The discrepancy between social isolation and loneliness as a clinically meaningful metric: findings from the Irish and English longitudinal studies of ageing (TILDA and ELSA)

Objective
Scant evidence is available on the discordance between loneliness and social isolation among older adults. We aimed to investigate this discordance and any health implications that it may have.

Method
Using nationally representative datasets from ageing cohorts in Ireland (TILDA) and England (ELSA), we created a metric of discordance between loneliness and social isolation, to which we refer as Social Asymmetry. This metric was the categorised difference between standardised scores on a scale of loneliness and a scale of social isolation, giving categories of: Concordantly Lonely and Isolated, Discordant: Robust to Loneliness, or Discordant: Susceptible to Loneliness. We used regression and multilevel modelling to identify potential relationships between Social Asymmetry and cognitive outcomes.

Results
Social Asymmetry predicted cognitive outcomes cross-sectionally and at a two-year follow-up, such that Discordant: Robust to Loneliness individuals were superior performers, but we failed to find evidence for Social Asymmetry as a predictor of cognitive trajectory over time.

Conclusions
We present a new metric and preliminary evidence of a relationship with clinical outcomes. Further research validating this metric in different populations, and evaluating its relationship with other outcomes, is warranted.

Lipoprotein-associated phospholipase A2 (Lp-PLA2) as a therapeutic target to prevent retinal vasopermeability during diabetes

Lipoprotein-associated phospholipase A2 (Lp-PLA2) hydrolyses oxidized low-density lipoproteins into proinflammatory products, which can have detrimental effects on vascular function. As a specific inhibitor of Lp-PLA2, darapladib has been shown to be protective against atherogenesis and vascular leakage in diabetic and hypercholesterolemic animal models. This study has investigated whether Lp-PLA2 and its major enzymatic product, lysophosphatidylcholine (LPC), are involved in blood-retinal barrier (BRB) damage during diabetic retinopathy. We assessed BRB protection in diabetic rats through use of species-specific analogs of darapladib. Systemic Lp-PLA2 inhibition using SB-435495 at 10 mg/kg (i.p.) effectively suppressed BRB breakdown in streptozotocin-diabetic Brown Norway rats. This inhibitory effect was comparable to intravitreal VEGF neutralization, and the protection against BRB dysfunction was additive when both targets were inhibited simultaneously. Mechanistic studies in primary brain and retinal microvascular endothelial cells, as well as occluded rat pial microvessels, showed that luminal but not abluminal LPC potently induced permeability, and that this required signaling by the VEGF receptor 2 (VEGFR2). Taken together, this study demonstrates that Lp-PLA2 inhibition can effectively prevent diabetes-mediated BRB dysfunction and that LPC impacts on the retinal vascular endothelium to induce vasopermeability via VEGFR2. Thus, Lp-PLA2 may be a useful therapeutic target for patients with diabetic macular edema (DME), perhaps in combination with currently administered anti-VEGF agents.

Long-term fish community response to a reach-scale stream restoration

At a global scale, aquatic ecosystems are being altered by human activities at a greater rate than at any other time in history. In recent years, grassroots efforts have generated interest in the restoration of degraded or destroyed aquatic habitats, especially small wetlands and streams where such projects are feasible with local resources. We present ecological management lessons learned from 17 years of monitoring the fish community response to the channel relocation and reach-level restoration of Juday Creek, a 3rd-order tributary of the St. Joseph River in Indiana, USA. The project was designed to increase habitat complexity, reverse the effects of accumulated fine sediment (< 2 mm diameter), and mitigate for the impacts of a new golf course development. The 1997 restoration consisted of new channel construction within two reaches of a 1.2-km section of Juday Creek that also contained two control reaches. A primary social goal of the golf course development and stream restoration was to avoid harm to the non-native brown trout fishery, as symbolic of community concerns for the watershed. Our long-term monitoring effort revealed that, although fine sediment increased over time in the restored reaches, habitat conditions have promoted the resurgence of native fish species. Since restoration, the fish assemblage has shifted from non-native Salmonidae (brown trout, rainbow trout) to native Centrarchidae (rock bass, largemouth bass, smallmouth bass). In addition, native, nongame species have remained stable or have increased in population abundance (e.g., Johnny darter, mottled sculpin). The results of this study demonstrate the value of learning from a restoration project to adjust management decisions that enhance environmental quality.

How do Young People with ADHD Perceive their Condition: An Interpretative Phenomenological Analysis

Attention Deficit Hyperactivity Disorder (ADHD) is one the most prevalent of childhood diagnoses. There is limited research available from the perspective of the child or young person with ADHD. The current research explored how young people perceive ADHD. A secondary aim of the study was to explore to what extent they identify with ADHD. Five participants took part in this study. Their views were explored using semi-structured interviews guided by methods from Personal Construct Psychology. The data was analysed using Interpretative Phenomenological Analysis (IPA). Data analysis suggests that the young people’s views of ADHD are complex and, at times, contradictory. Four super-ordinate themes were identified: What is ADHD?, The role and impact of others on the experience of ADHD, Identity conflict and My relationship with ADHD. The young people’s contradictory views on ADHD are reflective of portrayals of ADHD in the media. A power imbalance was also identified where the young people perceive that they play a passive role in the management of their treatment. Finally, the young people’s accounts revealed a variety of approaches taken to make sense of their condition.

An overview of research activities and achievement in Geotechnics from the Scottish Universities Geotechnics Network (SUGN)

Design of geotechnical systems is often challenging as it requires the understanding of complex soil behaviour and its influence on field-scale performance of geo-structures. To advance the scientific knowledge and the technological development in geotechnical engineering, a Scottish academic community, named Scottish Universities Geotechnics Network (SUGN), was established in 2001, composing of eight higher education institutions. The network gathers geotechnics researchers, including experimentalists as well as centrifuge, constitutive, and numerical modellers, to generate multiple synergies for building larger collaboration and wider research dissemination in and beyond Scotland. The paper will highlight the research excellence and leading work undertaken in SUGN emphasising some of the contribution to the geotechnical research community and some of the significant research outcomes.

A acupunctura como forma de controlo da ansiedade na performance e de resolução de patologias músculo-esqueléticas em músicos

As patologias músculo-esqueléticas apresentam um interesse particular nos tempos atuais, visto terem origem em atividades viciosas, nos movimentos repetitivos, no sedentarismo e na hipertonia muscular relacionada com o stresse no contexto profissional ou pessoal, que é tão comum nos músicos. Por outro lado, a performance musical requer alto nível de habilidade em diversos parâmetros, como coordenação motora, atenção e memória o que a torna numa atividade particularmente suscetível não só às patologias músculo-esqueléticas como também à ansiedade. É aqui que se introduz a acupunctura. É cada vez mais recorrente a procura das terapias complementares e/ou alternativas por parte dos músicos, em contraposição aos métodos utilizados pela medicina convencional. Dos diversos métodos da Medicina Tradicional Chinesa, a acupunctura, encontra-se, talvez entre o mais procurado. A acupunctura pode ser definida como um técnica terapêutica que tem como método predominante a introdução de agulhas na periferia do corpo humano. O efeito das agulhas será o de provocar alterações no sistema energético do paciente que resultarão em mudanças benéficas que ocorrem a nível físico. O que me traz à discussão do tema, para além da problemática das patologias músculo-esqueléticas nos músicos é o crescente número de músicos com problemas de ansiedade e a contribuição desta medicina como alternativa de tratamento.

Measurements of small ice crystals in arctic cirrus: observations from the Indirect and Semi-Direct Aerosol Campaign (ISDAC)

In-situ observations on the size and shape of particles in arctic cirrus are less common than those in mid-latitude and tropical cirrus with considerable uncertainty about the contributions of small ice crystals (maximum dimension D<50 µm) to the mass and radiative properties that impact radiative forcing. In situ measurements of small ice crystals in arctic cirrus were made during the Indirect and Semi-Direct Aerosol Campaign (ISDAC) in April 2008 during transits of the National Research Council of Canada Convair-580 between Fairbanks and Barrow, Alaska and during Mixed Phase Arctic Cloud Experiment (MPACE) in October 2004 with the University of North Dakota (UND) Citation over Barrow, Alaska. Concentrations of small ice crystals with D < 50 μm from a Cloud and Aerosol Spectrometer (CAS), a Cloud Droplet Probe (CDP), a Forward Scattering Spectrometer Probe (FSSP), and a two-dimensional stereo probe (2DS) were compared as functions of the concentrations of crystals with D > 100 μm measured by a Cloud Imaging Probe (CIP) and two-dimensional stereo probe (2DS) in order to assess whether the shattering of large ice crystals on protruding components of different probes artificially amplified measurements of small ice crystal concentrations. The dependence of the probe comparison on other variables as CIP N>100 (number concentrations greater than diameter D>100 μm),temperature, relative humidity respect to ice (RHice), dominant habit from the Cloud Particle Imager (CPI), aircraft roll, pitch, true air speed and angle of attack was examined to understand potential causes of discrepancies between probe concentrations. Data collected by these probes were also compared against the data collected by a CAS, CDP and CIP during the Tropical Warm Pool-International Cloud Experiment (TWP-ICE) and by a CAS and 2DS during the Tropical Composition, Cloud and Climate Coupling (TC4) missions. During ISDAC, the CAS and FSSP both overestimated measurements of small ice crystals compared to both the CDP and 2DS by 1-2 orders of magnitude. Further, the amount of overestimation increased with the concentrations from the CIP2 (N>100 > 0.1 L-1). There was an unexplained discrepancy in concentrations of small crystals between the CDP and 2DS during ISDAC. In addition, there was a strong dependence on RHice of the average ratios of the N3-50, CAS/N3-50,CDP, N3-50, FSSP096/N3-50,CDP, N3-50, CAS/N3-50,FSSP096, N10-50, CDP/N3-50,2DS, N10-50, FSSP096/N10-50,2DS. Continued studies are needed to understand the discrepancy of these probes.

Actualización del sistema organizacional administrativo para las áreas de planificación y desarrollo urbano, registro familiar y registro y control tributario de la Alcaldía municipal de Cojutepeque.

La Alcaldía Municipal de Cojutepeque, del departamento de Cuscatlán, se encuentra en la actualidad gobernada por la coalición FMLN y CDU en el período 2003-2006. Desde el comienzo de sus labores, la alcaldía ha venido desarrollando las funciones que le competen, realizando proyectos de beneficio para la comunidad, y para una mejor prestación de servicios. Para lo cual es necesario que cuenten con herramientas organizacionales actualizadas que le permitan al personal realizar de forma eficiente su trabajo. La presente investigación se ha realizado con el propósito de alcanzar los siguientes objetivos: OBJETIVO GENERAL Actualizar el Sistema Organizacional Administrativo de las áreas de Planificación y Desarrollo Urbano Registro y Control Tributario de la Alcaldía Municipal de Cojutepeque del Departamento de Cuscatlán para un eficaz y eficiente desempeño de las funciones Administrativas del personal de la institución. OBJETIVOS ESPECÍFICOS. 1. Conocer la situación actual de la alcaldía municipal de Cojutepeque del departamento de Cuscatlán para proponer alternativas de solución que minimicen los problemas que se pueden estar generando. 2. Determinar las causas y efectos que originan la situación problemática a través de la revisión de documentos a fin de generar una propuesta de solución viable. 3. Diseñar una propuesta de solución para la Alcaldía Municipal de Cojutepeque del Departamento de Cuscatlán que permita mejorar el desempeño de las funciones Administrativas del personal. Para realización de la investigación se utilizó el método inductivo, deductivo, análisis y síntesis. La recolección de información se hizo a través de entrevistas, cuestionarios, registros, tesis. Libros, Etc.Actualmente la alcaldía cuenta con un Plan Estratégico el cual comprende: misión, visión, manual de organización, manual de procedimiento y manual de análisis y descripción de puesto. Los cuales no se les ha dado a conocer a los empleados y no está actualizado En lo que respecta a la estructura organizativa la alcaldía cuenta con un organigrama que fue elaborado por el personal administrativo de la Alcaldía Municipal de Cojutepeque, el cual evidentemente no está actualizado. Como consecuencia la Alcaldía Municipal de Cojutepeque no cuenta con un organigrama actualizado, y mucho menos con un manual de organización, los niveles de autoridad y responsabilidad no están bien delimitados, lo que ocasiona que se genere dualidad de mando, al recibir órdenes de más de un jefe al mismo tiempo. Con base al diagnóstico efectuado se concluye y se recomienda lo siguiente: Conclusiones a. La Alcaldía Municipal de Cojutepeque no cuenta con un sistema organizacional administrativo actualizado con el que los empleados puedan desempeñar sus funciones con eficacia y eficiencia. b. Los niveles de autoridad y responsabilidad no se encuentran bien definidas lo que provoca que exista dualidad de mando. Recomendaciones a. Actualizar el sistema organizacional administrativo de la Alcaldía Municipal de Cojutepeque que permita a los empleados desempeñar sus funciones con eficacia y eficiencia. b. Se definan claramente los niveles de autoridad y responsabilidad a efecto que exista una óptima asignación de responsabilidades y de ésta manera evitar la dualidad de mando.

The manual of chess, containing the elementary principles of the game,

Mode of access: Internet.

The manual of chess: containing the elementary principles of the game; illustrated with numerous diagrams, recent games and original problems.

Mode of access: Internet.

Challening the third sector global prospects for active citizenship

This is the first book to explore the different relationships between active citizenship and civil society, particularly the third sector within civil society. In what ways can the third sector nurture active citizenship? How have the third sector and active citizenship been constructed and reconstructed both locally and internationally, over recent years? To what extent have new kinds of social connectedness, changing forms of political engagement and increasingly complex social and environmental problems influenced civil society action? Written by experts in the field, this important book draws on a range of theory and empirical studies to explore these questions in different socio-political contexts and will be a useful resource for academics and students as well as practitioners.

Towards unsettling community development

Community development was born out of a commitment to practising ways of empowering people to take collective control of their own lives. It requires profound changes in the ways in which societies are organized, and has held out the promise of heroic change. Although community development practitioners have been able to secure spaces for community development processes and policies, overall the successes of community development have been uneven and often quite modest. Indeed, the story of community development so far is one of the considerable unfinished businesses. Drawing on two research projects, this paper considers whether third-sector organizations, which are the main sites within which community development practice takes place, generate and nurture the types of active citizenship that are appropriate to community development activities. The paper develops a typology of active citizenship and considers manifestations of the types in seven countries. The applicability of the types to community development is dependent upon what form of community development is being considered. The paper argues that we need more than a settled form of community development based around social maintenance and defensive active citizenship. An unsettled and edgy community development is also needed that requires critical, proactive, visionary, cosmopolitan and active citizens who are prepared to challenge the existing power relations.

Community development today:engaging challenges through cosmopolitanism?

This article begins by outlining some of the challenges and opportunities for community development theory and practice today. Some of these have been present from the 1960s and 70s, some have been evident for several decades, others are new and some demand urgent attention. The second part of the paper notes three types of responses to the challenges. It argues the case for embracing one specific response, namely a deepening of a cosmopolitan outlook in both the theory and practice of community development. While acknowledging that community development is in someways already a cosmopolitan endeavour, the paper concludes with a call for exploration of the ways in which embracing a broader and deeper cosmopolitanism might enhance community development as it responds to contemporary challenges.

Freud, Jung and Boas: the psychoanalytic engagement with anthropology revisited

Sigmund Freud's and C. G. Jung's turn to evolutionist anthropological material after 1909 is usually seen as a logical progression of their long-term interest in such material. It is also seen that they used this material ignorant of the significant challenges to the evolutionist paradigm underpinning such material, in particular the challenges led by Franz Boas. This paper argues otherwise: that both psychologists' turnings to such material was a new development, that neither had shown great interest in such material before 1909, and that their turnings to such material, far from being taken in ignorance of the challenges to evolutionist anthropology, were engagements with those challenges, because the evolutionist paradigm lay at the base of psychoanalysis. It argues that it is no coincidence that this engagement occurred after their return from America in 1909, where they had come into first-hand contact with the challenges of Franz Boas.