22-10-19, congrès de l'U.V.F. [Union vélocipédique de France, debout, de gauche à droite, Alfred Riguelle, René Mathis, Van Steenbrugghe, Georges Duchesne, et assis, Louis Josset, Georges Chollet, L��on Breton, Schrader, Ernest Delamarre, Tristan Bernard, Claude Martin] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56597

22-10-19, congrès de l'U.V.F.[Union vélocipédique de France, debout, de gauche à droite, Alfred] Riguelle, [René] Mathis, Van Steenbrugghe, [Georges] Duchesne, [et assis, Louis] Josset, [Georges] Chollet, [L��on] Breton, Schrader, [Ernest] Delamarre, Tristan Bernard, [Claude] Martin : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 56598

Réponse nécessaire à la pétition des catholiques de la ville de Paris : portée à la Convention nationale le 18 novembre 1792 ([Reprod.]) / [A. J. P. Simulden]

Collection : Les archives de la Révolution française ; 8.354

Synthesis of F-18-labeled cyclic-[RGDfK] peptides for PET imaging of angiogenesis

Objectives: αvβ3 integrin is of great interest for tumor targeting because of its high concentration in tumor tissue. It recognizes ligands containing an arginine-glycine-aspartate motif (RGD), and a number of RGD-containing peptides have been developed as PET imaging probes of angiogenesis. We synthesized a series of 18F-labeled cyclic-[RGDfK] peptides for in vivo imaging of αvβ3 expression. Our F-18 labeled prosthetic groups were attached to the αvβ3 ligand via click chemistry, and the reaction conditions (time, temperature, solvent and pH) were optimized by using single modified amino acids.Methods: Seven amino acids were selected considering their different biochemical properties (polarity, total charge, presence of aromatic ring and heteroatom). All the amino acids were modified by the introduction of azido moiety to allow the interaction with alkyne prosthetic groups. Once the conditions of the click chemistry were optimized, the prosthetic groups were also coupled with the cyclic-[RGDfK] exhibiting an azido function. 4- Trimethylammonium-nitrobenzene triflate was used as precursor for the radiosynthesis of the prosthetic groups. The fluorination was carried out with K2CO3/K2.2.2 in CH3CN at 95 oC, and the nitro group was reduced with NaBH4 and Pd/C in MeOH. The resulting 18F-aniline was subsequently coupled to alkynoic acids to yield the final F-18 labeled prosthetic groups. Finally, the prosthetic groups were attached to the peptides via Huisgen's cycloaddition. Figure 1. F-18 labeled αvβ3 ligand.Results: Our new prosthetic groups were successfully clicked to the modified amino acids and to the cyclic- [RGDfK], and the reactions were almost quantitative within 1 to 3.5 h. The pH of the reaction did not influence the reaction kinetic and yield. The four steps of the F-18 labeling were completely automated providing the final products in quantities and yields practical for PET imaging. IC50 values of our ligands for αvβ3 and α5β1 demonstrated a high selectivity of our compounds towards αvβ3, as well as the negligible effect of the prosthetic groups on the affinity of the ligand to its receptor, as confirmed by the prediction of the molecular modeling.Conclusions: We have successfully synthesized novel F-18 labeled prosthetic groups, as well as novel PET imaging probes of αvβ3 expression. The reaction conditions of the Huisgen's cycloaddition were optimized with selected modified amino acids, and subsequently transposed to the cyclic-[RGDfK] peptide. IC50 data demonstrate that our 18F-labeled ligands were selective for αvβ3. In vivo microPET/CT studies in tumor bearing mice are underway.

The impact of insight in a first-episode mania with psychosis population on outcome at 18 months.

BACKGROUND: To explore whether poor initial insight during a first episode of mania with psychotic features was predictive of poor psychosocial and clinical outcomes at 18 months. METHODS: Secondary analysis was performed on data collected during an 8-week RCT comparing the efficacy of olanzapine versus chlorpromazine as an adjunct to lithium, and at 18-month follow-up. 74 participants were divided into three groups (no insight, partial insight, and full insight) according to the insight item from the Young Mania Rating Scale (YMRS). Differences between these three groups were examined at baseline and at 18 months on measures of symptoms (YMRS, HAMD-21, and CGI-S), and social and occupational functioning (SOFAS). Baseline differences between the three groups were determined using general linear models and chi-squared analyses. Group differences from baseline to 18-month follow-up were determined using repeated measures general linear models. RESULTS: At baseline there were significant differences between the three insight groups in terms of mania and functioning, but at 18 months all groups had improved significantly in terms of psychopathology, mania, depression and social and occupational functioning. There were no significant differences between the three groups at study completion with respect to these domains. LIMITATIONS: The study was limited by the lack of availability of a more detailed rating scale for insight, and it did not account for the duration of untreated psychosis (DUI). CONCLUSIONS: Poor initial insight during a first episode of mania with psychotic features does not predict poor clinical and psychosocial outcome at 18 months.

6/9/19, pose de la 1ère pierre du monument commémoratif de l'aide américaine [le président Poincaré et Maurice Damour, député des Landes, Pointe-de-Grave] : [photographie de presse] / [Agence Rol]

Référence bibliographique : Rol, 55800

Notice historique sur Joseph Decaisne : lue dans la séance publique annuelle du 18 décembre 1893 / par M. Berthelot,... ; Institut de France, Académie des Sciences

Collection : Institut ; 1893, 26 bis

Journal du marquis de Dangeau. Tome 18 / publié en entier pour la première fois par MM. Soulié, Dussieux, de Chennevières, Mantz, de Montaiglon ; avec les additions inédites du duc de Saint-Simon publiées par M. Feuillet de Conches

Comprend : Additions inédites du duc de Saint-Simon au journal du marquis de Dangeau

El programa de cooperación interuniversitària de la AECID: 18 años de historia interrumpidos por la crisis econòmica

Nota on es vol fer constar la cancel��lació del “Programa de Cooperación Interuniversitaria” conegut per l'acrònim “PCI” de l' “Agencia Española de Cooperación Internacional para el Desarrollo” (AECID), un dels programes més exitosos y de més llarga tradició de la cooperació espanyola

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ∼ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10⁻⁸), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

[1 lettre de Louis Aigoin à Antoine Banès, 18 octobre 1898]

L'informe qu'il va déposer à la bibliothèque de l'Opéra-Comique les 15 volumes reliés des principaux opéras de Boieldieu, son grand père. - Ancienne cote : Dossier d'artiste Boieldieu