David Dublon outdoors Portraits Men

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David Dublon with his wife Paula; Dülmen, Westfahlen (Westphalia) Portraits Couples

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Markus Dublon with his wife reading newspapers on a park bench Portraits Couples

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Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38,968 women of European descent, with replication in up to 14,435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 x 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-kappaB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.

Fanny and Hugo Eichenwald with two of their three children, Fritz and Hanne outside of their home; Rheine Portraits; Family

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The three Eichenwald children, Fritz, Hanne and Hans Portraits; Family

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Portrait of Hans Eichenwald Portraits Children

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Studio portrait of unidentified soldier in military uniform; Darmstadt Portraits Men

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Adolf Lehrmann seated outdoors in the garden of the Waldorf Portraits Men

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Ernst Weill seated on a boat dock; Santa Barbara, California Portraits Men

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Portrait of Ernst Weill with his wife Erna Weill nee Helft outdoors Portraits Men

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Pianist Heida Hermanns née Goldschmidt seated at a piano; New York Portraits Women

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Portrait of pianist Heida Hermanns née Goldschmidt Portraits Women

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Isidor Simon seated at an outdoor table with his wife Friederike nee Falkenburg and two grandchildren, Helmuth and Walther Simon Portraits Family

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Portrait of Albert Einstein wearing glasses Portraits Men

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