Tombstone of the Benno Molling family in the Jewish cemetery An der Strangriede; Hannover, Germany. Cemeteries; Tombs

This family grave is next to the tombstone of Adolf Molling and his wife Henriette (Henny) nee Meyerhof

Meyerhof family graves; Jewish cemetery; Hildesheim Cemeteries Tombs

(l-r) Ilse Meyerhof, Joel Meyerhof (father), Adolf Meyerhof

Portrait of Yael Bernkopf with her grandmother Aenny Catzenstein nee Gottschalk; Israel Portraits Family

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Margot Molling with her brother Adolf Molling; Laughlin, Nevada Portraits Family

Temperature: 117 F

Ilse Goldschmidt nee Molling with her sons Ernest and Frank Goldschhmidt on her 80th birthday; Laguna Hills, California.

Left to Right: Ernest Goldschmidt, Ilse Goldschmidt born Molling, and Frank Goldschmidt. The picture was taken on the occasion of Ilse's 80th birthday party 22 Dec 1989 Laguna Hills, CA.

Patrick and Susan Matthiesen playing chess at Aenny Catzenstein nee Gottschalk's 80th birthday; London Portraits Family

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Family and guests at Aenny Catzenstein nee Gottschalk's 80th birthday; London.

Front row l-r: Beatrice Durand, Francine Durand and Aenny Catzenstein, the boys are Ara-Serge Donabedian and Patrick Matthiesen and the adults are Susan Prior, Francis Matthiesen, Maren Matthiesen, Nino Fabri and Olga Matthiesen,

Family and guests at Aenny Catzenstein nee Gottschalk's 80th birthday party; London.

Dinner scene with Franz Mattheisen left, daughter Susan Mattheisen next to him, next daughter Maren Matthiesen, his wife Olga Matthiesen at the end of the table. Beatrice Durand is facing the camera

Genome-wide association studies of quantitative traits with related individuals: Little (power) lost but much to be gained

For complex disease genetics research in human populations, remarkable progress has been made in recent times with the publication of a number of genome-wide association scans (GWAS) and subsequent statistical replications. These studies have identified new genes and pathways implicated in disease, many of which were not known before. Given these early successes, more GWAS are being conducted and planned, both for disease and quantitative phenotypes. Many researchers and clinicians have DNA samples available on collections of families, including both cases and controls. Twin registries around the world have facilitated the collection of large numbers of families, with DNA and multiple quantitative phenotypes collected on twin pairs and their relatives. In the design of a new GWAS with a fixed budget for the number of chips, the question arises whether to include or exclude related individuals. It is commonly believed to be preferable to use unrelated individuals in the first stage of a GWAS because relatives are 'over-matched' for genotypes. In this study, we quantify that for GWAS of a quantitative phenotype, relative to a sample of unrelated individuals surprisingly little power is lost when using relatives. The advantages of using relatives are manifold, including the ability to perform more quality control, the choice to perform within-family tests of association that are robust to population stratification, and the ability to perform joint linkage and association analysis. Therefore, the advantages of using relatives in GWAS for quantitative traits may well outweigh the small disadvantage in terms of statistical power.

Gottschalk family on vacation; Norderney, Germany.

Left to right: two unidentified women, Kurt Gottschalk, Therese Gottschalk nee Molling, Fritz Gottschalk, unidentified woman (the maid?), and Elizabeth Gottschalk

Gottschalk family on vacation in front of Kurhaus Brunig; Norderney, Germany.

From left to right: man with camera: Karl Gottschalk; sitting on stairs: Fritz Gottschalk, unidentified woman, Therese Gottschalk nee Molling, Hans Ludwig, Kurt Gottschalk, unidentified woman (maid?) and Elizabeth Gottschalk

Family of Dr. Max and Helen Bejach portraits family

unidentified family members