Quercetin as an inhibitor of snake venom secretory phospholipase A2

As polyphenolic compounds isolated from plants extracts, flavonoids have been applied to various pharmaceutical uses in recent decades due to their anti-inflammatory, cancer preventive, and cardiovascular protective activities. In this study, we evaluated the effects of the flavonoid quercetin on Crotalus durissus terrificus secretory phospholipase A2 (sPLA2), an important protein involved in the release of arachidonic acid from phospholipid membranes. The protein was chemically modified by treatment with quercetin, which resulted in modifications in the secondary structure as evidenced through circular dichroism. In addition, quercetin was able to inhibit the enzymatic activity and some pharmacological activities of sPLA2, including its antibacterial activity, its ability to induce platelet aggregation, and its myotoxicity by approximately 40%, but was not able to reduce the inflammatory and neurotoxic activities of sPLA2. These results suggest the existence of two pharmacological sites in the protein, one that is correlated with the enzymatic site and another that is distinct from it. We also performed molecular docking to better understand the possible interactions between quercetin and sPLA2. Our docking data showed the existence of hydrogen-bonded, polar interactions and hydrophobic interactions, suggesting that other flavonoids with similar structures could bind to sPLA2. Further research is warranted to investigate the potential use of flavonoids as sPLA2 inhibitors. (C) 2010 Elsevier B.V. All rights reserved.

Estado actual de los planes de mejora en los Centros de Desarrollo Infantil Privados

Dentro de la presente investigación, se realiza un análisis de la situación actual de los centros de desarrollo infantil privados en donde se detalla el plan de mejora. El desarrollo de este trabajo de titulación pretende demostrar la viabilidad del Plan de Mejora en cuanto a fortalecer las debilidades encontradas en cada institución para ofrecerles cuidados y educación de calidad, una infraestructura adecuada, espacios lúdicos con seguridad, involucramiento de los padres en el proceso educativo y resolución de los conflictos con los niños. Esta idea surge de la necesidad de concientizar a las instituciones para un adecuado manejo de las actividades en el desarrollo del aprendizaje, encaminadas alcanzar una enseñanza de excelencia no solo a nivel académico sino en todos los aspectos que rodean al niño; a partir de la matriz del plan de mejora y de encuestas ejecutadas a directoras y docentes de cada centro, como propósito de este trabajo, se hace un análisis con los problemas más sobresalientes y con las acciones que toman para obtener resultados favorables, la factibilidad de la investigación se determinó mediante un enfoque cualitativo por medio del cual se pudo evidenciar la falta de resultados frente a las acciones tomadas dentro de los CDI, con tablas de frecuencia que demuestran claramente esto y a su vez que tanto las directoras como docentes difieren en los tipos de problemas que fueron tratados en cada establecimiento. El plan de mejora de los centros de desarrollo infantil privados consolida a una educación de calidad, siempre y cuando se trabaje conjuntamente entre directivos, docentes y padres de familia para alcanzar un nivel de educación de primera y desarrollar en el niño un rendimiento escolar de acuerdo a la reforma curricular actual.

A produção do mobiliário urbano nos espaços públicos :o desenho do mobiliário urbano nos projetos de reordenamento das orlas do Rio Grande do Norte

This work aims to analyze and evaluate the Urban furniture designed to public areas according to the Revitalization planning for Rio Grande do Norte coastland, defining visual relations among urban elements in the landscape of revitalized public urban areas with cultural, paisagistic and touristic values and the design process used for developing urban furniture to those areas, observing the incoming consequences use to that process in a specific urban context which alters use, functions, cultural images as well as social values attributed to each particular place. Environmental perceptions, legibility of local cultural references and their representation through the design of urban elements, act in a positive or negative manner over the inhabitants cognition process of some particular revitalized area, determining new use and attributions to those areas. Designs for coastal urban interventions try excessively to standardize technical media, construction materials and planning configurations, creating artificial sceneries that segregates users, imposing new structures and usage, generating, consequently, the so called non-places and burlesque regionalism. The research is divided into 4 chapters: 1) Theoretical support (Industrial design; Urban furniture; Public urban spaces; Urban image and environmental perception; Urban occupation and interventions in coastland areas); 2) Methodological procedures and data collection; 3) Analysis of Rio Grande do Norte coastal areas and their urban interventions; 4) Final considerations and Industrial Design contributions to the subject

Plan de negocios formulado para los beneficiarios de las asociaciones Asmiuq.

8 documentos : ilustraciones, fotografías a color, cuadros.

Diagnostico social Calarcá.

12 documentos : ilustraciones, fotografías.

Ilustraciones de procesos de capacitación técnica para el desarrollo de prototipos.

18 hojas : ilustraciones, fotografías a color.

Fichas técnicas de productos para exposición y mercadeo en el programa Casa Colombiana 2014 Municipios Buenavista, La Tebaida y Calarcá.

2 documentos : ilustraciones, fotografías.

Diagnóstico de calidad del desempeño de los oficios artesanales de tejeduría y cestería en guasca de plátano en los municipios de Armenia y Génova.

2 documentos : ilustraciones.

Matriz de identificación de requerimientos tecnológicos de talleres de artesanos del Quindío.

9 documentos.

O ator que canta um conto: a manipulação de parâmetros musicais na voz do ator

This research started with an investigation about the theatrical speaking. Through an empirical methodology that analyzed a practical experience of creating a play and bibliographical research, the actress/researcher investigated ways to manipulate musical parameters as tools in the creation process of the actor s voice. The actress/researcher attempted to connect theory and practice, moved by the desire to find a vocal expression in theater that unfolds as living and transforming movement. This dissertation also contains the report of pedagogical experiences, in which the actress/researcher explored strategies to teach the appropriation of musical parameters in the construction of the vocal work of the actor. Considering that speaking in theater is closer to singing than everyday speech, she concluded that the actor may compose music as a music composer does in the elaborating process of building vocal scores. Therefore, she demonstrated that it is of fundamental importance a musical training in the development of the actor.

Registros fotográficos de eventos de asesorías puntuales, capacitación técnica y desarrollo de productos.

33 hojas : ilustraciones, fotografías a color.

Reforma a seco de metano com catalisadores Ni/MCM-41 sintetizados a partir de fontes alternativas de sílica

The production of synthesis gas has received renewed attention due to demand for renewable energies to reduce the emissions of gases responsible for enhanced greenhouse effect. This work was carried out in order to synthesize, characterize and evaluate the implementation of nickel catalysts on MCM-41 in dry reforming reactions of methane. The mesoporous molecular sieves were synthesized using as silica sources the tetraethyl orthosilicate (TEOS) and residual glass powder (PV). The sieves were impregnated with 10% nickel to obtain the metallic catalysts (Ni/MCM-41). These materials were calcined and characterized by Thermogravimetric Analysis (TG), Infrared spectroscopy (FTIR), X-ray Diffraction (XRD), Temperature-Programmed Reduction (TPR) and N2 Adsorption/Desorption isotherms (BET/BJH). The catalytic properties of the samples were evaluated in methane dry reforming with CO2 in order to produce synthesis gas to be used in the petrochemical industry. The materials characterized showed hexagonal structure characteristic of mesoporous material MCM-41 type, being maintained after impregnation with nickel. The samples presented variations in the specific surface area, average volume and diameter of pores based on the type of interaction between the nickel and the mesoporous support. The result of the the catalytic tests showed conversions about 91% CO2, 86% CH4, yelds about 85% CO and 81% H2 to Ni/MCM-41_TEOS_C, and conversions about 87% CO2, 82% CH4, yelds about 70% CO and 59% H2 to Ni/MCM-41_PV_C. The similar performance confirms that the TEOS can be replaced by a less noble materials

Biologia alimentar e morfohistologia do tubo digestório do mussum, synbranchus marmoratus, bloch (osteichthyes: synbranchidae) no açude Marechal Dutra Gargalheiras , localizado no semi-árido brasileiro

Food habits and morpho-histology of the digestive tract of marbled swamp eel, Synbranchus marmoratus (Block, 1917) were investigated. The fish samples were captured during August, 2007 to July, 2008 in the Marechal Dutra reservoir, Acari, Rio Grande do Norte. The rain fall data was obtained from EMPARN. The fish captured, were measured, weighed, dissected, eviscerated and individual stomach weights were registered. The stomach contents analyses were carried out based on volumetric method, points, frequency of occurrence and applying the Index of Relative Importance. The degrees of repletion of the stomachs were determined besides the Index of Repletion relating to feeding activity variations and frequency of ingestion during the rainy and dry seasons. The rainfall varied from 0 mm a 335 mm with a mean value of 71.62 mm. Highest rainfall of 335.5 mm was registered in March, 2008 and August to December was the dry period. During the dry period the study species presented high degrees of repletion of the stomachs, with a peak value in the month of September (mean = 4.54; ± SD = 0.56). The minimum mean value of = 3.99 ± SD = 0.25 was registered in the month of May during the rainy period. The stomach contents of S. marmoratus registered show that this fish prefers animals, 78.22% of crustaceans 2.85% of mollusks, 3.25% of fish, 1.4% of insects and 13.5% of semi-digested organic matter, thus characterizing the study species as a carnivore with a preference for crustaceans. The morpho-histological aspects of the digestive tract of S. marmoratus indicate that the mouth is terminal adapted to open widely, thin lips with taste buds, small villiform teeth forming a single series on maxillas, four pairs of branchial arches with short and widely spaced branchial rays. The oesophagus is short and cylindrical with a small diameter. The oesophagus wall is thick with mucas surface and internal parallel folds. The stomach is retilinical in form, presenting cardiac, caecal and pyloric portions. The caecal portion is long and is intermediary in position between the cardiac and pyloric portions. The cardiac portion of the stomach is short and cylindrical formed of simple epithelial cylindrical mucus cells. The caecal portion is long with narrow walls, a big cavity and smaller folds which give rise to gastric glands. The phyloric portion has no glands and primary or secondary mucas folds. The morphohistological aspects of the digestive tract of S. marmoratus indicate its adaptation to a carnivorous feeding habit

Tensiones en la construcción de políticas de inclusión en el ingreso y primer año de carreras de ingeniería en la UNLP : Perspectivas e implicancias para el trabajo docente

Fil: Garatte, Luciana. Universidad Nacional de La Plata. Facultad de Humanidades y Ciencias de la Educación; Argentina.

Foucault, el liberalismo y la critica de la filosofía política

Evitando las abstracciones dicotomizadas, de la filosofía política moderna y contemporánea, Michel Foucault no ha tratado de reconstruir una totalidad trascendental, racional y normativa, ni de legitimar racionalmente los valores, sino de estudiar las prácticas de sí en una sociedad dada y las transformaciones que generan. Poner el acento sobre las prácticas autoformadoras del individuo nos dibuja toda una visión dinámica del sujeto y de la libertad que componen una cara inversa de «los cuerpos dóciles», o del sujeto producido por el entramado poder/saber. La genealogía de Foucault se puede ampliar para demostrar que el liberalismo es un conjunto de prácticas para la constitución de los sujetos. Un liberalismo, que luego de formar el programa policial para producir categorías de personas, es capaz de aportar condiciones para el juego de la libertad y regular la conducta en términos de empresarialidad.