Reconstructing the evolutionary history of China: A caveat about inferences drawn from ancient DNA

The decipherment of the meager information provided by short fragments of ancient mitochondrial DNA (mtDNA) is notoriously difficult but is regarded as a most promising way toward reconstructing the past from the genetic perspective. By haplogroup-specific hypervariable segment (HVS) motif search and matching or near-matching with available modem data sets, most of the ancient mtDNAs can be tentatively assigned to haplogroups, which are often subcontinent specific. Further typing for mtDNA haplogroup-diagnostic coding region polymorphisms, however, is indispensable for establishing the geographic/genetic affinities of ancient samples with less ambiguity. In the present study, we sequenced a fragment (similar to 982 bp) of the mtDNA control region in 76 Han individuals from Taian, Shandong, China, and we combined these data with previously reported samples from Zibo and Qingdao, Shandong. The reanalysis of two previously published ancient mtDNA population data sets from Linzi (same province) then indicates that the ancient populations had features in common with the modem populations from south China rather than any specific affinity to the European mtDNA pool. Our results highlight that ancient mtDNA data obtained under different sampling schemes and subject to potential contamination can easily create the impression of drastic spatiotemporal changes in the genetic structure of a regional population during the past few thousand years if inappropriate methods of data analysis are employed.

Single trial learning of external dynamics: What can the brain teach us about learning mechanisms?

Humans have exceptional abilities to learn new skills, manipulate tools and objects, and interact with our environment. In order to be successful at these tasks, our brain has developed learning mechanisms to deal with and compensate for the constantly changing dynamics of the world. If this mechanism or mechanisms can be understood from a computational point of view, then they can also be used to drive the adaptability and learning of robots. In this paper, we will present a new technique for examining changes in the feedforward motor command due to adaptation. This technique can then be utilized for examining motor adaptation in humans and determining a computational algorithm which explains motor learning. © 2007.

What you should know about carp: its origin, varieties, physical appearance, feeding habits

The article discusses the different varieties of carp, their origin, physical appearance and feeding habits. The species discussed are grass carp (Ctenopharyngodon idella), silver carp (Hypophthalmichthys molitrix), bighead carp (Aristichthys nobilis), catla (Catla catla), rohu (Labeo rohita), mrigal (Cirrhinus mrigala), and common carp (Cyprinus carpio).

Design advisor: How to supply designers with knowledge about inclusion

Chapter 15 Design Advisor: How to Supply Designers with Knowledge about Inclusion? E. Zitkus, PM Langdon and PJ Clarkson 15.1 Introduction In an ideal scenario accessibility issues such as legibility, usability and associated cognitive ...

Confidence in beliefs about pain predicts expectancy effects on pain perception and anticipatory processing in right anterior insula.

Psychological factors play a major role in exacerbating chronic pain. Effective self-management of pain is often hindered by inaccurate beliefs about the nature of pain which lead to a high degree of emotional reactivity. Probabilistic models of perception state that greater confidence (certainty) in beliefs increases their influence on perception and behavior. In this study, we treat confidence as a metacognitive process dissociable from the content of belief. We hypothesized that confidence is associated with anticipatory activation of areas of the pain matrix involved with top-down modulation of pain. Healthy volunteers rated their beliefs about the emotional distress that experimental pain would cause, and separately rated their level of confidence in this belief. Confidence predicted the influence of anticipation cues on experienced pain. We measured brain activity during anticipation of pain using high-density EEG and used electromagnetic tomography to determine neural substrates of this effect. Confidence correlated with activity in right anterior insula, posterior midcingulate and inferior parietal cortices during the anticipation of pain. Activity in the right anterior insula predicted a greater influence of anticipation cues on pain perception, whereas activity in right inferior parietal cortex predicted a decreased influence of anticipatory cues. The results support probabilistic models of pain perception and suggest that confidence in beliefs is an important determinant of expectancy effects on pain perception.

Some remarks about periodic feedback stabilization

Periodic feedback stabilization is a very natural solution to overcome the topological obstructions which may occur when one tries to asymptotically (locally) stabilize a (locally) controllable nonlinear system around an equilibrium point. The object of this paper is to give a simple geometric interpretation of this fact, to show that one obtains a weakened form of those obstructions when periodic feedback is used, and to illustrate the success of periodic feedback stabilization on a representative system which contains a drift.

Decisions about decisions.

A major puzzle of decision making is how the brain decides which decision system to use at any one time. In this issue of Neuron, Lee et al. (2014) provide a theoretical, behavioral, and neurobiological account of a prefrontal reliability-based arbitration system.