Marketing of the Spanish film industry in the entertainment market

This project analyzes the role that marketing plays at present.It is a distinctive in the film industry because of the emergence of new patterns of production, distribution and exhibition due to the unstoppable progress of digital technologies, the expansion of the internet and consumer changes in the spectator. To perform this analysis, a description of the situation of the film industry in the competitive market, Hollywood, and the evolution of digital technology in general are included. It is also essential in the project, to observe, the marketing applied to the different phases of the globalized cinema. And then introduce the potential Spanish marketing strategies.

The Maryland soft shell clam industry and its effects on Tidewater resources

This report to the Maryland General Assembly covers: design and operation of the hydraulic clam dredge; summary of knowledge of Maryland's soft shell clam resource; development and present status; Potential value of the resource; Effects of the hydraulic clam dredge; evaluation of the effects of certain proposals concerning the soft shell clam industry; summary.

Latt-Mayer, um estudo de caso: tecnologia na história do design gráfico brasileiro.

Nosso objetivo neste trabalho é investigar como o design gráfico se relaciona com os meios de produção da indústria gráfica brasileira. Não é comum encontrar referências abordando temas que relacionam design e tecnologia em livros sobre a história do Brasil, o que demonstra a urgência do resgate histórico de indústrias que implementaram novas tecnologias para atender a demandas projetuais e mercadológicas. Sediada na cidade do Rio de Janeiro, a clicheria Latt-Mayer como era comumente chamada, era sinônimo de qualidade e tecnologia. Entre seus clientes podemos apontar agências de publicidade, editoras, escritórios de designers e gráficas de todo país. Esta pesquisa se baseia em um corpus composto por imagens, documentos, manuais técnicos, reportagens, matrizes e depoimentos com pessoas que estiveram diretamente envolvidas com essa empresa. Catalogamos maquinaria e técnicas utilizadas, além de projetos gráficos relevantes que tiveram matrizes e provas produzidas na empresa. Por meio deste trabalho, é possível visualizar um abrangente painel histórico, que contempla um período em que ocorreram significativas transformações na relação entre designers e tecnologia na indústria gráfica brasileira.

Pharmacogenetics of MicroRNAs and MicroRNAs Biogenesis Machinery in Pediatric Acute Lymphoblastic Leukemia

Despite the clinical success of acute lymphoblastic leukemia (ALL) therapy, toxicity is frequent. Therefore, it would be useful to identify predictors of adverse effects. In the last years, several studies have investigated the relationship between genetic variation and treatment-related toxicity. However, most of these studies are focused in coding regions. Nowadays, it is known that regions that do not codify proteins, such as microRNAs (miRNAs), may have an important regulatory function. MiRNAs can regulate the expression of genes affecting drug response. In fact, the expression of some of those miRNAs has been associated with drug response. Genetic variations affecting miRNAs can modify their function, which may lead to drug sensitivity. The aim of this study was to detect new toxicity markers in pediatric B-ALL, studying miRNA-related polymorphisms, which can affect miRNA levels and function. We analyzed 118 SNPs in pre-miRNAs and miRNA processing genes in association with toxicity in 152 pediatric B-ALL patients all treated with the same protocol (LAL/SHOP). Among the results found, we detected for the first time an association between rs639174 in DROSHA and vomits that remained statistically significant after FDR correction. DROSHA had been associated with alterations in miRNAs expression, which could affect genes involved in drug transport. This suggests that miRNA-related SNPs could be a useful tool for toxicity prediction in pediatric B-ALL.