Daily meditations: or, Quotidian preparations for and considerations of death and eternity begun July 19. 1666 /

"A postscript to the reader."--p. [17-18], in verse; signed: M.J. [i.e., Marmaduke Johnson]. In the first issue (1668; Evans 128) the identical postscript is signed: J.T.

Union list of periodicals in pharmaceutical libraries.

"Published under the auspices of the Pharmaceutical Section, Science-Technology Division, Special Libraries Association."

Merck's Annual Report of Recent Advances in Pharmaceutical Chemistry and Therapeutics

Title Varies: 1898-1900, Annual Report; 1906- Report on the Advancements of Pharmaceutical Chemistry and Therapeutics; 1909-14, E. Merck's Annual Report of Recent Advances In Pharmaceutical Chemistry and Therapeutics

Inorganic general, medical and pharmaceutical chemistry, theoretical and practical; a text-book and laboratory manual, containing theoretical, descriptive, and technological chemistry;

Mode of access: Internet.

Physiology for pharmaceutical students,

Mode of access: Internet.

Yakugaku zasshi : the Journal of the Pharmaceutical Society of Japan

Added title in English.

Pharmaceutical bacteriology,

Mode of access: Internet.

A compendium of the anatomy of the human body : intended principally for the use of students ... This edition is prefixed with A compendious history of anatomy, and The Ruyschian art and method of making preparations to exhibit the structure of the human body, illustrated with a representation of the quicksilver tray and its appendages, which is not in the London edition.

"A compendious history of anatomy" and "The Ruyschian art and method of making preparations to exhibit the structure of the human body" (32 p. at front of v. 1) are by Robert Hooper, and are reprinted, with slight changes in text, from his The anatomist's vade-mecum, 4th ed., London, 1802.

Medical lexicon. A dictionary of medical science; containing a concise explanation of the various subjects and terms of physiology, pathology, hygiene, therapeutics, pharmacology, obstetrics, medical jurisprudence, & c., with the French and other synonymes ; notices of climate, and of celebrated mineral waters; formulae for various officinal, empirical, and dietetic preparations, etc.

Mode of access: Internet.

Practical druggist and pharmaceutical review of reviews.

Mode of access: Internet.

Year Book of the American Pharmaceutical Association.

Vol. 1 published in Scio, Ohio; v. 2-12, in Chicago; v. 13-19, in Baltimore; v. 20-23 in Washington.

Asthma management by New Zealand pharmacists: a pharmaceutical care demonstration project

Background: Pharmaceutical care services became recognized in New Zealand in the mid-1990s, albeit with limited evidence of the acceptability and effectiveness of the model. An asthma-specific pharmaceutical care service was trialled in southern New Zealand, based on a 'problem-action-outcome' method, with pharmacists adopting a patient-centred, outcome-focused approach with multidisciplinary consultation. Objective: To report on the implementation and outcomes of a specialist asthma service offered by community pharmacists. Design: Pharmacists in five pharmacies, servicing predominantly rural, established clientele, received training in the asthma service and research documentation. Ten patients per pharmacy were recruited in each year (years 1 and 2) of the study. The patients were entered into the study in cohorts of five per pharmacy twice yearly, with year 2 mirroring year 1. The phase-in design minimized the impact on the pharmacists. The patients acted as their own controls. All patients received individualized care and had approximately monthly consultations with the pharmacist, with clinical and quality of life (QoL) monitoring. Results: A total of 100 patients were recruited. On average, 4.3 medication-related problems were identified per patient; two-thirds of them were compliance-related. The most common interventions were revision of patients' asthma action plans, referral and medication counselling. Clinical outcomes included reduced bronchodilator use and improved symptom control in around two-thirds of patients. Asthma-specific QoL changes were more positive and correlated well with clinical indicators. Conclusion: Further research is warranted to integrate this service into daily practice. Clinical outcomes were generally positive and supported by QoL indicators. Characteristics of New Zealand practice and this sample of pharmacies may limit the generalizability of these findings.

Physical enhancement of transdermal drug application: is delivery technology keeping up with pharmaceutical development?

Advances in molecular biology have given us a wide range of protein and peptide-based drugs that are unsuitable for oral delivery because of their high degree of first-pass metabolism. Though parenteral delivery is the obvious answer, for the successful development of commercial chronic and self-administration usage formulations it is not the ideal choice. Transdermal delivery is emerging as the biggest application target for these agents, however, the skin is extremely efficient at keeping out such large molecular weight compounds and therapeutic levels are never going to be realistically achieved by passive absorption. Physical enhancement mechanisms including: iontophoresis, electroporation, ultrasound, photomechanical waves, microneedles and jet-propelled particles are emerging as solutions to this topical delivery dilemma. Adding proteins and peptides to the list of other large molecular weight drugs with insufficient passive transdermal fluxes to be therapeutically useful, we have a collection of pharmacological agents waiting for efficient delivery methods to be introduced. This article reviews the current state of physical transdermal delivery technology, assesses the pros and cons of each technique and summarises the evidence-base of their drug delivery capabilities.

Solution structure of the cyclotide palicourein: Implications for the development of a pharmaceutical framework

The cyclotides are a family of disulfide-rich proteins from plants. They have the characteristic structural features of a circular protein backbone and a knotted arrangement of disulfide bonds. Structural and biochemical studies of the cyclotides suggest that their unique physiological stability can be loaned to bioactive peptide fragments for pharmaceutical and agricultural development. In particular, the cyclotides incorporate a number of solvent-exposed loops that are potentially suitable for epitope grafting applications. Here, we determine the structure of the largest known cyclotide, palicourein, which has an atypical size and composition within one of the surface-exposed loops. The structural data show that an increase in size of a palicourein loop does not perturb the core fold, to which the thermodynamic and chemical stability has been attributed. The cyclotide core fold, thus, can in principle be used as a framework for the development of useful pharmaceutical and agricultural bioactivities.

The stability of lipidic analogues of GnRH in plasma and kidney preparations: the stereoselective release of the parent peptide

The conjugation of a lipoamino acid to the N-terminus of Gonadotropin releasing hormone (GnRH) produces a lipophilic peptide from which the parent GnRH peptide is released into solution on treatment with plasma and kidney enzyme preparation. Our findings show that one stereoisomer of the Laa is cleaved very rapidly, providing a bolus dose of the peptide while the opposite stereoisomer is cleaved much more slowly, providing prolonged elevation of peptide concentration. The Laa-Glu linkage appears to act as a two phase prodrug system. © 2005 Elsevier Ltd. All rights reserved.