North American herpetology : or, A description of the reptiles inhabiting the United States / by John Edwards Holbrook.

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North American herpetology : or, A description of the reptiles inhabiting the United States / by John Edwards Holbrook.

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North American herpetology : or, A description of the reptiles inhabiting the United States / by John Edwards Holbrook.

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1866-1870: Richard Baxter Foster

1st PrincipalIn Office: 1866-1870

11β-Hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

Glucocorticoid hormones, acting via nuclear receptors, regulate many metabolic processes, including hepatic gluconeogenesis. It recently has been recognized that intracellular glucocorticoid concentrations are determined not only by plasma hormone levels, but also by intracellular 11β-hydroxysteroid dehydrogenases (11β-HSDs), which interconvert active corticosterone (cortisol in humans) and inert 11-dehydrocorticosterone (cortisone in humans). 11β-HSD type 2, a dehydrogenase, thus excludes glucocorticoids from otherwise nonselective mineralocorticoid receptors in the kidney. Recent data suggest the type 1 isozyme (11β-HSD-1) may function as an 11β-reductase, regenerating active glucocorticoids from circulating inert 11-keto forms in specific tissues, notably the liver. To examine the importance of this enzyme isoform in vivo, mice were produced with targeted disruption of the 11β-HSD-1 gene. These mice were unable to convert inert 11-dehydrocorticosterone to corticosterone in vivo. Despite compensatory adrenal hyperplasia and increased adrenal secretion of corticosterone, on starvation homozygous mutants had attenuated activation of the key hepatic gluconeogenic enzymes glucose-6-phosphatase and phosphoenolpyruvate carboxykinase, presumably, because of relative intrahepatic glucocorticoid deficiency. The 11β-HSD-1 −/− mice were found to resist hyperglycamia provoked by obesity or stress. Attenuation of hepatic 11β-HSD-1 may provide a novel approach to the regulation of gluconeogenesis.

O problema do direito civil do imigrante e a queda do gabinete de olinda, 1866

Bibliografia

Sample-to-sample fluctuations of the overlap distributions in the three-dimensional Edwards-Anderson spin glass

We study the sample-to-sample fluctuations of the overlap probability densities from large-scale equilibrium simulations of the three-dimensional Edwards-Anderson spin glass below the critical temperature. Ultrametricity, stochastic stability, and overlap equivalence impose constraints on the moments of the overlap probability densities that can be tested against numerical data. We found small deviations from the Ghirlanda Guerra predictions, which get smaller as system size increases. We also focus on the shape of the overlap distribution, comparing the numerical data to a mean-field-like prediction in which finite-size effects are taken into account by substituting delta functions with broad peaks.

Static versus dynamic heterogeneities in the D=3 Edwards-Anderson-ising spin glass

We numerically study the aging properties of the dynamical heterogeneities in the Ising spin glass. We find that a phase transition takes place during the aging process. Statics-dynamics correspondence implies that systems of finite size in equilibrium have static heterogeneities that obey finite-size scaling, thus signaling an analogous phase transition in the thermodynamical limit. We compute the critical exponents and the transition point in the equilibrium setting, and use them to show that aging in dynamic heterogeneities can be described by a finite-time scaling ansatz, with potential implications for experimental work.

Ficción y realidad en "Les Bienveillantes" de Jonathan Littell

En el presente trabajo se analiza "Les Bienveillantes", novela que ficciona las memorias atormentadas de un nazi. A través de su lectura se viaja a los infiernos del holocausto, de la guerra y de una conciencia sin anclajes éticos ni estéticos, narrados por una mente perversa que apenas se conmueve ante las atrocidades más profundas. Tras contrastar a lo largo de su trama ficción y realidad, se destaca, a la luz de los debates sobre la reescritura de la Historia, la operatividad de esta novela para captar y transmitir la verdad de lo ocurrido favoreciendo de ese modo el desarrollo de una conciencia responsable y la no repetición de los hechos.

Guerras europeas, conflictos civiles, proyectos nacionales. Una interpretación de las restauraciones napolitanas (1799-1866)

La elección de examinar la contrarrevolución a través de sus mayores éxitos, las cuatro restauraciones victoriosas, y su derrota, la restauración fallida, puede enriquecer las perspectivas tradicionales sobre la resistencia y la crisis del Reino de las dos Sicilias. Los conflictos europeos, las guerras civiles, las construcciones estatales y la creación de identidades nacionales modernas son fenómenos que se entrecruzan con la complicada historia del reino napolitano. A través de la perspectiva de las restauraciones, bien dinásticas (1799 y 1815), o bien absolutistas (1821 y 1849), podemos insertar en un esquema interpretativo general la dialéctica entre conflicto interno y crisis internacionales, la interrelación con la formación de las ideas y adscripciones nacionalistas y la comparación con la contrarrevolución en el mundo borbónico. El paradigma del conflicto nos permite también el contraste con el más amplio mundo borbónico, francés y, sobre todo, iberoamericano. De este modo podemos reflexionar tanto sobre el éxito del legitimismo napolitano como sobre los términos de su derrota en 1860 y sobre las razones de su reciente fortuna en el imaginario colectivo italiano.

North American herpetology : or, A description of the reptiles inhabiting the United States / by John Edwards Holbrook.

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