999 resultados para Inhibidores de transcriptasa inversa


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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

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Pós-graduação em Engenharia Mecânica - FEIS

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The aim of this study was to evaluate maternal stress and anxiety and the quality of interaction of 10 mothers and their 0-3-month-old babies with Pierre Robin Sequence hospitalized in a university hospital. We used the Inventory of Stress Symptoms for Adults to evaluate stress and the State-Trait Anxiety Inventory to assess anxiety of the mothers, and a protocol to assess the recording of the mother-infant interaction. The results showed high levels of maternal stress and anxiety. A statistically significant inverse relationship was found: the higher the maternal anxiety and stress, the lower was the mother-infant interaction. The results indicate that work needs to be done to minimize the anxiety and stress of mothers with inpatient babies in order to encourage interaction.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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A trial was carried out with the purpose of evaluating the effect of different management systems applied between the rows of rubber trees (Hevea brasiliensis) on the aggregate stability in water of Dark Red Latosol, with clayey texture from the Municipality of Jaboticabal (SP) and Yellow Red Podzolic, sandy/medium texture fromthe Municipality of Tabapua (SP). The treatments consisted of disk harrowing, Pueraria phaseoloides and mowing. The soil samples were withdrawn after seven years of application of these management systems from depths of 0-0.1, 0.1-0.2, 0.2-0.3, and 0.3-0.4 m. The stability of the aggregates was obtained in sieves with size classes of 8-4, 4-2, 2-1, 1-0.5, 0.5-0.125, and < 0.125 mm. The Pueraria phaseoloides gave a significant difference regarding the distribution of the aggregates on the superficial layer (10 cm) when compared to the other management systems, presenting a higher distribution of larger sized aggregates on the Dark Red Latosol. The tillage management for this same depth presented higher values of small sized aggregates on both soils. The organic matter on the soils showed a direct and significant relation to the stability of the larger sized aggregates and an inverse relation with the stability of the smaller sized aggregates.

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Pós-graduação em Desenvolvimento Humano e Tecnologias - IBRC

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This study investigated the effect of slope and antecedent soil moisture on the water depth stored and percolated on extensive green roofs built in pilot scale. For this purpose, slopes of 10, 20 and 30% were investigated. Moisture was measured before and after each test in order to determine the differential moisture (∆U). The experimental runoff and percolated flow were analyzed by varying moisture and slope. Apparent color and turbidity were measured on runoff and percolated flow for each one of the modules. The results yielded that for the slopes of 10% the smaller values of runoff was obtained (average of 1,01% ± 0,7%). For the others slopes (20% and 30%), the runoffs were around 35% ± 15%. The sum of runoff and percolated water results in 77% (average) for slope of 10% and 80% for 20% and 30%. The slope and moisture have explained 87% of data for retained water and 81% for runoff. For percolated flow the inverse trend was observed. The retained water was 11,6±1,4mm for the module with 10% of slope, around 10,0±1,2 mm for the module with 20% of slope, and about 9,5±1,1 mm for the module with 30%. The results pointed out that both slope and antecedent moisture are crucial for runoff reduction and for material transportation.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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The mast cell tumor (MCT) is the second most common type of tumor in dogs. It is characterized by uncontrolled proliferation of mast cells in the skin. Treatment involves surgical resection, chemotherapy and radiotherapy. Recently, new treatment protocols have been developed, such as the use of tyrosine kinase inhibitors. With the increasing knowledge about the genome and the evolution of methods in molecular genetics, drugs with specific molecular targets are surely going to become promising therapeutic modalities in the near future. Besides being involved in the normal cell cycle, some studies suggest that tyrosine kinases have a fundamental role in neoplastic processes. Therefore, some strategies such as the development of antibodies anti-receptors for tyrosine kinases and small-molecule tyrosine kinase receptor inhibitors have been developed in an attempt to inhibit tumor development. The purpose of this review is to describe the use of tyrosine kinase inhibitors in the treatment of mast cell tumors in dogs.

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This research evaluated corn grains with flint and dent texture (ensiled high-moisture or dried), submitted to grinding degrees, using the in situ ruminal degradation technique. Three rumen canulated adult sheeps were used in a complete randomized design, using a factorial outline 2 x 2 x 3, with two corn hybrids (flint and dent texture), two conservation methods (ensiled high-moisture and dry) and three grinding degress (whole, coarsely and finely ground, corresponding to the sieve of 12; 10 and 8 mm). Starch soluble fraction (A) of the dent hybrid ensiled corn grains was greater comparing to the dry materials and in both conservation forms this fraction was reduced in the flint texture hybrid, while the insoluble fraction potentially degradable (B) the opposite occurred. The degradation potential was higher in grains ensiled in two textures. The ensiled allowed more starch effective degradation in relation to dry grain in two textures and the grains dent texture hybrid also increased such degradation in both conservation methods. The dent texture and the ensiled high-moisture grains proved the best option considering the starch degradability. Regardless of the conservation forms, the grains of corn hybrid flint texture should be finely ground, for providing higher ruminal degradation, while for the dent texture hybrid, the coarsely and whole grinding are the most suitable for ensiled and dry grain, respectively.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)