'Artificial Immune Systems Tutorial'

The biological immune system is a robust, complex, adaptive system that defends the body from foreign pathogens. It is able to categorize all cells (or molecules) within the body as self-cells or non-self cells. It does this with the help of a distributed task force that has the intelligence to take action from a local and also a global perspective using its network of chemical messengers for communication. There are two major branches of the immune system. The innate immune system is an unchanging mechanism that detects and destroys certain invading organisms, whilst the adaptive immune system responds to previously unknown foreign cells and builds a response to them that can remain in the body over a long period of time. This remarkable information processing biological system has caught the attention of computer science in recent years. A novel computational intelligence technique, inspired by immunology, has emerged, called Artificial Immune Systems. Several concepts from the immune have been extracted and applied for solution to real world science and engineering problems. In this tutorial, we briefly describe the immune system metaphors that are relevant to existing Artificial Immune Systems methods. We will then show illustrative real-world problems suitable for Artificial Immune Systems and give a step-by-step algorithm walkthrough for one such problem. A comparison of the Artificial Immune Systems to other well-known algorithms, areas for future work, tips & tricks and a list of resources will round this tutorial off. It should be noted that as Artificial Immune Systems is still a young and evolving field, there is not yet a fixed algorithm template and hence actual implementations might differ somewhat from time to time and from those examples given here.

Super-orbital variability of LS I+61 degrees 303 at TeV energies

Context. The gamma-ray binary LS I +61º303 is a well-established source from centimeter radio up to very high energy (VHE; E > 100 GeV). The broadband emission shows a periodicity of ∼26.5 days, coincident with the orbital period. A longer (super-orbital) period of 1667 ± 8 days was proposed from radio variability and confirmed using optical and high-energy (HE; E ¿ 100 MeV) gamma-ray observations. In this paper, we report on a four-year campaign performed by MAGIC together with archival data concentrating on a search for a long-timescale signature in the VHE emission from LS I +61º303. Aims. We focus on the search for super-orbital modulation of the VHE emission, similar to that observed at other energies, and on the search for correlations between TeV emission and an optical determination of the extension of the circumstellar disk. Methods. A four-year campaign has been carried out using the MAGIC telescopes. The source was observed during the orbital phases when the periodic VHE outbursts have occurred (φ = 0.55 – 0.75, one orbit = 26.496 days). Additionally, we included archival MAGIC observations and data published by the VERITAS collaboration in these studies. For the correlation studies, LS I +61◦303 has also been observed during the orbital phases where sporadic VHE emission had been detected in the past (φ = 0.75 – 1.0). These MAGIC observations were simultaneous with optical spectroscopy from the LIVERPOOL telescope. Results. The TeV flux of the periodical outburst in orbital phases φ = 0.5 – 0.75 was found to show yearly variability consistent with the long-term modulation of ∼4.5 years found in the radio band. This modulation of the TeV flux can be well described by a sine function with a best-fit period of 1610±58 days. The complete data, including archival observations, span two super-orbital periods. There is no evidence for a correlation between the TeV emission and the mass-loss rate of the Be star, but this may be affected by the strong, short-timescale (as short as intra-day) variation displayed by the Hα fluxes.

Multiwavelength observations of the blazar 1ES 1011+496 in Spring 2008

The BL Lac object 1ES 1011+496 was discovered at Very High Energy (VHE, E>100GeV) γ-rays by MAGIC in spring 2007. Before that the source was little studied in different wavelengths. Therefore a multi-wavelength (MWL) campaign was organized in spring 2008. Along MAGIC, the MWL campaign included the Mets¨ahovi radio observatory, Bell and KVA optical telescopes and the Swift and AGILE satellites. MAGIC observations span from March to May, 2008 for a total of 27.9 hours, of which 19.4 hours remained after quality cuts. The light curve showed no significant variability yielding an integral flux above 200 GeV of (1.3 ± 0.3) × 10^(−11) photons cm^(−2) s^( −1) . The differential VHE spectrum could be described with a power-law function with a spectral index of 3.3 ± 0.4. Both results were similar to those obtained during the discovery. Swift XRT observations revealed an X-ray flare, characterized by a harder-when-brighter trend, as is typical for high synchrotron peak BL Lac objects (HBL). Strong optical variability was found during the campaign, but no conclusion on the connection between the optical and VHE γ-ray bands could be drawn. The contemporaneous SED shows a synchrotron dominated source, unlike concluded in previous work based on non-simultaneous data, and is well described by a standard one–zone synchrotron self–Compton model. We also performed a study on the source classification. While the optical and X-ray data taken during our campaign show typical characteristics of an HBL, we suggest, based on archival data, that 1ES 1011+496 is actually a borderline case between intermediate and high synchrotron peak frequency BL Lac objects.

Insights into the emission of the blazar 1ES 1011+496 through unprecedented broadband observations during 2011 and 2012

Context. 1ES 1011+496 (z = 0.212) was discovered in very high-energy (VHE, E >100 GeV) γ rays with MAGIC in 2007. The absence of simultaneous data at lower energies led to an incomplete characterization of the broadband spectral energy distribution (SED). Aims. We study the source properties and the emission mechanisms, probing whether a simple one-zone synchrotron self-Compton (SSC) scenario is able to explain the observed broadband spectrum. Methods. We analyzed data in the range from VHE to radio data from 2011 and 2012 collected by MAGIC, Fermi-LAT, Swift, KVA, OVRO, and Metsähovi in addition to optical polarimetry data and radio maps from the Liverpool Telescope and MOJAVE. Results. The VHE spectrum was fit with a simple power law with a photon index of 3.69 ± 0.22 and a flux above 150 GeV of (1.46±0.16)×10^(−11) ph cm^(−2) s^(−1) . The source 1ES 1011+496 was found to be in a generally quiescent state at all observed wavelengths, showing only moderate variability from radio to X-rays. A low degree of polarization of less than 10% was measured in optical, while some bright features polarized up to 60% were observed in the radio jet. A similar trend in the rotation of the electric vector position angle was found in optical and radio. The radio maps indicated a superluminal motion of 1.8 ± 0.4 c, which is the highest speed statistically significant measured so far in a high-frequency-peaked BL Lac. Conclusions. For the first time, the high-energy bump in the broadband SED of 1ES 1011+496 could be fully characterized from 0.1 GeV to 1 TeV, which permitted a more reliable interpretation within the one-zone SSC scenario. The polarimetry data suggest that at least part of the optical emission has its origin in some of the bright radio features, while the low polarization in optical might be due to the contribution of parts of the radio jet with different orientations of the magnetic field with respect to the optical emission.

Investigating the peculiar emission from the new VHE gamma-ray source H1722+119

The MAGIC (Major Atmospheric Gamma-ray Imaging Cherenkov) telescopes observed the BL Lac object H1722+119 (redshift unknown) for six consecutive nights between 2013 May 17 and 22, for a total of 12.5 h. The observations were triggered by high activity in the optical band measured by the KVA (Kungliga Vetenskapsakademien) telescope. The source was for the first time detected in the very high energy (VHE, E > 100 GeV) γ-ray band with a statistical significance of 5.9 σ. The integral flux above 150 GeV is estimated to be (2.0 ± 0.5) per cent of the Crab Nebula flux. We used contemporaneous high energy (HE, 100MeV < E < 100 GeV) γ-ray observations from Fermi-LAT (Large Area Telescope) to estimate the redshift of the source. Within the framework of the current extragalactic background light models, we estimate the redshift to be z = 0.34±0.15. Additionally, we used contemporaneous X-ray to radio data collected by the instruments on board the Swift satellite, the KVA, and the OVRO (Owens Valley Radio Observatory) telescope to study multifrequency characteristics of the source. We found no significant temporal variability of the flux in the HE and VHE bands. The flux in the optical and radio wavebands, on the other hand, did vary with different patterns. The spectral energy distribution (SED) of H1722+119 shows surprising behaviour in the ∼ 3×1014 −1018 Hz frequency range. It can be modelled using an inhomogeneous helical jet synchrotron self-Compton model.

Intimate Apparel: A Lighting Design

The purpose of this thesis is to provide research, supporting paperwork and production photographs that document the lighting design for the University of Maryland - College Park, School of Theatre, Dance, and Performance Studies’ production of Intimate Apparel, by Lynn Nottage. This thesis contains the following: a design concept statement, research images collected to develop and visually communicate ideas about color, texture, intensity, form, composition and mood to the production team; preliminary and final organization of desired equipment to execute the lighting design; a full set of drafting plates and supplementary paperwork used to communicate the organization and placement of lighting equipment to the master electrician; and magic sheets and cue lists used as organizational tools for the lighting designer during the tech process. Archival production photographs are included as documentation of the completed design.

Le polar de la Caraïbe francophone : enjeux de l’appropriation du genre

Pour minoré et ignoré qu’il fût, le roman policier est désormais légitimé par l’institution littéraire. À parcourir les livres publiés dans la Caraïbe francophone, le genre demeure dans la marge de cette production [issue de la Caraïbe francophone (Haïti, Guadeloupe, Guyane française, Martinique)]. Quoiqu’il en soit, on notera que les années 1990 ont inauguré une véritable éclosion de publications de polars. Tout cela augure d’une acclimatation de ce genre qui ne s’accompagne pas moins de questionnements sur les spécificités éventuelles du polar caribéen francophone. Se situe-t-il dans la convention? Tente-il au contraire d’établir une distanciation avec la norme? C’est pour répondre à ces interrogations que cette thèse se propose d’explorer les enjeux de l’appropriation du polar provenant de cette aire géographique. À l’aune de la poétique des genres, de la sociocritique et de l’intermédialité, un corpus composé de quatorze romans fait l’objet d’une étude approfondie. Dans le premier chapitre, un bref récapitulatif permet de situer les œuvres à l’étude dans l’histoire littéraire du genre tout en soulignant l’adaptation du polar dans la Caraïbe de langue française. Il en ressort qu’un nombre significatif d’écrivains, attentifs à la latence du magico-religieux dans leur société, mettent en scène le surnaturel alors que le roman policier conventionnel plébiscite la méthode logico-déductive. C’est la raison pour laquelle le second chapitre s’intéresse à l’usage de l’inexplicable et son rapport avec le cartésianisme. Quant au troisième chapitre, il se penche sur un topos du genre : la violence telle qu’elle surgit dans ses dimensions commémoratives et répétitives de l’histoire tumultueuse de la Caraïbe. Notre corpus tend à relier la notion du crime, fut-il d’emprise originelle, à l’histoire post-coloniale. Dans la mesure où les personnages constituent un élément clé du genre, ils sont sondés, dans un quatrième chapitre, en regard de la critique sociale qu’ils incarnent et véhiculent. Le dernier chapitre cherche à circonscrire l’intermédialité qui structure et qualifie l’œuvre au sein du roman policier depuis sa genèse. Somme toute, ces divers axes contribuent à mieux comprendre le phénomène de transposition du polar dans cette région du monde.

Do imaginado ao imaginário : magia, improviso e salvação nas narrativas orais tradicionais e nos discursos de formação da Igreja e da religiosidade católica no Brasil

Tese (doutorado)—Universidade de Brasília, Instituto de Ciências Sociais, Departamento de Sociologia, 2016.

The mutable nature of particle-core excitations with spin in the one-valence-proton nucleus Sb-133

The gamma-ray decay of excited states of the one-valence-proton nucleus Sb-133 has been studied using cold-neutron induced fission of U-235 and Pu-241 targets, during the EXILL campaign at the ILL reactor in Grenoble. By using a highly efficient HPGe array, coincidences between gamma-rays prompt with the fission event and those delayed up to several tens of microseconds were investigated, allowing to observe, for the first time, high-spin excited states above the 16.6 mu s isomer. Lifetimes analysis, performed by fast-timing techniques with LaBr3(Ce) scintillators, revealed a difference of almost two orders of magnitude in B(M1) strength for transitions between positive-parity medium-spin yrast states. The data are interpreted by a newly developed microscopic model which takes into account couplings between core excitations (both collective and non-collective) of the doubly magic nucleus Sn-132 and the valence proton, using Skyrme effective interaction in a consistent way. The results point to a fast change in the nature of particle-core excitations with increasing spin. (C) 2016 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license.

Espirito de catimbo: a moral magico-religiosa da jurema

This participative research interested in the social praxis attempts to understand the moral principles that set the magic rituals and the places of worship of three jurema centers of the potiguar region of Canguaretama. Among other inner particularly aspects of each focused catimbó-jurema center, it is being discussed the collective standards involved in the reliance and fellowship values assumed in the private magical gatherings by the juremeiras leaders and their partners, in contrast to the prestige seeking and the individualism that influence both the symbolic competitions and the witchcraft works that link these agents to the broader catimbozeiro universe of this region. Finally, the moral practices which make part of the juremeiro left-right dualism are investigated based on the understanding that the referred native pantheonic-ritual dichotomy does not necessarily express two moralities substantially adversed in terms of benefits or harms, but a series of moral actions subject to the specular logic of the tit-for tat. Thus, this research seeks to prove that this moral structure of symbolic reciprocity, as well as the witchcraft centrality in the catimbozeiro world, finds a certain causal link in a world view which guiding principle is the ontological evil of the catholic cosmology

Potential protective role of reactive astrocytes in the periventricular parenchyma in congenital hydrocephalus

Background Cerebrospinal fluid accumulation in hydrocephalus produces an elevation of intraventricular pressure with pathological consequences on the periventricular brain parenchyma including ischemia, oedema, oxidative stress, and accumulation of metabolic waste products. Here we studied in the hyh mouse, an animal model of congenital hydrocephalus, the role of reactive astrocytes in this clinical degenerative condition. Materials and Methods Wild type and hydrocephalic hyh mice at 30 days of postnatal age were used. Three metabolites related to the oxidative and neurotoxic conditions were analysed in ex vivo samples (glutathione, glutamine and taurine) using High Resolution Magic Angle Spinning (HR-MAS). Glutathione synthetase and peroxidase, glutamine synthetase, kidney-type glutaminase (KGA), and taurine/taurine transporter were immunolocated in brain sections. Results Levels of the metabolites were remarkably higher in hydrocephalic conditions. Glutathione peroxidase and synthetase were both detected in the periventricular reactive astrocytes and neurons. Taurine was mostly found free in the periventricular parenchyma and in the reactive astrocytes, and the taurine transporter was mainly present in the neurons located in such regions. Glutamine synthetase was found in reactive astrocytes. Glutaminase was also detected in the reactive astrocytes and in periventricular neurons. These results suggest a possible protective response of reactive astrocytes against oxidative stress and neurotoxic conditions. Conclusions Astrocyte reaction seems to trigger an anti-oxidative and anti-neurotoxic response in order to ameliorate pathological damage in periventricular areas of the hydrocephalic mice.

Flower abscission and fruit set on table grapes (Vitis vinifera L.): unraveling physiological and molecular mechanisms

Doutoramento em Engenharia Agronómica - Instituto Superior de Agronomia - UL

A cartola mágica : um instrumento de intervenção em perturbações da linguagem

"As perturbações da linguagem apresentam um elevado risco para dificuldades de aprendizagem e podem comprometer a inserção escolar e social das crianças afetadas. Quando a fala não se constitui como um meio de linguagem expressiva, torna-se muito importante proporcionar à criança uma intervenção terapêutica precoce.Com este propósito foi criado um instrumento lúdico-pedagógico para a terapia de fala, capaz de dar suporte conjunto aos cinco domínios linguísticos e que é facilmente apreendido pela criança, favorecendo a sua aprendizagem. O instrumento de intervenção designado por “A Cartola Mágica” é personificado num gato com uma cartola anatomicamente compartimentada em forma de gavetas, simbolizando os cinco domínios da linguagem, destinado a crianças com idades compreendidas entre os 5 e os 8 anos. O instrumento pode ser utilizado em várias vertentes linguísticas, de acordo com os objetivos terapêuticos pretendidos. O instrumento apresenta como limite a portabilidade do modelo criado e, como alcance empírico, o fato de incluir todos os domínios da linguagem e ser de fácil aplicação em settings terapêuticos restritos."

Rostros y rastros del Nobel: Gabriel García Márquez veinticinco años después

Gabriel García Márquez asume la oralidad del homo caribbeans como síntoma de diversidad , por oposición a la universalizante estandarización trascendental de la escritura, en palabras del antillano Edouard Glissant, y representa una reacción a la cultura letrada establecida por el sistema imperial occidental, custodiada por los organismos reguladores del orden establecido en el centro. De este modo, la literatura oficia como archivo cultural. A la luz de la concepción de literatura como escritura, es preferible hablar de diseminación, de intertextualidad, de palimpsesto, en vez de recurrir al trajinado concepto de influencias literarias. En tal sentido, Cien años de Soledad se constituye en un canon emergente, un código maestro, un nuevo mapa cultural que permite múltiples lecturas y re-escrituras. El realismo mágico pone en crisis el concepto aristotélico de mimesis del arte verbal y exige una nueva perspectiva de analisis.Según un importante sector de la critica, la obra garciamarquiana en sus diferentes rostros, desde las tempranas producciones del ciclo Macondiano hasta la Summa Amorosa que concluye con Del amor y otros demonios, señala el tránsito de la narrativa colombiana de la modernidad a la posmodernidad . Por cierto, veinte años después del Nobel, su rastro se puede seguir desde el campo novelístico nacional contemporáneo hasta recónditas geografias literarias del globo. El realismo mágico, así como en general la literatura del boom, constituye desde la década del setenta una nueva fórmula de respuesta a la situación posmoderna, dado que reemplaza el antiguo canon colonial hegemónico y sus ecos esencialistas, realistas y nacionalistas posteriores a la independencia, y proporciona una ficción de autorrepresentación de la realidad híbrida del discurso otro latinoamericano, en la que la categoría de lo maravilloso reemplazará a la de lo sublime. Sin duda, Macondo existe, es una región de la memoria. Pero sus límites no son occidentales. Dentro del mapa literario mundial, es vecino de remotos espacios geolingüísticos y geoculturales.AbstractGabriel García Márquez assumes the oral tradition of the homo caribbeans as a symptom of diversity, by an opposition to the universalizing standardization of writing, to use the words of Antillean writer Edouard Glissant, and represents a reaction against the educated culture established by the Western imperial system and kept by the regulating organisms of the established order in the center. Thus, literature represents a cultural file.Following the notion of literature as writing, it is preferable to talk about dissemination, intertextuality, or palimpsest instead of resorting to the overused concept of literary influences. In this sense, One Hundred Years of Solitude becomes an emerging cannon, a master code, a new cultural map that allows multiple readings and re-writings. Magic realism puts into crisis the Aristotelian concept of mimicry of the verbal art and demands a new perspective of analysis. According to an important sector of critique, the Garciamarquian work– in its different phases, from the early productions of the Macondian cycle to the Summa Amorosa that finishes with Love and Other Demons, represents the path of the colombian narrative from the modernism to postmodernism. By the way, twenty years after the Nobel, its path can be followed from the novel national contemporary field to distant literary geographies of the world. Magic realism, as well as in general terms the literature of the boom, makes from the sixties decade a new form of answering to the postmodern situation, because it substitutes the old colonial hegemonic cannon and its essential , realistic and national voices after the independence. It gives a fiction of sel-frepresentation of the hybrid reality of the other Latin American discourse, in which the marvelous category will replaced that of the sublime. With no doubt, Macondo exists, it is a region of the memory. But its borders are not Western, inside the literary world map, it is a neighbor of remote geolinguistics and geocultural spaces.

Causes of Conversion from Catholicism to Protestantism in Haiti and the role of Vodou after Conversion

The purpose of this thesis was to examine the choice patterns that lead to conversion from Catholicism to Protestantism and the role of Vodou after conversion. This study highlights disappointment with the church as the leading cause of conversion in Haiti. Other causes significant to the study were examined. In illness and healing lie the controversies of religious conversion in Haiti. The only way to cure Satanic Illness is by resorting to magic. However, conversion to Protestantism means rejection of Vodou and all of its practice. A secondary purpose is to determine the role of Vodou after conversion. A total of 100 participants between the ages of 18 to 44 were included in this study. Seven percent (7%) converted for economic reasons, 43% selected disappointment with the church, 17% community/environment encounter, 13% sickness/near death experience, 2% economic and disappointment, 7% community/environment encounter and disappointment with the church, 9% disappointment sickness and near death experience, 1% economic and sickness near death experience, 1% economic and community/environment encounter. Findings suggest that Vodou is deeply rooted in Haitian identity, though all Haitians may not practice Vodou; but there are characteristics in the Haitian society that suggest that Haitians are Vodouisant. For the conversion process to be successful in Haiti it has to deeply acknowledged Vodou, the religion practiced by the masses in Haiti.