875 resultados para Chromatid breaks


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Pós-graduação em Cirurgia Veterinária - FCAV

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Manuais de literatura ensinam que o Romantismo, centrado no eu romântico em seus conflitos e anseios libertários, rompe com os códigos clássicos da poética do Arcadismo. Em Iracema: a lenda do Ceará, Alencar narra a união da índia Iracema com Martim, o colonizador português que a fascina, e dessa união nasce Moacir, fruto da primeira miscigenação de povos em terras brasileiras. A matéria-prima que Alencar ficcionalizou tem, por um lado, o componente histórico, pois personagens como o guerreiro Martim e o índio Camarão estão registradas nos anais da história; por outro lado, a construção da heroína assenta-se em figuras femininas da mitologia grega. Essa dívida com a tradição clássica, intermediada pelo poeta latino Ovídio, o próprio José de Alencar a reconhece em carta-posfácio, onde confessa ter composto “uma heroida que tem por assunto as tradições dos indígenas brasileiros e seus costumes. (ALENCAR, 1978, p.88).

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Pós-graduação em Patologia - FMB

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Pós-graduação em Ciências da Motricidade - IBRC

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)

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This paper deals with the problem of experience and its possible languages between school knowledge and practices. Its objective is to find the different possibilities of thinking the experience in the educational praxis, based on the contemporary philosophical categories of event and childhood as well as on the genres of poetic language and testimony. In order to do so, it is reconstructed a genealogy of the transformation of educational praxis into pedagogical art in its relationships with childhood whether as a government goal or as a subject, revealing the domination states that constitute them and pointing out their potential of resistance to the actual one. It is also stated that this event breaks into in the aesthetic dimension of experience and concurs in order to interrupt the order of discourse, making subjects of educational praxis think about it and causing care of oneself to become an ethic attitude put together with an aesthetics of experience. Thus, this research aims at restoring the dignity of experience among school knowledge and practices.

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From one dimension of culture, the word boundary breaks away from the idea of territorial boundary defined a priori as something fixed to the delineation of boundaries. Released this commitment, it can be thought of in other dimensions: as of transition moments of identity experienced by individuals, for women, compared to established norms. Questioning the determinant and connected speech processes of change, they left the banks in which they lived and sought recognition of self, identity and new choices have taken up other possibilities for being, social inclusion, coupled with the guarantee of their rights. Recognizing the existence of this movement, I propose a look at border on the inclusion of women as widows in order to observe the multiple identities of their female protagonists. This reflection aims to take account of social fraying beyond the limits and directions in taxes and if the widow, to expand the boundaries of its meaning and consider the possibility of hybrid subjects, differentiated, and therefore mobile and moving all the time an ongoing performance of operations, as well as contemporary studies have shown about gender relations that take into account the distinctions of race, class, ethnicity, and especially for generations.

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Pós-graduação em Estudos Literários - FCLAR

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Telomeres are the physical ends of eukaryotic linear chromosomes. Telomeres form special structures that cap chromosome ends to prevent degradation by nucleolytic attack and to distinguish chromosome termini from DNA double-strand breaks. With few exceptions, telomeres are composed primarily of repetitive DNA associated with proteins that interact specifically with double- or single-stranded telomeric DNA or with each other, forming highly ordered and dynamic complexes involved in telomere maintenance and length regulation. In proliferative cells and unicellular organisms, telomeric DNA is replicated by the actions of telomerase, a specialized reverse transcriptase. In the absence of telomerase, some cells employ a recombination-based DNA replication pathway known as alternative lengthening of telomeres. However, mammalian somatic cells that naturally lack telomerase activity show telomere shortening with increasing age leading to cell cycle arrest and senescence. In another way, mutations or deletions of telomerase components can lead to inherited genetic disorders, and the depletion of telomeric proteins can elicit the action of distinct kinases-dependent DNA damage response, culminating in chromosomal abnormalities that are incompatible with life. In addition to the intricate network formed by the interrelationships among telomeric proteins, long noncoding RNAs that arise from subtelomeric regions, named telomeric repeat-containing RNA, are also implicated in telomerase regulation and telomere maintenance. The goal for the next years is to increase our knowledge about the mechanisms that regulate telomere homeostasis and the means by which their absence or defect can elicit telomere dysfunction, which generally results in gross genomic instability and genetic diseases.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)