JExample: Exploiting Dependencies Between Tests to Improve Defect Localization

To quickly localize defects, we want our attention to be focussed on relevant failing tests. We propose to improve defect localization by exploiting dependencies between tests, using a JUnit extension called JExample. In a case study, a monolithic white-box test suite for a complex algorithm is refactored into two traditional JUnit style tests and to JExample. Of the three refactorings, JExample reports five times fewer defect locations and slightly better performance (-8-12\%), while having similar maintenance characteristics. Compared to the original implementation, JExample greatly improves maintainability due the improved factorization following the accepted test quality guidelines. As such, JExample combines the benefits of test chains with test quality aspects of JUnit style testing.

Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies.

A wealth of genetic associations for cardiovascular and metabolic phenotypes in humans has been accumulating over the last decade, in particular a large number of loci derived from recent genome wide association studies (GWAS). True complex disease-associated loci often exert modest effects, so their delineation currently requires integration of diverse phenotypic data from large studies to ensure robust meta-analyses. We have designed a gene-centric 50 K single nucleotide polymorphism (SNP) array to assess potentially relevant loci across a range of cardiovascular, metabolic and inflammatory syndromes. The array utilizes a "cosmopolitan" tagging approach to capture the genetic diversity across approximately 2,000 loci in populations represented in the HapMap and SeattleSNPs projects. The array content is informed by GWAS of vascular and inflammatory disease, expression quantitative trait loci implicated in atherosclerosis, pathway based approaches and comprehensive literature searching. The custom flexibility of the array platform facilitated interrogation of loci at differing stringencies, according to a gene prioritization strategy that allows saturation of high priority loci with a greater density of markers than the existing GWAS tools, particularly in African HapMap samples. We also demonstrate that the IBC array can be used to complement GWAS, increasing coverage in high priority CVD-related loci across all major HapMap populations. DNA from over 200,000 extensively phenotyped individuals will be genotyped with this array with a significant portion of the generated data being released into the academic domain facilitating in silico replication attempts, analyses of rare variants and cross-cohort meta-analyses in diverse populations. These datasets will also facilitate more robust secondary analyses, such as explorations with alternative genetic models, epistasis and gene-environment interactions.

The Olive Tree, Vol. 14 Number 1, 2006

The Spring 2006 issue of The Olive Tree features articles about library projects, collections, technological innovations, and events at Fogler Library, University of Maine.

The Olive Tree, Vol. 13 Number 2, 2005

The Fall 2005 issue of The Olive Tree features articles about library projects, collections, technological innovations, and events at Fogler Library, University of Maine.

The Olive Tree, Vol. 9 Number 1, 2001

The Summer 2001 issue of The Olive Tree features articles about library projects, collections, technological innovations, and events at Fogler Library, University of Maine.

DESyne novolimus-eluting coronary stent is superior to Endeavor zotarolimus-eluting coronary stent at five-year follow-up: final results of the multicentre EXCELLA II randomised controlled trial

AIMS Newer-generation drug-eluting stents (DES) have been shown to be superior to first-generation DES. Current-generation DES have zotarolimus, everolimus or biolimus as antiproliferative drugs. Novolimus, a metabolite of sirolimus, has been specifically developed to provide efficacy similar to currently available agents at a lower dose and thus requires a lower polymer load. We report the final five-year outcomes of the EXCELLA II trial comparing a zotarolimus-eluting stent (ZES) with a novolimus-eluting stent (NES). METHODS AND RESULTS EXCELLA II is a prospective, multicentre, single-blind, non-inferiority clinical trial. Patients (n=210) with a maximum of two de novo lesions in two different epicardial vessels were randomised (2:1) to treatment with either NES (n=139) or ZES (n=71). At five-year follow-up, patients in the NES group had a significantly lower incidence of the patient-oriented (HR 0.53, 95% CI: 0.32-0.87, p=0.013) and device-oriented (HR 0.38, 95% CI: 0.17-0.83, p=0.011) composite endpoints. There was no difference in cardiac death and definite/probable stent thrombosis between the two groups; however, there was a trend towards reduction in myocardial infarction and repeat revascularisation in the NES group at five-year follow-up. CONCLUSIONS At five-year follow-up, the incidence of device- and patient-oriented events was significantly lower in the NES group. Further studies, adequately powered for clinical outcomes, are warranted. TRIAL REGISTRATION ClinicalTrials.gov number NCT00792753.

Liberalism and racism: an ‘elective affinity’?

This appraisal of David Scott FitzGerald and David Cook-Martín's Culling the Masses: The Democratic Origins of Racist Immigration Policy in the Americas argues that there is no ‘elective affinity’ between liberalism and racism, which is the core argument of the book. The notion of ‘elective affinity’, which the authors borrow from Max Weber, requires a structural homology between the ‘electively’ related elements that just does not exist in this case. The relationship between both is entirely contingent, ‘racism’ being a doctrine of inter-group relations while ‘liberalism’ is a doctrine of intra-group relations, with no consideration of how the boundaries of the group are constituted.

Escribir con Artaud : Aproximaciones deleuzianas

La literatura en el pensamiento deleuziano, es decir la "literatura menor", es revolucionaria en tanto que posibilita crear nuevas formas de vidas, de percepciones, de resistencias. En este sentido, Deleuze explora y encuentra un particular interés por diferentes escritores como Virginia Woolf, Scott Fitzgerald, Marcel Proust, Franz Kafka, Antonin Artaud, Herman Melville, entre otros. A partir de una reflexión sobre sus textos, Deleuze crea conceptos que juegan dentro de su máquina. Podemos decir que toda la filosofía de Gilles Deleuze está fuertemente atravesada, entre otras cosas, por la literatura. Nuestro trabajo se sitúa en el cruce entre la producción deleuziana y la literatura, más concretamente en el encuentro entre Artaud y Deleuze. A partir del (re)encuentro entre Artaud y Deleuze, este trabajo trata sobre la "vida" de Artaud, de cómo Artaud perfora la escritura, perforando su cuerpo; de cómo Artaud atraviesa el cuerpo de Deleuze produciendo al mismo tiempo su devenir. Si escribir, en el pensamiento deleuziano, siempre implica escribir con (alguien), escribir con Artaud no significa interpretarlo, comentarlo, sino, atravesar(se) el mismo cuerpo deleuziano

Escribir con Artaud : Aproximaciones deleuzianas

La literatura en el pensamiento deleuziano, es decir la "literatura menor", es revolucionaria en tanto que posibilita crear nuevas formas de vidas, de percepciones, de resistencias. En este sentido, Deleuze explora y encuentra un particular interés por diferentes escritores como Virginia Woolf, Scott Fitzgerald, Marcel Proust, Franz Kafka, Antonin Artaud, Herman Melville, entre otros. A partir de una reflexión sobre sus textos, Deleuze crea conceptos que juegan dentro de su máquina. Podemos decir que toda la filosofía de Gilles Deleuze está fuertemente atravesada, entre otras cosas, por la literatura. Nuestro trabajo se sitúa en el cruce entre la producción deleuziana y la literatura, más concretamente en el encuentro entre Artaud y Deleuze. A partir del (re)encuentro entre Artaud y Deleuze, este trabajo trata sobre la "vida" de Artaud, de cómo Artaud perfora la escritura, perforando su cuerpo; de cómo Artaud atraviesa el cuerpo de Deleuze produciendo al mismo tiempo su devenir. Si escribir, en el pensamiento deleuziano, siempre implica escribir con (alguien), escribir con Artaud no significa interpretarlo, comentarlo, sino, atravesar(se) el mismo cuerpo deleuziano

Escribir con Artaud : Aproximaciones deleuzianas

La literatura en el pensamiento deleuziano, es decir la "literatura menor", es revolucionaria en tanto que posibilita crear nuevas formas de vidas, de percepciones, de resistencias. En este sentido, Deleuze explora y encuentra un particular interés por diferentes escritores como Virginia Woolf, Scott Fitzgerald, Marcel Proust, Franz Kafka, Antonin Artaud, Herman Melville, entre otros. A partir de una reflexión sobre sus textos, Deleuze crea conceptos que juegan dentro de su máquina. Podemos decir que toda la filosofía de Gilles Deleuze está fuertemente atravesada, entre otras cosas, por la literatura. Nuestro trabajo se sitúa en el cruce entre la producción deleuziana y la literatura, más concretamente en el encuentro entre Artaud y Deleuze. A partir del (re)encuentro entre Artaud y Deleuze, este trabajo trata sobre la "vida" de Artaud, de cómo Artaud perfora la escritura, perforando su cuerpo; de cómo Artaud atraviesa el cuerpo de Deleuze produciendo al mismo tiempo su devenir. Si escribir, en el pensamiento deleuziano, siempre implica escribir con (alguien), escribir con Artaud no significa interpretarlo, comentarlo, sino, atravesar(se) el mismo cuerpo deleuziano

Discarge compilation from The Global River Discharge (RivDIS) Project

The Global River Discharge (RivDIS) data set contains monthly discharge measurements for 1018 stations located throughout the world. The period of record varies widely from station to station, with a mean of 21.5 years. These data were digitized from published UNESCO archives by Charles Voromarty, Balaze Fekete, and B.A. Tucker of the Complex Systems Research Center (CSRC) at the University of New Hampshire. River discharge is typically measured through the use of a rating curve that relates local water level height to discharge. This rating curve is used to estimate discharge from the observed water level. The rating curves are periodically rechecked and recalibrated through on-site measurement of discharge and river stage.