So weit die Preßfreiheit! Preßpranger: Ein nach Laßo's Sy͏̈stem abzustrafender Redacteur: Da droben steht a Mo! - an Schlegel in der Hand ...

Welsch (Projektbearbeiter): Kritische Kommentierung des Verhaltens der Herren Lasaulx und Sepp, Abgeordnete der Frankfurter Nationalversammlung sowie der Bayerischen Landtagskammer, in einer Presseaffäre. Karikatur samt Begleittext (in Gedichtform)

Deletion of exon 8 from the EXT1 gene causes multiple osteochondromas (MO) in a family with three affected members.

Multiple osteochondromas (also called hereditary multiple exostoses) is an autosomal dominant disorder characterized by multiple cartilaginous tumors, which are caused by mutations in the genes for exostosin-1 (EXT1) and exostosin-2 (EXT2). The goal of this study was to elucidate the genetic alterations in a family with three affected members. Isolation of RNA from the patients' blood followed by reverse transcription and PCR amplification of selected fragments showed that the three patients lack a specific region of 90 bp from their EXT1 mRNA. This region corresponds to the sequence of exon 8 from the EXT1 gene. No splice site mutation was found around exon 8. However, long-range PCR amplification of the region from intron 7 to intron 8 indicated that the three patients contain a deletion of 4318 bp, which includes exon 8 and part of the flanking introns. There is evidence that the deletion was caused by non-homologous end joining because the breakpoints are not located within a repetitive element, but contain multiple copies of the deletion hotspot sequence TGRRKM. Exon 8 encodes part of the active site of the EXT1 enzyme, including the DXD signature of all UDP-sugar glycosyltransferases. It is conceivable that the mutant protein exerts a dominant negative effect on the activity of the EXT glycosyltransferase since it might interact with normal copies of the enzyme to form an inactive hetero-oligomeric complex. We suggest that sequencing of RNA might be superior to exome sequencing to detect short deletions of a single exon.

MO visualization of Pi Orbitals

In the spirit of trying to convert people to understanding atomic orbitals centered elsewhere than the origin, we continue the discussion of visualizing molecular orbitals, so called LCAO-MO, using various plotting tricks in Maple.

LCAO-MO's are not Eigenfunctions of the H_2^+ Hamiltonian

A simple LCAO-MO for the hydrogen molecule cation is tested for eigenfunctionality and found to be flawed.

Ms. Praed. 106 - De sacramentis corporis et sanguinis domini

Vorbesitzer: Dominikanerkloster Frankfurt am Main

Na 50 Nachlass Arthur Schopenhauer - 'Schopenhauer-Archiv', 106 - Antwortschreiben mit enthaltener Bitte um Klärung und Erläuterung

u.a.: Hübbe;

Sefer Divre Yaʿaḳov : kolel shishah ʿaśar derushim niflaʾim, le-moʿadim ṿe-yamim noraʾim, reʿayonot ʿamuḳim, metubalim be-maʾamre RaZaL u-meshalim metuḳim, divre ḥokhmah u-musar, orḥot tsedeḳ u-mesharim le-ʿorer

ḥubar me-iti Yaʿakov b. la.a.a. Shelomoh Ṭaṿshunsḳi

Ms.Ff.F.Stoltze 3. 106 - Brief von Eduard Hallberger an Friedrich Stoltze

Bitte um eine Biographie Wilhelm Buschs

Ms. lat. oct. 106 - [Sammelband in 7 Teilen: Konvolut aus Handschrift, Inkunabel und Postinkunabeln]

Vorbesitzer: Hieronymus Romhiltinus; Andreas Sebastian von Zehmen; Christian Albin Zahn; Freiherren von Holzhausen

Deux quatuors concertans pour clarinette, violon, alto & violoncelle undefined : oeuvre 106

comp. par J. Amon

Mus Hs 106 - Erwin

Ferd. Hiller