929 resultados para Sitio de Bilbao, 1874


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Helburuak: Material honek zirkuituen laborategiko euskarria izatea du helburu. Zirkuituak materia Ingeniari Elektrikoen formazioan oinarrizkoa da. Laborategian ikasleek lehenengoz jarriko dira harremanetan, beren formakuntzan zehar berebiziko garrantzia edukiko duten hainbat, tresna, prozedura eta programa informatikoekin. Baita lan egiteko modu berri batekin ere: aurre ikasketa autonomoa, saikuntza, hausnarketa. Horregatik material honek praktika bakoitzerako hiru ataletan banatuta dago: aurre ikasketa autonomorako garatu diren oinarrizko kontzeptuak eta simulazioa; laborategian bertan egingo diren saiakuntza, muntaketak eta datuen bilketa; eta, azkenik, hausnarketarako testuan txertatuko galderak. Lan egiteko modu honek laborategiko jarduera mekanikoa gainditzeko aukera ematen du, hausnarketa eta ikasgaiko eduki teorikoen ulermena bultzatuz. Norentzat izan daiteke baliagarria: Ingeniaritza elektrikorako dago bideratuta batik bat. Baina aurre ikasketa autonomoaren atala edozein ingeniaritzako ikaslek erabil dezake, sistema elektrikoen hainbat kontzeptu eta tresnen erabilera ulertzeko.

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1 carta (mecanografiada) ; 210x290mm. Ubicación: Caja 1 - Carpeta 5

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Duración (en horas): Más de 50 horas. Destinatario: Estudiante y Docente

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7 cartas (mecanografiadas) ; entre 215x286mm y 157x215mm. Ubicación: Caja 1 - Carpeta 10

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5 cartas (manuscritas y mecanografiadas) ; 215x160mm. Ubicación: Caja 1 - Carpeta 12

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Humans infected with Bordetella pertussis, the whooping cough bacterium, show evidences of impaired host defenses. This pathogenic bacterium produces a unique adenylate cyclase toxin (ACT) which enters human phagocytes and catalyzes the unregulated formation of cAMP, hampering important bactericidal functions of these immune cells that eventually cause cell death by apoptosis and/or necrosis. Additionally, ACT permeabilizes cells through pore formation in the target cell membrane. Recently, we demonstrated that ACT is internalised into macrophages together with other membrane components, such as the integrin CD11b/CD18 (CR3), its receptor in these immune cells, and GM1. The goal of this study was to determine whether ACT uptake is restricted to receptor-bearing macrophages or on the contrary may also take place into cells devoid of receptor and gain more insights on the signalling involved. Here, we show that ACT is rapidly eliminated from the cell membrane of either CR3-positive as negative cells, though through different entry routes, which depends in part, on the target cell physiology and characteristics. ACT-induced Ca2+ influx and activation of non-receptor Tyr kinases into the target cell appear to be common master denominators in the different endocytic strategies activated by this toxin. Very importantly, we show that, upon incubation with ACT, target cells are capable of repairing the cell membrane, which suggests the mounting of an anti-toxin cell repair-response, very likely involving the toxin elimination from the cell surface.

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2 cartas (manuscritas y mecanografiadas) ; 225x170mm . Ubicación: Caja 1 - Carpeta 14

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9 cartas (manuscritas y mecanografiadas) ; entre 139x215mm y 217x274mm. Ubicación: Caja 1 - Carpeta 25

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2 cartas (mecanografiadas) ; entre 210x297mm y 215x230mm. Ubicación: Caja 1 - Carpeta 29

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9 cartas (mecanografiadas) ; 207x300mm. Ubicación: Caja 1 - Carpeta 36

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3 cartas (mecanografiadas) y 1 invitación de boda ; entre 210x274mm y 157x100mm. Ubicación: Caja 1 - Carpeta 38

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8 cartas (manuscritas) y 1 carta (manuscrita y mecanografiada) ; entre 160x180mm y 320x200mm. Ubicación: Caja 1 - Carpeta 40