972 resultados para Receptor ativador de fator nuclear Kappa-B


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We consider an integrable conformally invariant two-dimensional model associated to the affine Kac-Moody algebra sl3(ℂ). It possesses four scalar fields and six Dirac spinors. The theory does not possesses a local Lagrangian since the spinor equations of motion present interaction terms which are bilinear in the spinors. There exists a submodel presenting an equivalence between a U(1) vector current and a topological current, which leads to a confinement of the spinors inside the solitons. We calculate the one-soliton and two-soliton solutions using a procedure which is a hybrid of the dressing and Hirota methods. The soliton masses and time delays due to the soliton interactions are also calculated. We give a computer program to calculate the soliton solutions. © 2002 Published by Elsevier Science B.V.

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We use the CP trajectory diagram as a tool for pictorial representation of the genuine CP and the matter effects to explore the possibility of an in situ simultaneous measurement of δ and the sign of Δℳ13 2. We end up with a low-energy conventional superbeam experiment with a megaton-class water Cherenkov detector and baseline length of about 700 km. A picturesque description of the combined ambiguity which may arise in simultaneous determination of θ13 and the above two quantities is given in terms of CP trajectory diagram.

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We introduce and study new integrable models (IMs) of An (1)-nonabelian Toda type which admit U(1) ⊗ U(1) charged topological solitons. They correspond to the symmetry breaking SU(n + 1) → SU(2) ⊗ SU(2) ⊗ U(1)n-2 and are conjectured to describe charged dyonic domain walls of N = 1 SU(n + 1) SUSY gauge theory in large n limit. It is shown that this family of relativistic IMs corresponds to the first negative grade q = -1 member of a dyonic hierarchy of generalized cKP type. The explicit relation between the 1-soliton solutions (and the conserved charges as well) of the IMs of grades q = -1 and q = 2 is found. The properties of the IMs corresponding to more general symmetry breaking SU(n + 1) → SU(2)⊗p ⊗ U(1)n-p as well as IM with global SU(2) symmetries are discussed. © 2002 Elsevier Science B.V. All rights reserved.

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Supersymmetry is formulated for integrable models based on the sl(2 1) loop algebra endowed with a principal gradation. The symmetry transformations which have half-integer grades generate supersymmetry. The sl(2 1) loop algebra leads to N=2 supersymmetric mKdV and sinh-Gordon equations. The corresponding N=1 mKdV and sinh-Gordon equations are obtained via reduction induced by twisted automorphism. Our method allows for a description of a non-local symmetry structure of supersymmetric integrable models. © 2003 Elsevier B.V. All rights reserved.

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After constructing a BRST operator from the fermionic Green-Schwarz constraints and a bosonic pure spinor ghost variable, the superstring is covariantly quantized and N-point tree amplitudes are computed in a manifestly ten-dimensional super-Poincaré covariant manner. © 2004 Published by Elsevier B.V.

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Quadratic gravity in (2+1)D is nonunitarity at the tree level. When a topological Chern-Simons term is added to this theory, the harmless massive scalar mode of the former gives rise to a troublesome massive spin-0 ghost, while the massive spin-2 ghost is replaced by two massive physical particles both of spin-2. Therefore, unlike what it is claimed in the literature, quadratic Chern-Simons gravity in (2+1)D is nonunitary at the tree level. © 2004 Published by Elsevier B.V.

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A numerical study of the non-oscillatory reheating mechanism in a quintessential inflation context shows that high reheating temperature can be achieved compared with the usual reheating mechanism in which particles are produced gravitationally. We find that even for a very small coupling between the inflaton field and a massless scalar field, the non-oscillatory reheating production of particles dominates over the gravitational production mechanism. © 2004 Published by Elsevier B.V.

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We consider a scalar field theory on AdS, and show that the usual AdS/CFT prescription is unable to map to the boundary a part of the information arising from the quantization in the bulk. We propose a solution to this problem by defining the energy of the theory in the bulk through the Noether current corresponding to time displacements, and, in addition, by introducing a proper generalized AdS/CFT prescription. We also show how this extended formulation could be used to consistently describe double-trace interactions in the boundary. The formalism is illustrated by focusing on the non-minimally coupled case using Dirichlet boundary conditions. © 2004 Published by Elsevier B.V.

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Among other things, the pure spinor formalism has been used to rederive some particular superstring scattering amplitudes in the last few years. I will briefly review how the computations were done and show that the kinematical factors of these amplitudes can be simply written as integrals in a pure spinor superspace. © 2007 Elsevier B.V. All rights reserved.

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Presently it is well known that neutrino oscillation data are well described by massive neutrinos and their mixing. This suggests changes in the standard model (SM) and makes the flavor physics even more interesting. Recently, it has been proposed a multi-Higgs extension of the SM with Abelian and non-Abelian discrete symmetries which seeks to explain the origin of the masses and mixing matrices in all charge sectors. © 2012 Elsevier B.V.

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Pós-graduação em Pesquisa e Desenvolvimento (Biotecnologia Médica) - FMB

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)

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Pós-graduação em Odontologia - FOA

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Prostatic lesions such as prostatic intraepithelial neoplasia (PIN) and proliferative inflammatory atrophy (PIA) are studied in human and canine species due to their malignance potential. The plasminogen activator (PA) system has been suggested to play a central role in cell adhesion, angiogenesis, inflammation, and tumor invasion. The urokinase-type plasminogen activator receptor (uPAR) is a component of the PA, with a range of expression in tumor and stromal cells. In this study, uPAR expression in both canine normal prostates and with proliferative disorders (benign prostatic hyperplasia-BPH, proliferative inflammatory atrophy-PIA, prostatic intraepithelial neoplasia-PIN, and carcinoma-PC) was evaluated by immunohistochemistry in a tissue microarray (TMA) slide to establish the role of this enzyme in extracellular matrix (ECM) remodeling and in the processes of tissue invasion. A total of 298 cores and 355 diagnoses were obtained, with 36 (10.1%) normal prostates, 46 (13.0%) with BPH, 128 (36.1%) with PIA, 74 (20.8%) with PIN and 71 (20.0%) with PC. There is variation in the expression of uPAR in canine prostate according to the lesion, with lower expression in normal tissue and with BPH, and higher expression in tissue with PIA, PIN and PC. The high expression of uPAR in inflammatory and neoplastic microenvironment indicates increased proteolytic activity in canine prostates with PIA, PIN, and PC.

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Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)