Sindicalismo e meio ambiente: a participação da Central Única dos Trabalhadores nas Conferências Eco 92 e Rio +20

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Efeitos da dose única de parecoxibe sobre a morte celular em rins de ratos submetidos à hemorragia aguda

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)

Diagnóstico e tratamento precoce da Classe III: relato de um caso clínico

In malocclusion studies, may happen not only dental discrepancies but even skeletal discrepancies. In Class III malocclusion can be observed underdeveloped maxilla, mandible protraction or both of them, and, in most of the times associated with a narrow maxilla that causes anterior or posterior crossbites, in one side or in two sides. The aim of this case report is to evaluate the facial profile and occlusal effects of interceptive orthodontics therapy. The treatment with upper arch expansion and maxilla protraction was done in an early age to be effective in the circummaxillary sutural system and to make the orthopedic effect easier. The facial mask used is positioned on two facial points and allows an anterior maxillary replacement. Patients’ compliance is important to reach treatment success, this because using the mask still in this growth and development phase is essential to make the facial and occlusal effects happen. It is important to mention that patients with Angle Class III malocclusion need to be followed till the end of their growth.

Efeitos da administração subaracnoidea em punção única, de cetamina S(+) a 5%, sem conservantes, sobre a medula espinal e as meninges de coelhos

Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

Mudanças dento-esquelétics naturais e decorrentes do tratamento ortopédico da má oclusão de Classe II

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

Otimização da síntese para obtenção de Lapdesf ibu-tau e ibu-ftd e ensaio de toxicidade pré-clínica dose única (aguda) e doses repetidas em camundongos

A inflamação é basicamente uma resposta de proteção tissular cuja função é proteger o organismo de micro-organismos e toxinas que promovem a lesão celular. A resposta inflamatória gera o aparecimento dos quatro sinais cardinais dor, edema, calor e rubor podendo posteriormente ocorrer a perda de função do tecido ou órgão. Os anti-inflamatórios não esteroides (AINEs) promovem sua atividade alterando a atividade de prostaglandinas (PGs), por inibição das isoformas de ciclo-oxigenases constitutivas (COX1) e induzidas (COX2). A inibição não seletiva destas enzimas (por AINEs clássicos) gera reações adversas graves, como as reações gastrointestinais, em pacientes pré-dispostos e/ou que as utilizam por um período prolongado. Os AINEs de segunda geração (inibidores seletivos de COX2), também se mostraram tóxicos, podendo causar alterações cardiovasculares. Neste sentido, o planejamento de novos compostos com atividade anti-inflamatória e destituídos de toxicidade ainda é um desafio para a química farmacêutica e medicinal. Dois derivados de ibuprofeno (AINE clássico) foram obtidos anteriormente no Lapdesf por Castro (2008) e Vizioli (2006), demonstrando atividade anti-inflamatória em modelo de inflamação aguda (edema de pata) e crônica (colite ulcerativa), destituídos de gastroulceração (VIZIOLI, 2009). Diante destes resultados o presente estudo visou à preparação dos compostos e o estudo pré-clínico de toxicidade em dose única (aguda) e em doses repetidas em camundongos, bem como as análises comportamentais, histopatológicas dos órgãos e ensaios bioquímicos. Os achados comportamentais, bioquímicos e histopatológicos permitem concluir que não foi observada toxicidade nos modelos estudados, exceto para o grupo de administração dose única de 2000 mg/kg via intraperitoneal do composto Lapdesf ibu-tau.

Indisciplina e sua relação com motivos, interesses e sentidos vinculados à atividade dos alunos: um estudo com uma classe de ensino médio da cidade de Medianeira-PR

Pós-graduação em Educação - FFC

Tratamiento de maloclusión classe II división 1 con el aparato de Herbst tipo férula, después del pico de crecimiento puberal

Malocclusion class II-1, is represented by a high prevalence in Brazil, being something common in orthodontic practice. One of the main characteristics of this malocclusion is jaw retrusion, by what many devices of jaw advance are presented in the literature. Being one of them Herbst's device, which is a functional and fixed device created by Emil Herbst (1905) and updated by Hans Pancherz in the decade of 80s.This device is characterized by keeping the jaw advance in a continuous way, while presenting a less active treatment, leading to an immediate aesthetic impact, and the patient cooperation is not required. To improve the anchoring and prevent the collapse of the apparatus was set up last amended version of it by Dr Raveli quoted as Herbst splint. Recent research indicates the use of this device after the peak pubertal growth, creating an appropriate response condylar. The aim of this work is to show the orthodontist a choice of how to use the splint Herbst in Class malocclusions II-1.

Tratamento da classe II hiperdivergente com o aparelho extra bucal de Thurow modificado

Objectives: natural dentofacial changes and that induced by the Thurow modified extra oral appliance (TMEOA) were evaluated in this prospective study. Methodology: the data consisted of fifteen Class II division 1 children 7 to 10 years old, with anterior open bite and hiperdivergent facial pattern treated with the Thurow appliance and of fifteen Class II division 1 children followed longitudinally from 6 to 12 years of age without treatment (Burlington Growth Centre, Toronto University, Canada). The analyses were based in traditional measurements obtained in lateral cephalometric radiographs scanned with the aid of the software Radiocef Studio®. Radiographs were taken in the beginning and after 1 year of treatment for the treated group and at the 6, 9 and 12 years of age for the control group. Results: the data analysis showed that the TMEOA significantly reduced the SNA, ANB, AOBO, SNPOc SNPM, SGO/NMe, OJ e OB. On the other hand the appliance did not interfere with the SNB e SNPP. The natural growth promoted significant change in the ANB, AOBO, SNPOc, OJ e OB from 6 to 9 years and in the SNB, SNPOc e SGo/NMe from 9 to 12 years. The restriction of the maxillary growth (SNA), reduction of the skeletal discrepancy (ANB) and the reduction of the overjet (OJ) were significant with the treatment considering the natural growth as verified in the control group. Conclusion: the TMEOA corrected the skeletal Class II malocclusion by maxillary restriction, reducing the overjet, closing the anterior open bite and decreasing both the hyper divergent facial pattern and mandible plane inclination.

Aparelho extrabucal como recurso auxiliar para alinhamento e nivelamento no tratamento orto cirúrgico de má oclusão classe III esquelética

When well indicated, the orthodontic surgical approach is the ideal treatment mean for Skeletal Class III adult patients. To improve facial esthetic results from orthognatic surgery, the leveling and alignment of maxillary dental arch must be achieved with minimal inclination and projection or even retro-inclination of anterior upper teeth. During a pre-surgical phase of 12 months, headgear bilateral force of 150 g/F was applied to the upper molars of a 22 years old male compliant patient with Class III skeletal malocclusion, to provide an upper teeth control of mesial tipping and projection during alignment and leveling. The ideal occlusal parameters required for surgical procedure were achieved without dental extractions permitting a total treatment period of 37 months. The outcomes remained stable over 3 years follow up after the removal of the appliance. The results indicate that, although headgear use depends greatly on patient compliance, when well indicated it is an interesting alternativetopromote dentaldecompensationon pre-surgical period, in order to allow surgical correction of skeletal Class III malocclusion.

Aparelho Herbst x osteotomia sagital mandibular bilateral no tratamento do padrão II, classe II, divisão 1 em adultos: relato de casos

Two treatment options are available for adult patients with skeletal Class II malocclusion caused by mandibular deficiency: combined mandibular advancement surgery and orthodontic treatment or mandibular advancement appliance. This study aimed to analyze the effects of two therapeutic modalities of Class II malocclusion treatment with mandibular deficiency. Two distinct individuals with Class II malocclusion division 1 and mandibular deficiency were treated after growth spurt. The first individual used the Herbst appliance as a therapeutic option and the second individual was treated with bilateral sagittal osteotomy. The cephalometric, occlusion and face results were evaluated for both individuals. Correction of Class II malocclusion was observed on both Herbst and surgery patients resulting on a normal occlusal relationship with normal overjet and overbite. Therefore it was concluded that Herbst appliance can be used to treat borderline skeletal Class II in adult patients.

Avaliação anteroposterior da posição da mandíbula em crianças dolicofaciais com má oclusão Classe II, divisão 1 de Angle

In this study, it is proposed to evaluate the anteroposterior position of mandible in children with Angle Class II, division 1 malocclusions, to compare two different methods of evaluating the jaw position and verifying the correlation between these two methods. We selected 26 Brazilian children with vertical growth pattern and Angle Class II, division 1 malocclusions, aged between 7 years and 8 months to 9 years and 6 months. The evaluation of the anteroposterior position of the mandible was performed with the use of lateral cephalograms by cephalometric angular SNB and linear Pog-Nperp. Based on the results obtained, it was concluded that the SNB identified more children with mandibular retrusion than Pog-Nperp; the increased tip of the SN plane may have decreased values of SNB; Pog-Nperp minimizes the possibility of error in the anteroposterior position of the mandible, since it eliminates the variable tip of the anterior skull base (SN plane); none of the cephalometric measurements used are able to eliminate the influence of the nasion point in the anterior-posterior and vertical position; correlation between SNB and Pog-Nperp is very low.

Avaliação cefalométrica das alterações do perfil facial naturais e induzidas pelos aparelhos de Herbst e Bionator no tratamento da má oclusão de classe II, divisão 1ª

The aim of this study was to evaluate the facial profile changes due to natural growth and induced by Herbst appliance and Bionator in the treatment of Class II, division 1 malocclusion. In order to do that, we used a sample of 90 lateral radiographs of 45 individuals in pre-pubertal stage, divided up in two experimental groups and one control. The first group, composed of 15 brazilian individuals, with initial mean age of 9.4 years, was treated with the Herbst appliance for a period of seven months. The second experimental group consisting of 15 brazilian individuals, initial mean age of 9.9 years has gone through bionator therapy for an average period of 21 months. The control group of 15 individuals, who were not treated orthodontically, comes up from the Burlington Growth Centre, University of Toronto, Canada. The intragroup comparison was performed using the Student t test and intergroup comparisons by ANOVA complemented by the Bonferroni test. The results have shown that only the group treated with the Herbst appliance presented significant changes in facial profile with improvement of its convexity and lower lip protrusion.