A workingman's opinion of the railroad question, the Boston & Maine monopoly a foe to New Hampshire interests : the Hazen Bill should be defeated and the Atherton Bill passed,-- a solemn warning to the legislature.

Caption title.

Catalogue of the private library of the late Mr. A.A. Smets, Savannah, Ga. : comprising one of the most valuable and extensive collections of books ever offered to the American public : containing very rare and elegant editions of early printed works, ranging from the XV. century : also, many early manuscripts and missals, with gorgeous illuminations : a large assortment of modern illustrated works, standard biographies, travels, histories, etc., etc., of the best editions : the whole to be sold by auction, at the Clinton Hall Book Salerooms and Art Galleries, Leavitt, Strebeigh & Co., auctioneers, Monday, May 25th, and following days, commencing at 4 o'clock P.M. each day.

"A southern library. A statement read before the New England historical and genealogical society ... Oct. 5, 1859" (4 p., bound at end of copy 1) relates to the present library.

A new stylometric technique for the invesigation of the true authorship of the early works of Shakespeare

DUE TO COPYRIGHT RESTRICTIONS ONLY AVAILABLE FOR CONSULTATION AT ASTON UNIVERSITY LIBRARY AND INFORMATION SERVICES WITH PRIOR ARRANGEMENT

Validation of a new easy score to predict outcome in early stage renal cell carcinoma

Background e scopi dello studio. Il carcinoma renale rappresenta circa il 3% delle neoplasie e la sua incidenza è in aumento nel mondo. Il principale approccio terapeutico alla malattia in stadio precoce è rappresentato dalla chirurgia (nefrectomia parziale o radicale), sebbene circa il 30-40% dei pazienti vada incontro a recidiva di malattia dopo tale trattamento. La probabilità di recidivare può essere stimata per mezzo di alcuni noti modelli prognostici sviluppati integrando sia parametri clinici che anatomo-patologici. Il limite principale all’impiego nella pratica clinica di questi modelli è legata alla loro complessità di calcolo che li rende di difficile fruizione. Inoltre la stratificazione prognostica dei pazienti in questo ambito ha un ruolo rilevante nella pianificazione ed interpretazione dei risultati degli studi di terapia adiuvante dopo il trattamento chirurgico del carcinoma renale in stadio iniziale. Da un' analisi non pre-pianificata condotta nell’ambito di uno studio prospettico e randomizzato multicentrico italiano di recente pubblicazione, è stato sviluppato un nuovo modello predittivo e prognostico (“score”) che utilizza quattro semplici parametri: l’età del paziente, il grading istologico, lo stadio patologico del tumore (pT) e della componente linfonodale (pN). Lo scopo del presente studio era quello di validare esternamente tale score. Pazienti e Metodi. La validazione è stata condotta su due coorti retrospettive italiane (141 e 246 pazienti) e su una prospettica americana (1943 pazienti). Lo score testato prevedeva il confronto tra due gruppi di pazienti, uno a prognosi favorevole (pazienti con almeno due parametri positivi tra i seguenti: età < 60 anni, pT1-T3a, pN0, grading 1-2) e uno a prognosi sfavorevole (pazienti con meno di due fattori positivi). La statistica descrittiva è stata utilizzata per mostrare la distribuzione dei diversi parametri. Le analisi di sopravvivenza [recurrence free survival (RFS) e overall survival (OS)] sono state eseguite il metodo di Kaplan-Meier e le comparazioni tra i vari gruppi di pazienti sono state condotte utilizzando il Mantel-Haenszel log-rank test e il modello di regressione di Cox. Il metodo di Greenwood è stato utilizzato per stimare la varianza e la costruzione degli intervalli di confidenza al 95% (95% CI), la “C-statistic” è stata utilizzata per descrivere l’ accuratezza dello score. Risultati. I risultati della validazione dello score condotta sulle due casistiche retrospettive italiane, seppur non mostrando una differenza statisticamente significativa tra i due gruppi di pazienti (gruppo favorevole versus sfavorevole), sono stati ritenuti incoraggianti e meritevoli di ulteriore validazione sulla casistica prospettica americana. Lo score ha dimostrato di performare bene sia nel determinare la prognosi in termini di RFS [hazard ratio (HR) 1.85, 95% CI 1.57-2.17, p < 0.001] che di OS [HR 2.58, 95% CI 1.98-3.35, p < 0.001]. Inoltre in questa casistica lo score ha realizzato risultati sovrapponibili a quelli dello University of California Los Angeles Integrated Staging System. Conclusioni. Questo nuovo e semplice score ha dimostrato la sua validità in altre casistiche, sia retrospettive che prospettiche, in termini di impatto prognostico su RFS e OS. Ulteriori validazioni su casistiche internazionali sono in corso per confermare i risultati qui presentati e per testare l’eventuale ruolo predittivo di questo nuovo score.

Coastal Massachusetts, Marblehead to Hampton Harbor, New Hampshire, Nautical Chart, 1776 (Image 1 of 2) (Raster Image)

This layer is a georeferenced raster image of the untitled, historic nautical chart: [A chart of the harbours of Hampton, Newbury, Ipswich, Jebeka, Squam, Cape Ann, Manchester, Beverly, Salem, Marble Head &c.] (sheet originally published in 1776). The map is [sheet 23] from the Atlantic Neptune atlas Vol. 3 : Charts of the coast and harbors of New England, from surveys taken by Samuel Holland and published by J.F.W. Des Barres, 1781. Scale [ca. 1:50,000]. This layer is image 1 of 2 total images of the two sheet source map, representing the southern portion of the map. Covers coastal Massachusetts from Ipswich Harbor to Marblehead. The image is georeferenced to the surface of the earth and fit to the 'World Mercator' (WGS 84) projected coordinate system. All map collar information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows coastal features such as harbors, inlets, rocks, channels, points, coves, shoals, islands, and more. Includes also selected land features such as cities and towns, buildings, and roads. Relief is shown by hachures; depths by soundings. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection. The entire Atlantic Neptune atlas Vol. 3 : Charts of the coast and harbors of New England has been scanned and georeferenced as part of this selection.

Coastal Massachusetts, Marblehead to Hampton Harbor, New Hampshire, Nautical Chart, 1776 (Image 2 of 2) (Raster Image)

This layer is a georeferenced raster image of the untitled, historic nautical chart: [A chart of the harbours of Hampton, Newbury, Ipswich, Jebeka, Squam, Cape Ann, Manchester, Beverly, Salem, Marble Head &c.] (sheet originally published in 1776). The map is [sheet 24] from the Atlantic Neptune atlas Vol. 3 : Charts of the coast and harbors of New England, from surveys taken by Samuel Holland and published by J.F.W. Des Barres, 1781. Scale [ca. 1:50,000]. This layer is image 2 of 2 total images of the two sheet source map, representing the northern portion of the map. Covers coastal Massachusetts and New Hampshire from Ipswich Harbor, Massachusetts to Hampton Harbor, New Hampshire. The image is georeferenced to the surface of the earth and fit to the 'World Mercator' (WGS 84) projected coordinate system. All map collar information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows coastal features such as harbors, inlets, rocks, channels, points, coves, shoals, islands, and more. Includes also selected land features such as cities and towns, buildings, and roads. Relief is shown by hachures; depths by soundings. This layer is part of a selection of digitally scanned and georeferenced historic maps from The Harvard Map Collection. The entire Atlantic Neptune atlas Vol. 3 : Charts of the coast and harbors of New England has been scanned and georeferenced as part of this selection.

Railway map of routes to the White Mountains, New Hampshire 1859 (Raster Image)

This layer is a georeferenced raster image of the historic paper map entitled: Railway map of routes to the White Mountains, by Harvey Boardman. It was published in 1859 by J.H. Bufford's Lith. Scale not given. Covers New Hampshire, Vermont, Massachusetts, Connecticut, Rhode Island, and portions of Maine, New York, and the province of Quebec, Canada. The image inside the map neatline is georeferenced to the surface of the earth and fit to the USA Contiguous Albers Equal Area Conic projection (Meters). All map collar and inset information is also available as part of the raster image, including any inset maps, profiles, statistical tables, directories, text, illustrations, or other information associated with the principal map. This map shows features such as roads, railroads, railroad stations, drainage, selected cities, towns, villages, and points of interest (hotels, houses, etc.), state boundaries, and more. Relief shown by hachures. Includes text on routes in margins. This layer is part of a selection of digitally scanned and georeferenced historic maps of New England from the Harvard Map Collection. These maps typically portray both natural and manmade features. The selection represents a range of regions, originators, ground condition dates, scales, and purposes.

New Hampshire, 1796 Raster Image

This layer is a digitized geo-referenced raster image of a 1796 map of New Hampshire drawn by D.F. Sotzmann. These Sotzmann maps (10 maps of New England and Mid-Atlantic states) typically portray both natural and manmade features. They are highly detailed with symbols for churches, roads, court houses, distilleries, iron works, mills, academies, county lines, town lines, and more. Relief is usually indicated by hachures and country boundaries have also been drawn. Place names are shown in both German and English and each map usually includes an index to land grants. Prime meridians used for this series are Greenwich and Washington, D.C.

Integrated use of surface-geophysical methods to indicate subsurface fractures at Milford, New Hampshire /

Includes bibliographical references (p. 36-38).

On the importance of an early correct education of children : embracing the mutual obligations and duties of parent and child ; and also the qualifications and discipline of teachers, with their emolument ; and a plan suggested whereby all our common schools can advantageously be made free ; the whole interspersed with several amusing, chaste anecdotes growing out of the domestic and scolastic circle ; to which is subjoined by way of appendix, the Declaration of Independence ... ; the Constitution of the United States ; with that of the state of New York as lately adopted /

Bound in green cloth; stamped in gold and blind.

Reports of cases argued and determined in the Superior Court of Judicature for the State of New-Hampshire.

Imprint varies: Concord, N.H., -1841/42.

Reports of cases argued and determined in the Supreme Judicial Court of New-Hampshire.

Vols. for 1855-59 reported by G.G. Fogg; 1859-63 by W.E. Chandler; 1863-69 by A. Hadley; 1869-74 by J. M. Shirley.

Reports of cases in the Superior Court of Judicature of New Hampshire.

Vols. for 1874/75 reported by J.M. Shirley; 1875-76 by D. Hall.