S. Jérôme, sur Isaïe.

N° 80 des mss envoyés à Paris par Maugerard en octobre 1802; cf. B.n.F., département des Manuscrits, Archives Modernes 497; — abbaye d'Echternach (dioc. de Trèves), cf. titre "Continet" et cote "B 5"; 1789. Le patrimoine libéré, 152 et n° 96; — note de Gilbert Ouy: "Ce volume a lontemps porté à la suite d'une erreur la cote 9525, sa véritable cote lui a été restituée en 1958" (f. de garde)

Thébaïde et Achilléïde de Stace.

N° 5 des mss envoyés à Paris par Maugerard en octobre 1802; cf. B.n.F., département des Manuscrits, Archives Modernes 497; — abbaye d'Echternach (dioc. de Trèves), cf. titre "Continet"; 1789. Le patrimoine libéré, 152 et n° 96

"Comment. Boetii in periermenias librum Aristotelis.

N° 22 des mss envoyés à Paris par Maugerard en octobre 1802; cf. B.n.F., département des Manuscrits, Archives Modernes 497; — abbaye d'Echternach (dioc. de Trèves), cf. titre "Continet"; 1789. Le patrimoine libéré, 152 et n° 96

Passiones et vitae sanctorum.

Abbaye Saint-Maur-des-Fossés ; cf. B. de Montfaucon, Bibliotheca bibliothecarum, II, 1739, p.1141-1143 : "38. 1060. Sanctorum Vitae in compendium redactae". Ex-libris : F. 3: "Sancti Germani a Pratis" (XVIIIe s.).

S. Johannes Chrysostomus, Homiliae (1-82v, 87v-111, 132v-226v), De compunctione cordis (226v-264v), Tractatus de reparatione lapsi (264v-303).

Abbaye Saint-Maur-des-Fossés ; cf. B. de Montfaucon, Bibliotheca bibliothecarum, II, 1739, p. 1141-1143 : "60. 1083. S. Joan. Chrysostomi Homiliae de diversis.". Ex-libris : F. Bv : « Iste liber est sancti Petri... », suivi d'un anathème (Xe-XIe s.) ; f. B : "Sti Germani a Pratis" ; f. 1 : « ex libris monasterii Sancti Germani a pratis Parisiorum ». France.

Fragments de mss.

Contient : Ex canonibus; versus Tranquillini de XII ventis ; Vita Gerardi de Rosselon ; De S. Bartholomeo ; Compotus Hilperici ; Regulae Isidori et Fructuosi ; ex libro Auxilii de Formoso papa ; Sermo de S. Theoderico ; Fragments de mss. de S. Rémi de Reims, contenant des actes d'associations de prières, l'épitaphe de Lothaire, des actes d'offrandes d'enfants ; Encyclique sur la mort d'André, abbé de Chezal-Benoît ; Frotharii epistolae, etc ; De S. Maria Magdal ; Acta S. Mauritii, S. Romani, S. Felicitatis ; Vita S. Hugonis Clun ; Vita ejusdem, auctore Rainaldo, abbate Vizel ; Ejusdem vita metrica ; Ivonis Carnot. epistolae ; Vitae S. Maioli, et S. Hugonis Cluniac ; Sermo S. Hugonis de S. Marcello

Mélanges de grammaire, de dialectique et de mathématiques.

Regula Enchiriadis (3v). — Boetii commenta in isagogas (5). — Marciani Capellae astronomia (46v). — Boetii musica (60). — Gerbertus Constantino (105v). — Boetii geometria (107). — De mensuris etc. (123v et 165v). — E Julio Frontino (130v), et Columella (131). — Recettes de médecine et autres (133). — Sur les mètres (148). — Marius Plotius sacerdos de metris (150). — Musica Fortunatiani (158v).

The Tightness of the Cotton Swabs Meshing Influences the Chances of Getting Conclusive DNA Profiles

Objective: The chance of obtaining a conclusive DNA profile strongly depends on the quantity of biological material that can be recovered from a crime scene sample. Optimizing the collection strategy is therefore of prime interest. A difference in the level of tightness of the cotton meshed around the shaft has been observed between manufacturers and is hypothesized to affect the collection and subsequent release capacity of cotton swabs. Consequently, we compared the performance of cotton swabs from two different suppliers: Applimed SA and DryswabTM. Methods: These swabs were used to recover 50 ml of blood, either pure or diluted (1:1000 and 1:5000), deposited on both smooth and absorbent surfaces. Performance was compared in terms of ease of use, concentration of extracted DNA, and quality of DNA profiles. DNA quantification was obtained by real-time PCR using the QuantifilerTM Human DNA Quantification Kit. Evaluation of DNA profiles was based on profiles obtained using AmpFlSTR® NGM SElectTM PCR Amplification kit. Results: When considering smooth surfaces, recovered DNA was more concentrated when using the DryswabTM than the Applimed SA cotton swab. More precisely, DNA concentrations ranged from 15.7 to 28.8 ng/ml and 6.7 to 21.2 ng/ml, respectively for samples of pure blood. The same trend was observed for the absorbent surface, with 2.0 to 5.0 ng/ml and 0.9 to 1.4 ng/ml, respectively. Conclusion: Our results illustrate that different cotton swabs produce different results in terms of ease of use and quantity of recovered DNA and this should be taken into consideration when choosing which swab to use at both the crime scene and laboratory. More specifically, results from the present study suggest that looser meshing of the cotton fibres

2

The pharmacokinetic profile of imatinib has been assessed in healthy subjects and in population studies among thousands of patients with CML or GIST. Imatinib is rapidly and extensively absorbed from the GI tract, reaching a peak plasma concentration (Cmax) within 1-4 h following administration. Imatinib bioavailability is high (98%) and independent of food intake. Imatinib undergoes rapid and extensive distribution into tissues, with minimal penetration into the central nervous system. In the circulation, it is approximately 95% bound to plasma proteins, principally α1-acid glycoprotein (AGP) and albumin. Imatinib undergoes metabolism in the liver via the cytochrome P450 enzyme system (CYP), with CYP3A4 being the main isoenzyme involved. The N-desmethyl metabolite CGP74588 is the major circulating active metabolite. The typical elimination half-life for imatinib is approximately 14-22 h. Imatinib is characterized by large inter-individual pharmacokinetic variability, which reflects in a wide spread of concentrations observed under standard dosage. Besides adherence, several factors have been shown to influence this variability, especially demographic characteristics (sex, age, body weight and disease diagnosis), blood count characteristics, enzyme activity (mainly CYP3A4), drug interactions, activity of efflux transporters and plasma levels of AGP. Additionally, recent retrospective studies have shown that drug exposure, reflected in either the area under the concentration-time curve (AUC) or more conveniently the trough level (Cmin), correlates with treatment outcomes. Increased toxicity has been associated with high plasma levels, and impaired clinical efficacy with low plasma levels. While no upper concentration limit has been formally established, a lower limit for imatinib Cmin of about 1000 ng/mL has been proposed repeatedly for improving outcomes in CML and GIST patients. Imatinib is licensed for use in chronic phase CML and GIST at a fixed dose of 400 mg once daily (600 mg in some other indications) despite substantial pharmacokinetic variability caused by both genetic and acquired factors. The dose can be modified on an individual basis in cases of insufficient response or substantial toxic effects. Imatinib would, however, meet traditional criteria for a therapeutic drug monitoring (TDM) program: long-term therapy, measurability, high inter-individual but restricted intra-individual variability, limited pharmacokinetic predictability, effect of drug interactions, consistent association between concentration and response, suggested therapeutic threshold, reversibility of effect and absence of early markers of efficacy and toxic effects. Large-scale, evidence-based assessments of drug concentration monitoring are therefore still warranted for the personalization of imatinib treatment.

Congenital heart defects in Europe: prevalence and perinatal mortality, 2000 to 2005.

BACKGROUND: This study determines the prevalence of Congenital Heart Defects (CHD), diagnosed prenatally or in infancy, and fetal and perinatal mortality associated with CHD in Europe. METHODS AND RESULTS: Data were extracted from the European Surveillance of Congenital Anomalies central database for 29 population-based congenital anomaly registries in 16 European countries covering 3.3 million births during the period 2000 to 2005. CHD cases (n=26 598) comprised live births, fetal deaths from 20 weeks gestation, and terminations of pregnancy for fetal anomaly (TOPFA). The average total prevalence of CHD was 8.0 per 1000 births, and live birth prevalence was 7.2 per 1000 births, varying between countries. The total prevalence of nonchromosomal CHD was 7.0 per 1000 births, of which 3.6% were perinatal deaths, 20% prenatally diagnosed, and 5.6% TOPFA. Severe nonchromosomal CHD (ie, excluding ventricular septal defects, atrial septal defects, and pulmonary valve stenosis) occurred in 2.0 per 1000 births, of which 8.1% were perinatal deaths, 40% were prenatally diagnosed, and 14% were TOPFA (TOPFA range between countries 0% to 32%). Live-born CHD associated with Down syndrome occurred in 0.5 per 1000 births, with > 4-fold variation between countries. CONCLUSION: Annually in the European Union, we estimate 36 000 children are live born with CHD and 3000 who are diagnosed with CHD die as a TOFPA, late fetal death, or early neonatal death. Investing in primary prevention and pathogenetic research is essential to reduce this burden, as well as continuing to improve cardiac services from in utero to adulthood.

Projecte de construcció d’una granja de boví de llet a Nador (nord-est del Marroc)|

L'objectiu del projecte és la construcció d'una granja de boví de llet a la regió del Rif oriental, concretament al municipi de Nador (Nord Est del Marroc). A la granja es construiran sis naus, les quals comptaran amb les dependències necessàries per al desenvolupament de l'activitat, amb una superfície construïda total de 18.105 m². Aquestes naus seran equipades amb les instal•lacions, maquinària i equips necessaris per al correcte desenvolupament de l'activitat. Es tracta d’una instal•lació de 1000 vaques adultes per a la producció de llet tenint per això la recria necessària

Mais quel monde voulons-nous? Entretien avec Maïté Debats, féministe engagée de Toulouse (F)

Depuis plus de 30 ans, Maïté se bat sur le terrain avec les femmes, spécialement avec des femmes victimes de violences conjugales. Elle est cofondatrice de l'APIAF (Association pour la Promotion d'Initiatives Autonomes des Femmes), centre d'accueil pour des femmes en difficulté. « Lieu d'écoute, d'information, d'orientation et d'insertion pour les femmes en difficulté, avec un accueil spécifique pour les femmes victimes de violences conjugales », l'APIAF fut créée à Toulouse en 1981 et adhère à la Fédération Nationale Solidarité Femmes (FNSF). Chaque année, l'APIAF accueille environ 1000 femmes victimes de violences conjugales et 1200 enfants. Maïté participe aussi au comité d'éthique et au service de formation de la FNSF. Quartiers Nord de Toulouse. Durant cette période, en tant que militante féministe, elle s'est intéressée à la pratique culturelle de la vidéo et à son utilisation comme outil d'expression engagée. Plusieurs de ses documentaires et reportages ont été tournés avec Carol Prestat. Maïté utilise cet outil dans ses interventions, tant auprès des femmes - parmi les documentaires qu'elle a réalisés : "Cinq femmes et des mariages", "Des dames comme tout le monde" (avec des femmes chômeuses) et "Prends garde à toi!" (sur l'intervention professionnelle auprès de femmes victimes de violences conjugales) - que des jeunes - une de ces vidéos, « Salah, Malik, Beurs », a donné naissance au groupe de musique Zebda. Ce travail avec les jeunes l'a amenée à mettre sur pied l'Association Vitécri, visant à réaliser des films et organiser des activités culturelles avec des jeunes des quartiers populaires issu·e·s de l'immigration postcoloniale.

Reconstructing paleoelevation in eroded orogens

Hydrogen isotope and Ar-40/Ar-39 geochronological data are presented from muscovite within a crustal-scale extensional detachment of the Shuswap Metamorphic Complex, North American Cordillera. The hydrogen isotope compositions (deltaD(ms)) of precisely dated muscovite attain values as low as -156parts per thousand in the detachment mylonite, whereas footwall quartzite has a deltaD(ms) value of -81parts per thousand. The very low deltaD(ms) values in the detachment are best explained by infiltration of meteoric water, with maximum deltaD values of -135parts per thousand +/- 3parts per thousand, during extensional unroofing of the orogen at 49.0-47.9 Ma. On the basis of the empirically determined relationship between elevation and isotopic composition of precipitation, the reconstructed early Eocene paleoelevations of the orogen are 4060 +/- 250 m to 4320 +/- 250 m, at least 1000 m higher than the highest present-day peaks. We propose that the isotopic composition of surface-derived waters in extensional detachments represents a newly recognized method to estimate maximum paleoelevations attained immediately preceding extensional orogenic collapse.