Description of the behavior of dichloroalkanes-containing solutions with three [bXmpy][4] isomer, using the experimental information of thermodynamic properties, 1H-NMR spectral and the COSMO-RS methodology

[EN]This work studies the binaries of 1-butyl-X-methylpyridinium tetrafluoroborate [bXmpy][BF4] (X = 2, 3, and 4) with four 1,ω-dichloroalkanes, ω = 1−4, using the results obtained for the mixing properties hE and v E at two temperatures. The three isomers of the ionic liquid (IL) are weakly miscible with the 1,ω-dichloroalkanes when ω ≥ 5 and moderately soluble for ω = 4. The vE s of all the binaries present contractive effects, v E < 0, which are more pronounced with increasing temperature; the variation in vE with ω is positive, although this changes after ω = 4 due to problems of immiscibility

Il repertorio italiano del Ms Gr. Rés. Vm7 676 della Biblioteca Nazionale di Parigi

La tesi esamina il codice musicale Gr. Rés Vm7 676 della Biblioteca Nazionale di Parigi, che rappresenta una fonte di grande interesse per lo studio della musica vocale italiana tra Quattro e Cinquecento. Compilato nel 1502, il codice è stato oggetto di analisi da parte di vari studiosi, che ne hanno preso in esame singoli brani o intere sezioni, allo scopo di attestare procedimenti compositivi particolari (Torrefranca) o caratteri stilistici locali, in particolare relativi alla frottola mantovana e ferrarese (Prizer). Un’accurata ricognizione sul repertorio è stata effettuata da Nanie Bridgman in un saggio degli anni Cinquanta del secolo scorso, ma non è mai stato realizzato uno studio organico sul manoscritto. Pertanto la ricerca si è proposta di riconsiderare l’intero repertorio italiano tramandato dal codice, per proporre un plausibile inquadramento stilistico nella cultura della poesia per musica coeva. La trascrizione dei testi e delle musiche, supportata dal confronto con le fonti manoscritte e a stampa, letterarie e musicali, ha consentito di formulare alcune ipotesi in merito alla circolazione del repertorio tramandato e all’ambiente di produzione del documento. L’inconsueta varietà di forme musicali riscontrate nel codice consente inoltre di assumere questo manoscritto come una delle principali fonti della tradizione musicale che precede immediatamente la ‘sistemazione’ del repertorio frottolistico effettuata da Ottaviano Petrucci, a partire dal 1504, con la pubblicazione dei suoi undici libri di frottole (1501-1514).

Entwicklung eines Screening-Instruments zu Rumination und Suppression RS-8

Rumination und Suppression sind 2 maladaptive Emotionsregulationsstrategien, die im Zusammenhang mit pathologischem Verhalten wie übermäßigem Essen oder Trinken stehen. Ein Messinstrument, welches beide Strategien in Kurzform erfasst, fehlt bisher. Der RS-8 erfasst mit 8 Items die beiden Dimensionen Rumination und Suppression. Anhand von 2 klinischen (Patienten mit Alkoholabhängigkeit [n = 79], Patienten mit Adipositas [n = 53]) und einer nichtklinischen Stichprobe (n = 133) wurde die psychometrische Qualität der Skala überprüft. Die Ergebnisse zeigen, dass der RS-8 ein valides und reliables Messinstrument ist. Die interne Konsistenz kann als gut und die faktorielle Validität als sehr gut bewertet werden. Der RS-8 ist ein ökonomisches Screening-Instrument, welches bei klinischen und nicht-klinischen Stichproben eingesetzt werden kann.

The matrix metalloproteinase inhibitor RS-130830 attenuates brain injury in experimental pneumococcal meningitis.

BACKGROUND Pneumococcal meningitis (PM) is characterized by high mortality and morbidity including long-term neurofunctional deficits. Neuropathological correlates of these sequelae are apoptosis in the hippocampal dentate gyrus and necrosis in the cortex. Matrix metalloproteinases (MMPs) play a critical role in the pathophysiology of PM. RS-130830 (Ro-1130830, CTS-1027) is a potent partially selective inhibitor of MMPs of a second generation and has been evaluated in clinical trials as an anti-arthritis drug. It inhibits MMPs involved in acute inflammation but has low activity against MMP-1 (interstitial collagenase), MMP-7 (matrilysin) and tumour necrosis factor α converting enzyme (TACE). METHODS A well-established infant rat model of PM was used where live Streptococcus pneumoniae were injected intracisternally and antibiotic treatment with ceftriaxone was initiated 18 h post infection (hpi). Treatment with RS-130830 (75 mg/kg bis in die (bid) i.p., n = 40) was started at 3 hpi while control littermates received the vehicle (succinylated gelatine, n = 42). RESULTS Cortical necrosis was significantly attenuated in animals treated with RS-130830, while the extent of hippocampal apoptosis was not influenced. At 18 hpi, concentrations of interleukin (IL)-1β and IL-10 were significantly lower in the cerebrospinal fluid of treated animals compared to controls. RS-130830 significantly reduced weight loss and leukocyte counts in the cerebrospinal fluid of survivors of PM. CONCLUSION This study identifies MMP inhibition, specifically with RS-130830, as an efficient strategy to attenuate disease severity and cortical brain injury in PM.

Ein wundrliche šine hisṭorie miṭ namin di @Zibn waizn mainśṭrs fun Rom : di noch ein mal fr lange tzaiṭ in Ṭaiṣ̌land iz gdrukṭ giwezn

[Jakob Maarssen]

Ha-zofeh le-vet Yiśraʼel : we-nispeḥu ʼelaw miktavim ʼigrot we-sirimwî Lêṭêrîs

Übers. d. Hauptsacht.: Der Beobachter des Hauses Israel

O rural depois do êxodo : As implicações do despovoamento dos campos no distrito de Arroio do Só, município de Santa Maria/RS, Brasil

This study aims to understand the sociospatial transformations resulting from the depopulation of the fields and their effects on the rural landscape of Arroio do Só in Santa Maria - RS. To this end, we attempted to identify changes in the way of life of rural people, their activities and relationships and understand how this process has occurred, its causes and its impact on quality of life and social structure of the population that remained in place. The discussion on the modernization of agriculture is key to understanding this process. This district was chosen as a research site because it is a town that, in the past, had a very big socioeconomic dynamism, and now, according to the bankruptcy of several companies and the consequent emigration of much of the population, the sociospatial dynamic has changed. It was collected data from a secondary source of FIBGE and FEE in order to periodize population dynamics of the district, county and state. The qualitative research was conducted through interviews with the subjects in the field and their representatives, with the help of the Field Diary

O rural depois do êxodo : As implicações do despovoamento dos campos no distrito de Arroio do Só, município de Santa Maria/RS, Brasil

This study aims to understand the sociospatial transformations resulting from the depopulation of the fields and their effects on the rural landscape of Arroio do Só in Santa Maria - RS. To this end, we attempted to identify changes in the way of life of rural people, their activities and relationships and understand how this process has occurred, its causes and its impact on quality of life and social structure of the population that remained in place. The discussion on the modernization of agriculture is key to understanding this process. This district was chosen as a research site because it is a town that, in the past, had a very big socioeconomic dynamism, and now, according to the bankruptcy of several companies and the consequent emigration of much of the population, the sociospatial dynamic has changed. It was collected data from a secondary source of FIBGE and FEE in order to periodize population dynamics of the district, county and state. The qualitative research was conducted through interviews with the subjects in the field and their representatives, with the help of the Field Diary