Determinação de genes mórbidos e drogáveis a partir da construção e análise da rede integrada de interações moleculares entre genes humanos

The discovering process of new morbid genes and new target proteins for drugs have been shown to be very costly and laborious. Having in view cutting costs and speeding up this process, we propose, in this work, a new method to determine the gene druggability score and morbidity score, the probabilities of the protein encoded by the gene have the characteristics that make it a new target for drugs and in case of an alteration in that gene, we observed a phenotype that characterizes a genetic based illness. To determine these characteristics, we built, analyzed and determined the characteristics of the topology of the integrated molecular interactions network among human genes containing physical interactions between proteins, metabolic interactions and interactions of transcriptional regulation, and included other data such as level of gene transcription and cellular localization of the protein encoded by the gene. We tested our model in training sets and achieved results equal or better than the ones achieved by similar methods in the literature. Finally, with the purpose of investigating whether the assigned scores resembles the potential druggabilities and morbities of the previously unclassi ed genes, we looked for evidences in biomedical literature supporting the potential druggability and morbidity status of genes with the 10 highest scores. We found clear evidences for 73% and 90% of potential druggable and morbid genes respectively

Análise estrutural de Tie-Rod pelo método dos elementos finitos e através de cálculos analíticos

Currently one of the great concerns of the aeronautical industry is in relation to the security and integrity of the aircraft and its equipments / components when under critical flight maneuvers such as during landing / takeoff and emergency maneuvers. The engineers, technicians and scientists are constantly developing new techniques and theories to reduce the design time and testing, ir order to minimize costs. More and more the Finite Element Method is used in the structural analysis of a project as well as theories based on experimental results. This work aimed to estimate the critical load to failure for tensile, compression and buckling of the Tie-Rod, a fixture aircraft widely used on commercial aircrafts. The analysis was performed by finite element method with the assistance of software and by analytical calculations. The results showed that the Finite Element Method provides relative accuracy and convenience in the calculations, indicating critical load values slightly lower than those found analytically for tension and compression. For buckling, the Finite Element Method indicates a critical load very similar to that found analytically following empirical theories, while Euler's theory results in a slightly higher value. The highest risk is to fail by buckling, but the geometric irregularity of Tie-Rod pieces makes difficult the calculations, therefore a practical test must be done before validation of the results

Indústria automobilística brasileira entre os anos 90 e os 2000: uma análise acerca da estratégia de plataformas

Este trabalho faz um estudo comparativo sobre a estratégia de plataformas na indústria automobilística brasileira entre os anos 90 e 2000. Para tanto, definiu-se o conceito de plataformas na indústria automobilística, a intensificação dos estudos sobre sua eficiência ao longo do tempo e o impacto da reutilização e adaptação de plataformas na redução de custos. Os resultados do estudo colaboraram no entendimento dos projetos de desenvolvimento de produto na indústria automotiva nacional, colaborando para a comparação entre a evolução do cenário brasileiro com a de outros cenários como Reino Unido e os BRICs

Análise crítica de contratos técnicos como ferramenta para melhoria da gestão da manutenção

Currently, due to the highly competitive search among industries are becoming more tools for managing product that provides higher availability and therefore profitability. Maintenance as a strategic sector and of fundamental importance in business, it seeks to maximize availability and available resources, minimizing costs and waste, which directly impacts the company's results. The present work has as main objective the review of contracts for maintenance services for companies contracted by a chemical company in the Paraíba Valley, since most of its maintenance services are outsourced, and raise these contracts which are more critical and higher risk to the company's success, thus creating a tool for decision-making by maintenance managers in the act of seeking renewals or new contracts to provide services. As a result after drawing up a standard procedure for contracting of services and a better structuring of the same, we developed a method for the calculation of the criticality of the contracts and based on these calculations, charts were prepared which showed that the current scenario of maintenance contracts the company studied. Thus it is possible to evaluate the contracts which are most critical to the success or failure of the company studied, and also pave the way for further studies on how this criticality of a contract can affect the relationship, the contractor x contracted

Análise do gerenciamento de projetos de produtos na área de desenvolvimento de motores em uma indústria automotiva

L'un des facteurs nécessaires pour qu’une entreprise reste compétitive sur le marché est la création ou l'amélioration d'un produit afin qu’il réponde aux besoins et aux attentes des clients, ainsi, le Processus de Développement de Produits (PDP) est essentiel. Pour la réussite du PDP, il est souhaitable de suivre un système standard de gestion de projet. L'objectif de cette étude est d'analyser la gestion de projets dans le processus de développement de produits dans l'industrie automobile afin d'identifier les possibilités d’amélioration. Par conséquent, nous avons procédé à une revue de littérature sur le sujet, analysé les lignes directrices et les pratiques du processus de développement de produit dans l’entreprise. Comme résultat, il a été obtenu que le système de développement de produits créé par l’entreprise requiert la clarification des outils utiles à la gestion de projet. Un problème de communication et de gestion des coûts a également été constaté dans le domaine du développement du moteur lourd

Análise comparativa entre sistemas de resfriamento de injeção de plástico

This study aims to prove the economic feasibility of the installation of mechanical compression chillers on plastic injection molding machines in order to reduce the production cycle time of toothbrush cables in a specific case study. This evidence was confirmed by the comparative analysis of the system replaced and the new system installed. The old system had only one closed loop cooling tower which pumped chilled water to the injection molds, and the new system has the same tower sending cold water to the condensers of individual chillers installed on each injection machine. We conducted an analysis of energy efficiency in each system, showing that in terms of thermal efficiency virtually nothing has changed, but in terms of electricity demand the new system consumes 60.3 kW more. We conducted an analysis of machine productivity for both systems, showing a much higher productivity of the new system due to reduced cycle times caused by the presence of chillers and their greater cooling capacities. Equipped with data such as electricity rates, increases in operating costs and initial investments, the increase in consumption and demand of electricity plus the cycle time reduction were also calculated over so the simple payback 1 year and 2 months was reached

Análise doprojeto de expansãode um armazém por meio da elaboração de um layout e análise de investimento: estudo de caso em uma fábrica do setor alimentício

The proper management of materials storage is essential to supply the needs of production and reduce the inventory costs. Moreover, an effective layout contributes to improve the productivity and reduce the operational costs of a warehouse. This way, the purpose of this study was: to propose an expansion project to the warehouse of a factory in the food sector, suggesting a layout that best fit their needs and to verify its economic feasibility. To achieve this goal, it was applied methods such as ABC curve, spaghetti diagram and concepts of economics engineering to the analysis of investment in the project. The results showed that the second layout model was better than the first, supporting the storage capacity required by the company and presenting an internal movement more efficient. However, with the investment analysis, it was found that it was not feasible, given the conditions of the company, investing in the expansion of the warehouse

Um estudo de caso sobre os custos de transação de se utilizar os cartórios de registro de imóveis

O presente trabalho procura colocar a tona – a partir de leituras bibliográficas, conversas e entrevistas com donos de cartórios – a questão fundiária no Brasil, mais especificamente no município de Araraquara; tendo como eixo estruturante a evolução histórica, as leis e a legislação que regem essa instituição; além disso, há uma discussão sobre as teorias a respeito dos direitos de propriedade e custos de transação. Por fim, serão calculados os dispêndios para a compra/venda de uma propriedade rural, observando o porquê de alguns donos de imóveis rurais não registram, ou quando o fazem não é acompanhado do cadastro que compete ao INCRA

Análise de desempenho de lâmpadas LEDs e LFCs como alternativas em iluminação residencial em função da implementação da portaria ministerial n° 1007 que limita o uso de lâmpadas incandescentes no Brasil

With the imposition of the suspension of production and subsequent banning of incandescent light bulbs will be necessary to replace it by other more energy-efficient. Although the main alternative is the compact fluorescent lamp, the environmental impact caused by it due to incorrect disposal and the amount of harmonics included in the network resulting in losses related to the quality of electric power system makes them sought new alternatives for lighting systems that are efficient and have low environmental impact. In this context, the LED (Lighting Emitting Diode), based on solid-state components, is presented as an option for new projects and replacement of existing lighting. In this work we studied aspects of energy, environmental and economic impacts of a possible replacement of conventional lighting systems for new technology. From laboratory tests and surveys of the costs of different types of lamps used for residential lighting, we performed a comparative analysis considering energy and economic aspects which showed that the LED technology, but has a high initial investment, it is best when power quality and environmental preservation are relevant factors in decision making for the choice of technology to be used in the lighting system

Utilização do método de tomada de decisão multicritério PROMETHEE II para priorização do plano de ação de redução de custos de manutenção

In the last years, the maintenance took an essential role inside the productive system. Plan and manage the maintenance actions in an efficient way, are vital activities for higher production availability. This paper presents an application of a Multicriteria Decision Analysis method in a chemical industry, willing to priories a plan action for the reduction of the maintenance cost. The method used was the PROMETHEE II, with it the results were obtained through the softwares Microsoft Excel and Decision Lab

Projeto DMAIC com ferramentas six sigma para redução de custos logísticos de uma multinacional

This work has a focus on project execution DMAIC ( Define Measure Analyze Implement Control) , using the statistical and quality tools to identify , analyze and implement improvements in a given process in order to reduce costs telephony transport of a multinational consumer goods . The multinational consumer goods to be studied has outsourced carriers who perform the distribution of its products , which may lead them straight to their factories or one of its distribution centers to the points of sale ( supermarkets , bakeries , gas stations , convenience cafeterias , among others ) . Whenever there is an unexpected situation or some problem at the time of delivery of the goods to the customer opens an occurrence , ie , the carrier responsible for contacts ( 0800 ) with the contact center company of consumer goods which in turn registers the occurrence, analyzes and sends a response action to the carrier . This work will study the problem with a high number of connections to handle occurrence , through analysis and data collection , identify improvement opportunities, implement them and monitor the results to ensure that the gain and loss reduction are sustainable

Estudo comparativo do desempenho empresarial no Brasil e na China no período de 2005-2009: uma análise de empresas de capital aberto do setor de siderurgia

A teoria em finanças tem evoluído cada vez mais aproximando a teoria financeira às práticas reais adotadas nas empresas e nos mercados financeiros. A partir de Modigliani e Miller, que contribuíram para o ramo das finanças com a teoria da Irrelevância Financeira, o caminho se abriu para uma série de debates a cerca da importância das variáveis financeiras na determinação do valor da empresa. Foram levantados questionamentos a respeito da perfeição dos mercados e apresentado argumentos como a assimetria de informações, os custos de agência, a restrição financeira e outras implicações à teoria do investimento. Atualmente o que se sabe é que o fator investimento está altamente ligado às finanças e, portanto, relaciona-se com os meios de financiamento presentes no mercado e com a organização interna e financeira das firmas, esse ramo de estudo recebe o nome de Finanças Corporativas. Diante da teoria financeira, o objetivo é analisar a indústria siderúrgica de duas economias atualmente em destaque, Brasil e China através da análise econômico-financeira de quatro empresas de capital aberto do setor: Gerdau, Usiminas, Baosteel e Masteel. Cabe destacar que a indústria siderúrgica é base para outras indústrias, como construção civil, automóveis, máquinas, entre outros e, por isso, é tida como sinalizadora do desenvolvimento econômico de um país, assim também, o Brasil e a China são caracterizados como grandes potenciais emergentes e fontes de atração de investimentos internacionais

Análise do consumo de energia elétrica e da eficiência energética em uma indústria de processamento de madeira

In the industries of wood processing (sawmills), where timber is sawn in equipment such as band saws, circular saws, trowel, thicknessers, among others, that mechanically transform this resource and use of electric motors, which are not unusually poorly scaled working or overloaded, often a factor that is not found in these industries and has fundamental importance in the production process is energy efficiency that is achieved by both technological innovation and through all the practices and policies that aim to lower energy consumption, lowering energy costs and increasing the amount of energy offered no change in generation. For both during the design of an electrical installation, both overall and in various sectors of the installation, investigations are necessary, considerations and uses of variables and factors that put into practice the theme of energy efficiency. Therefore, in this paper, these factors were calculated and analyzed for a wood processing industry (sawmill) in the municipality of Taquarivaí - SP, namely: active power, power factor, demand factor and load factor. Where they were small in relation to the literature, these events that occur when devices are connected at the same time and due to the conditions of processing the wood, where the engines have large variations in electricity consumption during the unfolding of the same, due to efforts with the load and idle moments between each machining operation in the equipment

Enfermagem e o gerenciamento de custos: revisão sistemática nacional e internacional

Objectives: conduct a systematic review of national and international literature, to classify the types of production, comparing the two literatures and synthesize knowledge in the area. Method: Systematic Review of Literature, in the databases LILACS, CINAHL and MEDLINE for selection of articles in their entirety, the data extracted from the articles selected were: the study of bibliographic information (title, author, journal, place of study and year of publication), and general information (multidisciplinary production or specific area, language, type of study, type of population and contributions of the study). The categories established for classification of publications were: raising the cost of procedures/ interventions, economic evaluation of specific intervention, inclusion of nursing in the economic context, using cost as an important variable in the study. Results: The study included 39 publications, with 31% of national production and the remaining 69%, internationally. Most publications were classified according to category of economic evaluation of specific intervention, followed by the category of raising the cost of procedure / intervention, which fits the majority of national production. Human resources is shaped as an important variable for obtaining cost studies that proposed to make this calculation. Conclusion: The production of literature in nursing cost management is relevant in number of publications within the proposed period and is directed to different areas within this theme. There are significant differences in national and international literature: these last use more accurate methods, have more content theorized, use more the economic evaluation tools and related more costs with a amplified context. The production of such knowledge should continue as far as possible and putting that knowledge relating the current reality, in order to amplify the field of nursing and add value

Utilização de técnicas de planejamento de experimentos na análise de viabilidade de alterações no processo de pintura de grades Antracite em uma indústria automotiva

The search for better performance and competitive advantage in the current market scenario has made organizations keep their focus on quality planning and the use of effective techniques aimed at continuous improvement and optimization of processes and resources. The situation is not different for the painting process in the automotive industry, which has a significant amount of variables and influential external factors. This work, developed at General Motors in São José dos Campos, aims to analyze the feasibility of changing the painting process of the pickup S10 railings in the Antracite color located in the main line to the another line located in a Painting Repair Booth at the plant and, therefore, to study the possibility about reducing the window of cure for Antracite’s enamel by using Design of Experiments’ techniques. Applying this method is possible to find the best arrangement among studied factors of Painting Repair Booth that are, in this case, the Temperature, in Celsius degrees, and Skid’s Steps, in seconds, and it’s also possible to get their behavior according to quality requirements specified by GM rules for the Brightness and Paint Adhesion on the part. As a result, it can conclude that is possible to paint the S10 Antracite railings in the painting process’ line of Painting Repair Booth, and with the new configuration obtained by the Design of Experiments for the process variables, there are significant gains related to the parts’ quality, costs reduction and the optimization of production capacity, much in the main line as in the line of the Painting Repair Booth