965 resultados para COMPUTER PROGRAMS


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Appeal Activity in the Public Assistance Programs, August 2005

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G-1 September 2005 report from the Department of Human Services

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As more tumor antigens are discovered and as computer-guided T cell epitope prediction programs become more sophisticated, many potential T cell epitopes are synthesized and demonstrated to be antigenic in vitro. However, it is estimated that about 50% of such tumor antigen-specific T cells have not been demonstrated to recognize the naturally presented epitopes due to either technical difficulties, such as T cell cloning which is still challenging for many laboratories; or the predicted T cell epitopes are not generated or not generated in sufficient amounts by the antigen processing machinery. However, to potentially identify clinically relevant vaccine candidate epitopes, it is essential to demonstrate natural antigen presentation. Here we combine the advantages of MHC tetramer and intracellular cytokine staining to sensitively detect natural antigen presentation by tumor cells for epitopes of interest. The novel method does not require T cell cloning or long-term T cell culture. Because the antigen-specific T cells are positively identified, this method is much less influenced by IFNgamma producing cells with unknown specificities and should be widely applicable.

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G-1 Appeal Activity in the Public Assistance Programs - October 2005

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G-1 - Appeal Activity in the Public Assistance - November, 2005

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This information is produced by the Department of Elder Affairs, about medicaid benifits.

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Appeal Activity in the Public Assistance Programs - December 2005

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Appeal Activity in the Public Assistance Programs, January 2006

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Appeal Activity in the Public Assistance Programs, February 2006

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The measurement of rigidity and perseveration respectively gets increasing importance in clinical psychodiagnostics. Recently we have developed a computer-assisted technique which allows to get information about inadequate persisting in psychic processes and behaviour within shortest time and to differentiate between psychopathological groups. 257 patients of both sexes who came for elucidation of their disorders to the department of clinical psychodiagnostics were investigated. The most significant differences between the groups were found in redundance of second degree (the patient has to press 10 buttons indiscriminately according to the beat of a metronom--standard condition) and in personal speed (the patient has to press 10 buttons as fast as possible--speed condition). Furthermore the psychopathological groups were ranged in the particular variables of rigidity according to their mean values and their average ranges the schizophrenics and effective psychoses were characterized by a high tendency of perseveration while the neurotics, patients with organic brain syndrome and alcohol and drug dependents showed more flexibility.

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G-1 - March 2006 - Appeal Activity in the Public Assistance Programs

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Appeal Activity in the Public Assistance Programs April 2006

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G-1, Appeal Activity in the Public Assistance Programs, May 2006