Universal Biot number determining stress duration and susceptibility of ceramic cylinders to quenching

A universal Biot number, which not only describes the susceptibility of ceramic cylinders to quenching but also determines the duration that ceramic cylinders are subjected to thermal stress during thermal shock, is theoretically obtained. The analysis proves that thermal shock failure of ceramic cylinders with a Biot number greater than the critical value is a rapid process, which only occurs in the initial heat conduction regime. The results provide a guide to the selection of ceramic materials for thermostructural engineering, with particular reference to thermal shock.

A Simple, Universal Colorimetric Assay for Endonuclease/Methyltransferase Activity and Inhibition Based on an Enzyme-Responsive Nanoparticle System

An enzyme responsive nanoparticle system that uses a DNA-gold nanoparticle (AuNP) assembly as the substrate has been developed for the simple, sensitive, and universal monitoring of restriction endonucleases in real time. This new assay takes advantage of the palindromic recognition sequence of the restriction nucleases and the unique optical properties of AuNPs and is simpler than the procedure previously described by by Xu et al. (Angew. Chem. Int. Ed. Engl. 2007, 46, 3468-3470). Because it involves only one type of ssDNA modified AuNPs, this assay can be directed toward most of the endonucleases by simply changing the recognition sequence found within the linker DNA. In addition, the endonuclease activity could be quantitatively analyzed by the value of the reciprocal of hydrolysis half time (t(1/2)(-1). Furthermore, our new design could also be applied to the assay of methyltransferase activity since the methylation of DNA inhibits its cleavage by the corresponding restriction endonuclease, and thus, this new methodology can be easily adapted to high-throughput screening of methyltransferase inhibitors.

基于XML/Web Services的月球探测数据管理与集成技术研究

随着网络技术、特别是Internet技术的发展，分布式系统的高睦能、高可靠性、高灵敏度、可扩展性和系统透明性使得基于分布式系统的应用越来越广泛。在分布式坏境下，信息系统的集成是必须认真考虑的问题。研究如何集成和统一访问分布的、异构的数据资源，实现各种数据的转换、交流与共享；以及如何建立一个开放、可扩展和异构兼容的新一代信息管理系统成为当今网络应用的重要研究方向。本文针对建立月球探测数据管理和集成系统的数据集成与操作集成两方面的内容，重点分析和研究了数据存储管理和系统集成技术，结合月球探测数据管理的应用集成需求与特点提出了基于XML技术的数据存储与管理和基于Web Service技术的系统集成方案。并利用XML／WebService技术基于Net平台开发了一个月球探测数据管理与集成系统实例。研究内容主要包括以下四个方面： （1）基于XML的数据模型与数据库存储。利用XML的自描述性、独立于平台和应用、半结构化，机器可处理、可扩展性以及便于网络传输和广泛支持的特性，实现了基于关系数据库的XML数据存储。对系统中的结构化和非结构化数据信息、都进行了XML标记定义，实现了信息存储和查询的小粒度，增强了数据的表示、查询、插入和删除等数据处理能力和效率。同时，利用XML作为月球探测数据交换和信息传输的格式，也为实现与异构系统数据的互操作提供了理想的角军决方案。（2）基于WebServices的分布式信息系统集成的体系结构。在对XML、SOAP、WSDL和UDDI关键技术和标准规范进行研究与探讨基础上，针对绕月探测数据管理的需求提出了基于XML／Web Service的三层分布式结构模型。分别是表示层、应用逻辑层、服务端数据层。实现了系统功能的可迁移性和可装配性、各层间传输过程中数据流的XML化、接口定义的动态性。与传统技术开发的耦合的分布式应用系统相比，系统在跨平台性、可配置性、可伸缩性、可维护性等方面都有了大幅度的提高。（3）基于，NET平台系统的开发与实现。深入分析和研究了Mic1’osoft．NET平台的核心技术与整体技术框架，在VisLla1Sttldio．NET开发环境中利用C＃、ASP．NET、ADO．NET基于关系型数据库Oracle9i开发实现了统一身份认证系统和月球探测数据管理与集成系统。统一身份认证系统是一个通用的统一用户身份认证管理系统，包括用户管理、身份验证、实体管理、日志监控和消息、管理等功能，达到了一次登录，所有系统共用的目的。月球探测数据管理与集成系统包括数据管理、信息发布、系统管理、综合查询和应用集成五大功能模块，相对于原来的紧祸合的应用系统而言，系统的开发效率、重用性、祸合度、灵活性和自适 应性都有了很大的提高。（4）基于XML／WebServices的动态系统集成。分析了传统分布式对象模型在异构环境集成的弊端，基于XML、SOAP和WSDL等技术规范基础上，实现了统一身份认证系统、月球探测数据管理与集成系统、小空间碎片数据库系统以及其它语言开发的应用系统的信息集成、实现了资源时空的有效整合。通过这些集成应用实例，充分体现和说明了Web Services技术在应用系统集成方面的优越性。本研究的成果，也将为地球化学研究领域涉及海量数据的处理、管理和系统集成提供示范实例，推动地球化学数据的融合和综合应用。

Implementing Universal Computation in an Evolutionary System

Evolutionary algorithms are a common tool in engineering and in the study of natural evolution. Here we take their use in a new direction by showing how they can be made to implement a universal computer. We consider populations of individuals with genes whose values are the variables of interest. By allowing them to interact with one another in a specified environment with limited resources, we demonstrate the ability to construct any arbitrary logic circuit. We explore models based on the limits of small and large populations, and show examples of such a system in action, implementing a simple logic circuit.

Vulnerabilidade dos solos à erosão: estimativa da perda de solos na bacia hidrográfica do Rio Guapi-Macacu - RJ.

Este trabalho apresenta metodologias para estimativa de perda de solos na Bacia Hidrográfica do Rio Guapi-Macacu - RJ. Para a estimativa anual de perdas de solo foi utilizada a ferramenta InVest (Integrated Valuation of Environmental Services and Tradeoffs) através do módulo que desenvolve retenção de sedimentos. Esse módulo permite calcular a perda de solo média anual de cada parcela de terra, além de determinar o quanto de solo pode chegar a um determinado ponto de interesse. Para identificar a perda potencial de solo, o modelo emprega a Equação Universal de Perda de Solo (USLE) na escala do pixel, integrando informações sobre relevo, precipitação, padrões de uso da terra e propriedades do solo. Seus resultados são dados em toneladas por sub-bacias. Os resultados obtidos neste trabalho permitiram concluir que embora haja limitações no uso da Equação Universal de Perda de Solo, o modelo possibilitou a espacialização de classes de perdas de solos com indicações de áreas consideradas mais ou menos vulneráveis aos processos erosivos, considerando os dados disponíveis e suas escalas. O uso do InVest para calcular a USLE apresentou como principal vantagem a possibilidade de integração dos dados necessários em um único ambiente, reduzindo a possibilidade de erros na conversão de dados. Contudo, a maior limitação encontrada a sua aplicação está na dificuldade de obtenção de dados de entrada necessários ao modelo.

Supporting the case for “progressive universalism” in health visiting: Scottish mothers and health visitors’ perspectives on targeting and rationing health visiting services, with a focus on the Lothian Child Concern Model.

Aims. To explore parents and professionals’ experience of family assessment in health visiting (public health nursing), with a focus on the Lothian Child Concern Model (LCCM). Background. Health visitors (HVs) currently assess families as requiring core, additional or intensive support, and offer support at a corresponding level. The majority of families are assessed as core and receive no pro-active support beyond the early days. Previous assessment tools, consisting of checklists, have been criticised as being ineffective in identifying a range of health needs and unacceptable to parents and HVs. The LCCM model was developed and introduced in the study area to promote a partnership approach with parents and assess strengths as well as difficulties in parents’ capacity to care for their child. Methods. Qualitative methods were used. Ten mothers and twelve HVs took part in individual semi-structured interviews. Results. Most mothers were aware of the assessment process but some felt that they were not involved in the decision making process. Explaining the assessment process to parents is problematic and not all HVs do so. The assessment process was stressful for some mothers. HVs find the model useful for structuring and documenting the assessment process. Many believe that most families benefit from some support, using public health approaches. Families are often assessed as core because there are insufficient resources to support all those who meet the criteria of the additional category, and managers assess caseloads in terms of families with child protection concerns. Conclusions. The study findings support the concept of “progressive universalism” which provides a continuum of intensity of support to families, depending on need. Mothers would like better partnership working with HVs. Relevance to clinical practice. The study endorses proposed policy changes to re-establish the public health role of HVs and to lower the threshold for families to qualify for support.

The impact of interconnectedness in a triadic relationship between a financial services provider, IFAs, and customers.

The aim of this study is to investigate the impact of interconnectedness between a long-term savings and investments provider, Independent Financial Advisers (IFAs) and customers. Ritter’s (2000) framework of the effect of interconnectedness was used to analyse this triadic relationship. Conceptual studies of triadic business relationships are scarce in marketing and organisational research (Blakenburg & Johanson, 1992; Havila, Johnson & Thilenius, 2004; Ritter, 2000). However, the applicability of a triadic relationship has been tested in a number of case studies (Andersson & Mattsson, 2004; Cunningham & Pyatt, 1989; Jaaskelainen, Kuivalainen & Saarenketo, 2000; Narayandas, 2002; Odorici & Corrado, 2004; Pardo & Salle, 1994; Trimachi, 2002). This study was conducted in collaboration with one of the UK’s largest long-term savings and investments providers. A substantial proportion of the provider’s business is conducted through IFAs and thus their significance as a major stakeholder. Indeed, the majority of sales in the long-term savings and investments industry in the UK are realised through IFAs. Academic studies (Gough, 2005; Gough & Nurullah, 2009) have indicated that IFAs are the strongest distribution channel in the industry. Thus, by analysing the impact of the interconnectedness in this relationship, a strategy that can increase the relationship performance can be proposed. However, to the best of the authors’ knowledge, a study that investigates the effect of the interconnectedness in this triadic relationship has not been established. In addition, the regulatory environment which continues to face change such as the recent implementation of Retail Distribution Review (RDR) on 1st January 2013 will make the relationship more rather than less complex.

Uptake and use of electronic information services: trends in UK higher education from the JUSTEIS project

Urquhart, C., Lonsdale, R.,Thomas, R., Spink, S., Yeoman, A., Armstrong, C. & Fenton, R. (2003). Uptake and use of electronic information services: trends in UK higher education from the JUSTEIS project. Program, 37(3), 167-180. Sponsorship: JISC

Student use of electronic information services in further education

Urquhart,C., Thomas, R., Spink, S., Fenton, R., Yeoman, A., Lonsdale, R., Armstrong, C., Banwell, L., Ray, K., Coulson, G. & Rowley, J. (2005). Student use of electronic information services in further education. International Journal of Information Management, 25(4), 347-362. Sponsorship: JISC

JUSTEIS: JISC Usage Surveys: Trends in Electronic Information Services Final report 2003/2004 Cycle Five

Urquhart, C., Spink, S., Thomas, R., Yeoman, A., Durbin, J., Turner, J., Fenton, R. & Armstrong, C. (2004). JUSTEIS: JISC Usage Surveys: Trends in Electronic Information Services Final report 2003/2004 Cycle Five. Aberystwyth: Department of Information Studies, University of Wales Aberystwyth. Sponsorship: JISC

The management of health library outreach services: evaluation and reflection on lessons learned on the VIVOS project

Yeoman, A. J., Cooper, J. M., Urquhart, C. J. & Tyler, A. (2003). The management of health library outreach services: evaluation and reflection on lessons learned on the VIVOS project. Journal of the Medical Library Association, 91(4), 426-433. Sponsorship: Resource