The genus Ananteris Thorell, 1891 (Scorpiones, Buthidae) in southeast Brazil, with the description of three new species

A new synthesis of the geographical distribution of the genus Ananteris Thorell, 1891 (Scorpiones, Buthidae) in Brazil is proposed. Three new species, Ananteris chagasi sp. n., Ananteris kuryi sp. n., and Ananteris bernabei sp. n. are described from the States of Bahia, Espirito Santo and Minas Gerais. Only isolated records of Ananteris species where known up to now, for the States of Minas Gerais and Bahia. The record of an Ananteris species from the State of Espirito Santo is new. The total number of Ananteris species is now raised to 67 and from this, 16 species are found in Brazil. The geographical distribution of the genus is considerably enlarged in the country.

Elucidação diagnóstica da leishmaniose visceral canina pra a vigilância epidemiológica e controle desta zoonose

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Papel dos receptores Toll-Like 2 e 4 do estado nutricional em pacientes com leishmaniose visceral

Pós-graduação em Doenças Tropicais - FMB

Cutting Edge: Brazilian Pemphigus Foliaceus Anti-Desmoglein 1 Autoantibodies Cross-React with Sand Fly Salivary LJM11 Antigen

The environmental factors that contribute to the development of autoimmune diseases are largely unknown. Endemic pemphigus foliaceus in humans, known as Fogo Selvagem (FS) in Brazil, is mediated by pathogenic IgG4 autoantibodies against desmoglein 1 (Dsg1). Clusters of FS overlap with those of leishmaniasis, a disease transmitted by sand fly (Lutzomyia longipalpis) bites. In this study, we show that salivary Ags from the sand fly, and specifically the LJM11 salivary protein, are recognized by FS Abs. Anti-Dsg1 monoclonal autoantibodies derived from FS patients also cross-react with LJM11. Mice immunized with LJM11 generate anti-Dsg1 Abs. Thus, insect bites may deliver salivary Ags that initiate a cross-reactive IgG4 Ab response in genetically susceptible individuals and lead to subsequent FS. Our findings establish a clear relationship between an environmental, noninfectious Ag and the development of potentially pathogenic autoantibodies in an autoimmune disease. The Journal of Immunology, 2012, 189: 1535-1539.