Goal sketching with activity diagrams

Goal orientation is acknowledged as an important paradigm in requirements engineering. The structure of a goal-responsibility model provides opportunities for appraising the intention of a development. Creating a suitable model under agile constraints (time, incompleteness and catching up after an initial burst of creativity) can be challenging. Here we propose a marriage of UML activity diagrams with goal sketching in order to facilitate the production of goal responsibility models under these constraints.

A lightweight technique for assessing risks in requirements analysis

A simple and practical technique for assessing the risks, that is, the potential for error, and consequent loss, in software system development, acquired during a requirements engineering phase is described. The technique uses a goal-based requirements analysis as a framework to identify and rate a set of key issues in order to arrive at estimates of the feasibility and adequacy of the requirements. The technique is illustrated and how it has been applied to a real systems development project is shown. How problems in this project could have been identified earlier is shown, thereby avoiding costly additional work and unhappy users.

Statistical inferences in phylogeography

In conventional phylogeographic studies, historical demographic processes are elucidated from the geographical distribution of individuals represented on an inferred gene tree. However, the interpretation of gene trees in this context can be difficult as the same demographic/geographical process can randomly lead to multiple different genealogies. Likewise, the same gene trees can arise under different demographic models. This problem has led to the emergence of many statistical methods for making phylogeographic inferences. A popular phylogeographic approach based on nested clade analysis is challenged by the fact that a certain amount of the interpretation of the data is left to the subjective choices of the user, and it has been argued that the method performs poorly in simulation studies. More rigorous statistical methods based on coalescence theory have been developed. However, these methods may also be challenged by computational problems or poor model choice. In this review, we will describe the development of statistical methods in phylogeographic analysis, and discuss some of the challenges facing these methods.

A lightweight technique for assessing risks in requirements analysis

A simple and practical technique for assessing the risks, that is, the potential for error, and consequent loss, in software system development, acquired during a requirements engineering phase is described. The technique uses a goal-based requirements analysis as a framework to identify and rate a set of key issues in order to arrive at estimates of the feasibility and adequacy of the requirements. The technique is illustrated and how it has been applied to a real systems development project is shown. How problems in this project could have been identified earlier is shown, thereby avoiding costly additional work and unhappy users.

RE1 silencing transcription factor/neuron-restrictive silencing factor regulates expansion of adult mouse subventricular zone-derived neural stem/progenitor cells in vitro

Adult neural stem cell (aNSC) activity is tuned by external stimuli through the recruitment of transcription factors. This study examines the RE1 silencing transcription factor (REST) in neural stem/progenitor cells isolated from the subventricular zone of adult mouse brain and provides the first extensive characterization of REST-mediated control of the cellular and molecular properties. This study shows that REST knockdown affects the capacity of progenitor cells to generate neurospheres, reduces cell proliferation, and triggers cell differentiation despite the presence of growth factors. Genome- and transcriptome-wide analyses show that REST binding sites are significantly enriched in genes associated with synaptic transmission and nervous system development and function. Seeking candidate regulators of aNSC function, this study identifies a member of the bone morphogenetic protein (BMP) family, BMP6, the mRNA and protein of which increased after REST knockdown. The results of this study extend previous findings, demonstrating a reciprocal control of REST expression by BMPs. Administration of exogenous BMP6 inhibits aNSC proliferation and induces the expression of the astrocytic marker glial fibrillary acidic protein, highlighting its antimitogenic and prodifferentiative effects. This study suggests that BMP6 produced in a REST-regulated manner together with other signals can contribute to regulation of NSC maintenance and fate. © 2015 Wiley Periodicals, Inc.

Upregulation of E2F1 in cerebellar neuroprogenitor cells and cell cycle arrest during postnatal brain development

In the developing cerebellum, proliferation of granular neuroprogenitor (GNP) cells lasts until the early postnatal stages when terminal maturation of the cerebellar cortex occurs. GNPs are considered cell targets for neoplastic transformation, and disturbances in cerebellar GNP cell proliferation may contribute to the development of pediatric medulloblastoma. At the molecular level, proliferation of GNPs is regulated through an orchestrated action of the SHH, NOTCH, and WNT pathways, but the underlying mechanisms still need to be dissected. Here, we report that expression of the E2F1 transcription factor in rat GNPs is inversely correlated with cell proliferation rate during postnatal development, as opposed to its traditional SHH-dependent induction of cell cycle. Proliferation of GNPs peaked at postnatal day 3 (P3), with a subsequent continuing decrease in proliferation rates occurring until P12. Such gradual decline in proliferating neuroprogenitors paralleled the extent of cerebellum maturation confirmed by histological analysis with cresyl violet staining and temporal expression profiling of SHH, NOTCH2, and WNT4 genes. A time course analysis of E2F1 expression in GNPs revealed significantly increased levels at P12, correlating with decreased cell proliferation. Expression of the cell cycle inhibitor p18 (Ink4c) , a target of E2F1, was also significantly higher at P12. Conversely, increased E2F1 expression did not correlate with either SMAC/DIABLO and BCL2 expression profiles or apoptosis of cerebellar cells. Altogether, these results suggest that E2F1 may also be involved in the inhibition of GNP proliferation during rat postnatal development despite its conventional mitogenic effects.

Connexin-mediated communication controls cell proliferation and is essential in retinal histogenesis

Connexin (Cx) channels and hemichannels are involved in essential processes during nervous system development such as apoptosis, propagation of spontaneous activity and interkinetic nuclear movement. In the first part of this study, we extensively characterized Cx gene and protein expression during retinal histogenesis. We observed distinct spatio-temporal patterns among Studied Cx and an overriding, ubiquitous presence of Cx45 in progenitor cells. The role of Cx-mediated communication was assessed by using broad-spectrum (carbenoxotone, CBX) and Cx36/Cx50 channel-specific (quinine) blockers. In vivo application of CBX, but not quinine, caused remarkable reduction in retinal thickness, suggesting changes in cell proliferation/apoptosis ratio. Indeed, we observed a decreased number of mitotic cells in CBX-injected retinas, with no significant changes in the expression of PCNA, a marker for cells in proliferative state. Taken together, Our results pointed a pivotal role of Cx45 in the developing retina. Moreover, this study revealed that Cx-mediated Communication is essential in retinal histogenesis, particularly in the control of cell proliferation. (C) 2009 ISDN. Published by Elsevier Ltd. All rights reserved.

Enhanced Neural Progenitor/Stem Cells Self-Renewal via the Interaction of Stress-Inducible Protein 1 with the Prion Protein

Prion protein (PrPC), when associated with the secreted form of the stress-inducible protein 1 (STI1), plays an important role in neural survival, neuritogenesis, and memory formation. However, the role of the PrP(C)-STI1 complex in the physiology of neural progenitor/stem cells is unknown. In this article, we observed that neurospheres cultured from fetal forebrain of wild-type (Prnp(+/+)) and PrP(C)-null (Prnp(0/0)) mice were maintained for several passages without the loss of self-renewal or multipotentiality, as assessed by their continued capacity to generate neurons, astrocytes, and oligodendrocytes. The homogeneous expression and colocalization of STI1 and PrP(C) suggest that they may associate and function as a complex in neurosphere-derived stem cells. The formation of neurospheres from Prnp(0/0) mice was reduced significantly when compared with their wild-type counterparts. In addition, blockade of secreted STI1, and its cell surface ligand, PrP(C), with specific antibodies, impaired Prnp(+/+) neurosphere formation without further impairing the formation of Prnp(0/0) neurospheres. Alternatively, neurosphere formation was enhanced by recombinant STI1 application in cells expressing PrP(C) but not in cells from Prnp(0/0) mice. The STI1-PrP(C) interaction was able to stimulate cell proliferation in the neurosphere-forming assay, while no effect on cell survival or the expression of neural markers was observed. These data suggest that the STI1-PrP(C) complex may play a critical role in neural progenitor/stem cells self-renewal via the modulation of cell proliferation, leading to the control of the stemness capacity of these cells during nervous system development. STEM CELLS 2011;29:1126-1136

En analys av testprocesser med TMap som testmetod

Today there are many system development projects that break both budget and time plan. Often this depends on defects in the information systems that could have been prevented. The cost of test can in some cases be as high as 50 % of the projects total cost and it's at the same time an important part of development. Test as such has moved its focus from the software it self and its faults to a wider perspective on whole infrastructures of information systems where assure a good quality is important. Sogeti in the Netherlands have developed a test method called TMap (Test Management approach) that can be used for structured testing of information systems. TMap haven't been used as much as desired in the office in Borlänge. Because Microsoft is releasing a new version of their platform Visual Studio Team System (VSTS 2010) some colleges at Sogeti in the Netherlands are about to develop a template that can support the use of TMap in VSTS 2010. When we write this the template is still in development. The goal for Sogeti was to find out the differences between the test functionality in VSTS 2008 and 2010. By using the purpose with this essay, which was to analyze the test process in VSTS 2008 with TMap against the test process in VSTS 2010 together with the template we got much help to achieve the goal. The analysis was done with four different aspects: The TPI and TMMi models, problem and strength analyses and a few question formulations. The TPI and TMMi models where used to analyses and evaluate the test process. The analysis showed that there were differences between the both test processes. VSTS 2010 together with the template gave a better support to use TMap and perform test. In VSTS 2010 the test tool Camano is connected to TFS and the tool is also to make the execution and logging of tests easier. This leads to a test process that is easier to handle and has a better support for TMap.

En beskrivning av manuellt test : Svagheter och styrkor med och utan stöd avett testverktyg

Test is an area in system development. Test can be performed manually or automated. Test activities can be supported by Word documents and Excel sheets for documenting and executing test cases and as well for follow up, but there are also new test tools designed to support and facilitate the testing process and the activities of the test. This study has described manual test and identified strengths and weaknesses of manual testing with a testing tool called Microsoft Test Manager (MTM) and of manual testing using test cases and test log templates developed by the testers at Sogeti. The result that emerged from the problem and strength analysis and the analysis of literature studies and firsthand experiences (in terms of creating, documenting and executing test cases) addresses the issue of the following weaknesses and strengths. Strengths of the test tool is that it contains needed functionality all in one place and it is available when needed without having to open up other programs which saves many steps of activity. Strengths with test without the support of test tools is mainly that it is easy to learn and gives a good overview, easy to format text as desired and flexible to changes during execution of a test case. Weaknesses in test with the support of test tools include that it is difficult to get a good overview of the entire test case, that it is not possible to format the text in the test steps. It is as well not possible to modify the test steps during execution. It is also difficult to use some of the test design techniques of TMap, for example a checklist, when using the test tool MTM. Weaknesses with test without the support of the testing tool MTM is that the tester gets many more steps of activities to do compared to doing the same activities with the support of the testing tool MTM. There is more to remember because the documents the tester use are not directly linked. Altogether the strengths of the test tool stands out when it comes to supporting the testing process.

Upplevda problem med projektstyrningsmetoden Scrum i systemutvecklingsprojekt : En studie av Scrums-relaterade problem hos IT- företag i Borlängeregion

Många projekt misslyckas och en av anledningarna är dålig styrning av projektet i allmänhet och inom IT branschen i synnerhet. Baserad på kritik av de traditionella metoderna under de senaste åren, så har det uppkommit flera lättrörliga metoder som kallas Agila metoder. Scrum är den mest kända Agila metoden som används idag. Metoden lovar goda resultat, men i en artikel ur tidningen Computer Sweden (feb 2009) står det ”siffror visar att nio av tio Scrumprojekt misslyckas”. Artikeln triggade vårt intresse av att ta reda på vilka problem specifika för Scrum som många har kritiserat och valde därför att rikta in vår studie mot detta. Uppsatsen syftar till att undersöka om lokala IT-företag i Borlänge, Headlight, Sogeti ochstatliga nätkapacitetleverantören Trafikverket ICT lider av det allmänna problem som de andra Scrumanvändarna upplever i samband med användningen av metoden. Denna uppsats har fokus på fyra problemområden: bristfällig dokumentation, sämre effektivitet i arbetsprocessen, sämre effektivitet i arbetsprocessen i stora projekt samt bristande stöd för utvärdering. För vår studie har litteraturstudier och intervjuer genomförts. Intervjuserier gjordes på elva personer hos våra fallföretag. Målgruppen för våra intervjuer är Product Owner (PO) ScrumMaster (SM) och utvecklare. Vi kan efter genomförd studie dra slutsatsen att de allmänna upplevda problem som de andra Scrumanvändaren upplever har vi även kunnat identifiera hos våra fallföretag. Resultaten har bekräftats med insamlade data och vår teoretiska ram. I diskussionen presenterar vi rekommendationer för att undvik relaterade problem med Scrum.

Mått för att mäta kodkvalitet undersystemutvecklingsprocessen

Viljan att hålla en hög kvalitet på den kod som skrivs vid utveckling av system och applikationerär inte något nytt i utvecklingsvärlden. Flera större företag använder sig av olika mått för attmäta kvaliteten på koden i sina system med målet att hålla en hög driftsäkerhet.Trafikverket är en statlig myndighet som ansvarar för driften av bland annat de system somhåller igång Sveriges järnvägsnät. Eftersom systemen fyller en viktig del i att säkra driften ochse till att tågpositioner, planering av avgångar och hantering av driftstörningar fungerar dygnetrunt för hela landet anser de att det är viktigt att sträva efter att hålla en hög kvalitet påsystemen.Syftet med det här examensarbetet var att ta reda på vilka mått som kan vara möjliga attanvända under systemutvecklingsprocessen för att mäta kvaliteten på kod och hur måtten kananvändas för att öka kvaliteten på IT-lösningar. Detta för att redan på ett tidigt stadie kunnamäta kvaliteten på den kod som skrivs i både befintliga och nyutvecklade system.Studien är en fallstudie som utfördes på Trafikverket, de olika måtten som undersöktes varcode coverage, nivån på maintainability index och antalet inrapporterade incidenter för varjesystem. Mätningar utfördes på sju av Trafikverkets system som i analysen jämfördes motantalet rapporterade incidenter. Intervjuer utfördes för att ge en bild över hur arbetssättet vidutveckling kan påverka kvaliteten. Genom litteraturstudier kom det fram ett mått som inte kundeanvändas praktiskt i det här fallet men är högst intressant, detta är cyclomatic complexity somfinns som en del av maintainability index men som även separat påverkar möjligheten att skrivaenhetstest.Resultaten av studien visar att måtten är användbara för ändamålet men bör inte användassom enskilda mått för att mäta kvalitet eftersom de fyller olika funktioner. Det är viktigt attarbetssättet runt utveckling genomförs enligt en tydlig struktur och att utvecklarna både harkunskap om hur man arbetar med enhetstest och följer kodprinciper för strukturen. Tydligakopplingar mellan nivån på code coverage och inflödet av incidenter kunde ses i de undersöktasystemen där hög code coverage ger ett lägre inflöde av incidenter. Ingen korrelation mellanmaintainability index och incidenter kunde hittas.

Fábricas de software e a academia: análise da formação acadêmica em informática no município do Rio de Janeiro

As Brazil wants to be perceived as a competitor in providing computer applications and system development services in the global market, the concept of Software Factory gains importance. The metaphor for the 'Factory', when applied to the activity of software development, is used to describe organizations which produce software with a minimum quality standard and at competitive costs. However, the term 'Factory' recalls Fordist concepts, which have been challenged for a few decades in the manufacturing industry. This study analyzed university curricula and how students and teachers perceive the concept of Software Factory and assessed them in relation to the Fordism ------------ post-Fordism /continuum/. It was observed that some of the teachers who have influence over curricula define Software Factories according to Fordist concepts. It was also observed that, despite opportunities for improvements, curricula are adequately structured with regards to the skills a professional at these organizations must possess. We conclude that education provided at the programs being analyzed is adequate, but that it must be supplemented by companies or by the professionals themselves so that the knowledge acquired in the programs may be put in practice.

Responsabilidade social empresarial: o caso Deloitte

Recentemente, a questão da Responsabilidade Social Empresarial tem se apresentado perante a sociedade como um assunto significativamente relevante, polêmico e dinâmico. Embora estudos mostrem que empresas têm abordado este tema através de uma gestão formal das ações socialmente responsáveis junto aos seus públicos envolvidos, deve-se destacar que poucas empresas implementam esta prática em seus negócios por desconhecerem seus resultados. Este trabalho visa contribuir para o preenchimento desta lacuna, analisando práticas e conceitos vinculados a este tema. O estudo busca, então, avaliar o grau de Responsabilidade Social Interna numa organização, partindo da experiência da empresa de auditoria e consultoria Deloitte Touche Tohmatsu, com foco em sua área de Consultoria Empresarial do escritório do Rio de Janeiro. Tomou-se como base teórica, conceitos sobre autogestão e organização comunitária, responsabilidades e papel social da organização, desenvolvimento sustentável e a responsabilidade social da empresa. O trabalho apresenta uma pesquisa de abordagem qualitativa e, com relação aos meios, bibliográfica e de campo. A pesquisa foi aplicada junto a 41 consultores, dos quais 37 responderam ao questionário previamente elaborado. Como resultado, a investigação aponta para confirmação das suposições levantadas, ou seja, a Responsabilidade Social Empresarial pode ser utilizada como uma forma de gestão capaz de focar os seus negócios no desenvolvimento sustentável, no relacionamento transparente com os públicos envolvidos e no compromisso com a sociedade.

A gestão de custos e o desenvolvimento empresarial : um estudo de caso na RGB Indústria Metalúrgica Ltda

A presente dissertação desenvolve uma análise sobre a gestão de custos e a utilização das informações para fins gerenciais, discutindo sua importância e potencialidades para o desenvolvimento empresarial. O trabalho faz uma revisão conceitual a respeito da gestão de custos e sua importância como insumo essencial para a atividade gerencial, contemplando o ambiente competitivo da indústria brasileira e expõe visões a respeito do papel e da importância da gestão de custos enquanto instrumento de gerenciamento e administração. Também sugere que devem ser mais exploradas pela gestão de custos as possibilidades de fornecimento de informações final ao tomador de decisões. A importância das informações de custos para fins gerenciais é ilustrada através do modelo de gerenciamento dos custos como fator decisivo para o desenvolvimento empresarial. Constatou-se que a implantação e a disponibilidade de informações oriundas da gestão de custos foram determinantes para o desenvolvimento da RGB Indústria Metalúrgica Ltda. Concluiu-se que as informações da gestão de custos são elementos imprescindíveis para viabilizar o processo de desenvolvimento empresarial.