetivos.

Effect of drainage maintenance on the nutrient status on drained Scots pine mires

Tiivistelmä: Kunnostusojituksen vaikutus rämeiden ravinnetilaan

Escola e status racial em Cachoeira do Campo/MG no século XIX

De acordo com uma documentação que contabilizou a população de Minas Gerais, nos anos de 1830, havia um predomínio dos negros entre os alunos das escolas de instrução elementar. Neste artigo, procuramos investigar os significados dessa experiência para a população negra através da confrontação de documentos censitários do distrito de Cachoeira do Campo/MG, que se encontrava no termo de Ouro Preto, na região central da província. O procedimento de análise ocorreu a partir da separação dos domicílios em que havia o registro de crianças frequentando escolas, em 1831. Em seguida, identificamos esses domicílios na documentação de 1838 analisando a situação dos indivíduos escolarizados e de seu grupo familiar. O intervalo de sete anos entre os documentos possibilitou a avaliação dos impactos da experiência escolar, revelando, entre outras coisas, que negros escolarizados eram preferencialmente designados como pardos e estes podiam mudar de status racial, passando até mesmo a ser classificados como brancos.

Mudança estrutural no fluxo do conhecimento: a comunicação eletrônica

A estrutura da relação entre o fluxo de informação e o público a quem o conhecimento é dirigido vem se modificando com o tempo, como uma função das diferentes técnicas que operam na transferência da informação, do gerador ao receptor. O fluxo em si, uma sucessão de eventos, de um processo de mediação, entre a geração da informação por uma fonte emissora, e a aceitação da informação pela entidade receptora, realiza uma das bases conceituais que se acredita ser o cerne da ciência da informação: a geração de conhecimento no indivíduo e no seu espaço de convivência. Assim, o propósito deste artigo é mostrar que o fluxo da informação que interliga gerador e receptor vem agregando competência na transmissão, em uma relação direta com as fases por que passou o desenvolvimento do processo de transferência da informação até chegar ao tempo da comunicação eletrônica que viabiliza com maior intensidade a relação de interação que nos interessa observar.