911 resultados para Glaucome à angle ouvert


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Acknowledgements This work received funding from the Marine Alliance for Science and Technology for Scotland (MASTS) pooling initiative and their support is gratefully acknowledged. MASTS is funded by the Scottish Funding Council (grant reference HR09011) and contributing institutions. We thank Joshua Lawrence and Niall Fallon for their assistance in collecting some of the video data.

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Medical Research Council (ref G0701604) and administered by the NIHR-EME (ref 09-800-26)

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Cette note de recherche s’intéresse à l’article de Souleymane Bachir Diagne « L’avenir de la tradition » paru dans l’ouvrage Sénégal. Trajectoires d’un État, dirigé par Momar-Coumba Diop et publié par le Codesria en 1992. Quoique datée, cette étude demeure déterminante pour qui souhaite alimenter une réflexion nuancée sur l’identité collective, au Sénégal tout particulièrement, mais aussi, sur l’ensemble du continent africain trop souvent coincé dans l’antagonisme conceptuel de « la tradition contre la modernité ».

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Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

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Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

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Purpose: The exact nature of the relationship between Alzheimer’s disease (AD) and primary open angle glaucoma (POAG) is still the subject of debate. One factor attributed to the aetiology of both conditions is vascular dysfunction. This study aimed to investigate the similarities and differences in retinal microvascular function between mild AD patients, early stage POAG patients and healthy controls Methods: Retinal vessel reactivity to flickering light was assessed in 10 AD, 19 POAG and 22 healthy age matched control patients by means of dynamic retinal vessel analysis (DVA, IMEDOS, GmbH, Jena, Germany) according to an established protocol. All patients additionally underwent BP measurements and blood analysis for glucose and lipid metabolism markers Results: AD and POAG patients demonstrated comparable alterations in retinal artery reactivity, in the form of an increased arterial reaction time (RT) to flicker light on the final flicker cycle (p=0.014), which was not replicated in the healthy age and cardiovascular risk matched controls (p>0.05). Furthermore, the sequential changes in RT on progressing from flicker one to flicker three were found to differ between healthy controls and the two disease groups (p=0.001) Conclusions: AD and POAG patients demonstrate comparable signs of vascular dysfunction in their retinal arteries at the early stages of their disease process. These comparable signs may reflect similarities in the pathophysiological processes that occur in the development of both conditions

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Purpose: To investigate the effect of incorporating a beam spreading parameter in a beam angle optimization algorithm and to evaluate its efficacy for creating coplanar IMRT lung plans in conjunction with machine learning generated dose objectives.

Methods: Fifteen anonymized patient cases were each re-planned with ten values over the range of the beam spreading parameter, k, and analyzed with a Wilcoxon signed-rank test to determine whether any particular value resulted in significant improvement over the initially treated plan created by a trained dosimetrist. Dose constraints were generated by a machine learning algorithm and kept constant for each case across all k values. Parameters investigated for potential improvement included mean lung dose, V20 lung, V40 heart, 80% conformity index, and 90% conformity index.

Results: With a confidence level of 5%, treatment plans created with this method resulted in significantly better conformity indices. Dose coverage to the PTV was improved by an average of 12% over the initial plans. At the same time, these treatment plans showed no significant difference in mean lung dose, V20 lung, or V40 heart when compared to the initial plans; however, it should be noted that these results could be influenced by the small sample size of patient cases.

Conclusions: The beam angle optimization algorithm, with the inclusion of the beam spreading parameter k, increases the dose conformity of the automatically generated treatment plans over that of the initial plans without adversely affecting the dose to organs at risk. This parameter can be varied according to physician preference in order to control the tradeoff between dose conformity and OAR sparing without compromising the integrity of the plan.

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Cette note de recherche s’intéresse à l’article de Souleymane Bachir Diagne « L’avenir de la tradition » paru dans l’ouvrage Sénégal. Trajectoires d’un État, dirigé par Momar-Coumba Diop et publié par le Codesria en 1992. Quoique datée, cette étude demeure déterminante pour qui souhaite alimenter une réflexion nuancée sur l’identité collective, au Sénégal tout particulièrement, mais aussi, sur l’ensemble du continent africain trop souvent coincé dans l’antagonisme conceptuel de « la tradition contre la modernité ».

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Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.

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Mémoire numérisé par la Direction des bibliothèques de l'Université de Montréal.