An examination of the Prandtl mechanism in large dimension slope failures

An alternative explanation for the modes of failure of large scale failures of open pit walls to those of classical slope stability theory is proposed that makes use of the concept of a transition zone, which is described by a modified Prandtls prism.

The people dimension in logistics and supply chain management:its role and importance

It is widely recognised that the effective application of logistics and supply chain management (SCM) has a vital role to play in European economic recovery. Experience suggests that success in achieving higher levels of supply chain integration (SCI) depends on both physical and technical components (the hard-wiring), as well as human and behavioural components (the soft-wiring). There is significant evidence that the latter has been largely neglected by the logistics and SCM community. Furthermore, it appears that the majority of supply chain improvement initiatives by practitioners have been primarily concerned with technological, structural and process issues. This chapter argues that the difficulties often encountered in attempting to put logistics and SCM theory into practice are largely a consequence of a lack of focus and understanding of the people dimension. Based on this discussion, it offers some suggestions for improvement in this area to supply chain professionals.

Putting supply chain management (SCM) theory into practice:the role and importance of the people dimension

This article deals with a number of supply chain management (SCM) issues: SCM’s “Big Idea” – integration, Divergence of Theory and Practice - the limitations of “hard-wiring”, The “Human Chain”, The Way Forward – asking the right question?

The forgotten brand personality dimension

Aaker's (1997) brand personality framework has become influential across many streams of brand personality research, but it fails to capture an important dimension that reflects consumer's anxious feelings towards brands. Consumers are increasingly evaluating brands through expressions of negative emotive language. For example, the BP oil spillage in the Gulf of Mexico stimulated negative emotions among consumers. This paper is the first to thoroughly incorporate a brand personality dimension reflective of consumer anxious tense and frustrated feelings towards brands. From the extant literature we propose and define negative brand personality. Four adjacent studies were conducted to explore, purify and refine in what form negative brand personality traits exist among consumers. This paper concludes with a conceptual model detailing the antecedent constructs to negative brand personality and behavioral consequences. © 2012.

Glutaredoxin-1 up-regulation induces soluble vascular endothelial growth factor receptor 1, attenuating post-ischemia limb revascularization

Glutaredoxin-1 (Glrx) is a cytosolic enzyme that regulates diverse cellular function by removal of GSH adducts from S-glutathionylated proteins including signaling molecules and transcription factors. Glrx is up-regulated during inflammation and diabetes. Glrx overexpression inhibits VEGF-induced endothelial cell (EC) migration. The aim was to investigate the role of up-regulated Glrx in EC angiogenic capacities and in vivo revascularization in the setting of hind limb ischemia. Glrx overexpressing EC from Glrx transgenic mice (TG) showed impaired migration and network formation and secreted higher level of soluble VEGF receptor 1 (sFlt), an antagonizing factor to VEGF. After hind limb ischemia surgery Glrx TG mice demonstrated impaired blood flow recovery, associated with lower capillary density and poorer limb motor function compared to wild type littermates. There were also higher levels of anti-angiogenic sFlt expression in the muscle and plasma of Glrx TG mice after surgery. Non-canonical Wnt5a is known to induce sFlt. Wnt5a was highly expressed in ischemic muscles and EC from Glrx TG mice, and exogenous Wnt5a induced sFlt expression and inhibited network formation in human microvascular EC. Adenoviral Glrx-induced sFlt in EC was inhibited by a competitive Wnt5a inhibitor. Furthermore, Glrx overexpression removed GSH adducts on p65 in ischemic muscle and EC, and enhanced nuclear factor kappa B (NF-kB) activity which was responsible for Wnt5a-sFlt induction. Taken together, up-regulated Glrx induces sFlt in EC via NF-kB -dependent Wnt5a, resulting in attenuated revascularization in hind limb ischemia. The Glrx-induced sFlt may be a part of mechanism of redox regulated VEGF signaling.

Application of the Artificial Intelligence Algorithms for System Analysis of Multi Dimension Physiological Data for Developing Polyparametric Information System of Public Health Diagnostics

The polyparametric intelligence information system for diagnostics human functional state in medicine and public health is developed. The essence of the system consists in polyparametric describing of human functional state with the unified set of physiological parameters and using the polyparametric cognitive model developed as the tool for a system analysis of multitude data and diagnostics of a human functional state. The model is developed on the basis of general principles geometry and symmetry by algorithms of artificial intelligence systems. The architecture of the system is represented. The model allows analyzing traditional signs - absolute values of electrophysiological parameters and new signs generated by the model – relationships of ones. The classification of physiological multidimensional data is made with a transformer of the model. The results are presented to a physician in a form of visual graph – a pattern individual functional state. This graph allows performing clinical syndrome analysis. A level of human functional state is defined in the case of the developed standard (“ideal”) functional state. The complete formalization of results makes it possible to accumulate physiological data and to analyze them by mathematics methods.

On the Mellin Transforms of Dirac’S Delta Function, The Hausdorff Dimension Function, and The Theorem by Mellin

Mathematics Subject Classification: 44A05, 46F12, 28A78

A Super-Dimension Approach in ROLAP Environments

Often the designer of ROLAP applications follows up with the question “can I create a little joiner table with just the two dimension keys and then connect that table to the fact table?” In a classic dimensional model there are two options - (a) both dimensions are modeled independently or (b) two dimensions are combined into a super-dimension with a single key. The second approach is not widely used in ROLAP environments but it is an important sparsity handling method in MOLAP systems. In ROLAP this design technique can also bring storage and performance benefits, although the model becomes more complicated. The dependency between dimensions is a key factor that the designers have to consider when choosing between the two options. In this paper we present the results of our storage and performance experiments over a real life data cubes in reference to these design approaches. Some conclusions are drawn.

Dimension Reduction of the Explanatory Variables in Multiple Linear Regression

2002 Mathematics Subject Classification: 62J05, 62G35.

Diagonalizable Complex Systems, Reduced Dimension and Hermitian Systems II

2002 Mathematics Subject Classification: 35L40

Denoising Manifolds for Dimension

2000 Mathematics Subject Classification: 68T01, 62H30, 32C09.

Asymptotic Analysis of a Schrödinger-Poisson System with Quantum Wells and Macroscopic Nonlinearities in Dimension 1

2000 Mathematics Subject Classification: 35Q02, 35Q05, 35Q10, 35B40.