Thomas Capuanus, Ars dictaminis.

A la fin, lettre de Nicolas IV pour la Terre-Sainte (155), et lettre des évêques de Normandie à Boniface VIII pour Simon, abbé de S. Taurin d'Evreux (157v).

Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.

Hypertension is a heritable and major contributor to the global burden of disease. The sum of rare and common genetic variants robustly identified so far explain only 1%-2% of the population variation in BP and hypertension. This suggests the existence of more undiscovered common variants. We conducted a genome-wide association study in 1,621 hypertensive cases and 1,699 controls and follow-up validation analyses in 19,845 cases and 16,541 controls using an extreme case-control design. We identified a locus on chromosome 16 in the 5' region of Uromodulin (UMOD; rs13333226, combined P value of 3.6×10(-11)). The minor G allele is associated with a lower risk of hypertension (OR [95%CI]: 0.87 [0.84-0.91]), reduced urinary uromodulin excretion, better renal function; and each copy of the G allele is associated with a 7.7% reduction in risk of CVD events after adjusting for age, sex, BMI, and smoking status (H.R. = 0.923, 95% CI 0.860-0.991; p = 0.027). In a subset of 13,446 individuals with estimated glomerular filtration rate (eGFR) measurements, we show that rs13333226 is independently associated with hypertension (unadjusted for eGFR: 0.89 [0.83-0.96], p = 0.004; after eGFR adjustment: 0.89 [0.83-0.96], p = 0.003). In clinical functional studies, we also consistently show the minor G allele is associated with lower urinary uromodulin excretion. The exclusive expression of uromodulin in the thick portion of the ascending limb of Henle suggests a putative role of this variant in hypertension through an effect on sodium homeostasis. The newly discovered UMOD locus for hypertension has the potential to give new insights into the role of uromodulin in BP regulation and to identify novel drugable targets for reducing cardiovascular risk.

Les cent nouvelles nouvelles. Tome 1 / publ. d'après le seul ms. connu avec introd. et notes par M. Thomas Wright

[Cent nouvelles nouvelles (français moyen). 1857-1858]

Les cent nouvelles nouvelles. Tome 2 / publ. d'après le seul ms. connu avec introd. et notes par M. Thomas Wright

[Cent nouvelles nouvelles (français moyen). 1857-1858]

[Famille dans les années 1900] / Nadar, Eugène Atget, Henry Lartigue, photogr.

Enregistrement : 00-00-1858 - 00-00-1909

Buckle-up Baby, May 2006

Six tips on how to keep your child safe in car seats, the correct way to buckle in babies into car seats.

Buckle-up Kid, May 2006

Six tips on how to keep your toddler and children safe in car seats, the correct way to buckle in them into car seats and seats belts.