The dexamethasone-induced inhibition of proliferation, migration, and invasion in glioma cell lines is antagonized by macrophage migration inhibitory factor (MIF) and can be enhanced by specific MIF inhibitors.

Glioblastomas (GBMs) are the most frequent and malignant brain tumors in adults. Glucocorticoids (GCs) are routinely used in the treatment of GBMs for their capacity to reduce the tumor-associated edema. Few in vitro studies have suggested that GCs inhibit the migration and invasion of GBM cells through the induction of MAPK phosphatase 1 (MKP-1). Macrophage migration inhibitory factor (MIF), an endogenous GC antagonist is up-regulated in GBMs. Recently, MIF has been involved in tumor growth and migration/invasion and specific MIF inhibitors have been developed on their capacity to block its enzymatic tautomerase activity site. In this study, we characterized several glioma cell lines for their MIF production. U373 MG cells were selected for their very low endogenous levels of MIF. We showed that dexamethasone inhibits the migration and invasion of U373 MG cells, through a glucocorticoid receptor (GR)- dependent inhibition of the ERK1/2 MAPK pathway. Oppositely, we found that exogenous MIF increases U373 MG migration and invasion through the stimulation of the ERK1/2 MAP kinase pathway and that this activation is CD74 independent. Finally, we used the Hs 683 glioma cells that are resistant to GCs and produce high levels of endogenous MIF, and showed that the specific MIF inhibitor ISO-1 could restore dexamethasone sensitivity in these cells. Collectively, our results indicate an intricate pathway between MIF expression and GC resistance. They suggest that MIF inhibitors could increase the response of GBMs to corticotherapy.

Five new associations of parasitoids in potter wasps (Vespidae, Eumeninae)

Five new associations of parasitoids in potter wasps (Vespidae, Eumeninae). New associations of host and parasitoids involving potter wasps: Toxophora leucon and Pleurochrysis sp. were found parasitizing Cyphomenes anisitsii, Chrysis sp. (gr. intricans) was found parasitizing Minixi suffusum, Plega beardi was found parasitizing Montezumia pelagica sepulchralis and Macrosiagon sp. was found parasitizing Pachodynerus nasidens.

La carte à payer, ou L'aubergiste bourgmestre : comédie en un acte, mêlée de vaudevilles / par MM. Merle, Brazier et Carmouche...

Collection : La France dramatique au XIXe siècle

Histoire de la guerre d'Italie. Série 2 / par M. l'abbé Mullois,...

Collection : Bibliothèque de tout le monde

Histoire de la guerre d'Italie. Série 1 / par M. l'abbé Mullois,...

Collection : Bibliothèque de tout le monde

Variabilidade espacial de algumas propriedades químicas e físicas de um solo submetido a diferentes sucessões de cultivo

O presente trabalho foi realizado na Estação Experimental "La Poveda", em Arganda del Rey (Madri) com as seguintes coordenadas geográficas: latitude 40º 19' N; longitude 3º 19' W Gr e altitude de 550 m. O objetivo principal foi estudar a variabilidade espacial de algumas propriedades químicas e físicas de um Typic Xerofluvent submetido a três sistemas de cultivo. Para estudar a variabilidade espacial, a amostragem foi realizada de acordo com um desenho apropriado para a análise geoestatística, em duas direções. Foi observada correlação espacial para o conteúdo de matéria orgânica nos três sistemas estudados. O alcance para o monocultivo da cevada foi de 3 m, enquanto para os sistemas ervilhaca-aveia/girassol e pastagem/ervilhaca-aveia foi de 2 m. Houve menor variação para as propriedades físicas em relação às propriedades químicas, com exceção do conteúdo de areia grossa no monocultivo da cevada. O sistema pastagem/ervilhaca-aveia apresentou-se menos variável com relação ao teor de matéria orgânica.

Pensées sur la religion, par Blaise PASCAL.

Contient : « Récit de deux conférences ou entretiens particuliers, tenus les vendredy premier et mardy cinquième février 1647. » Affaire de Jacques Forton (frère St Ange, Capucin) ; cf. un art. de V. Cousin dans la Bibliothèque de l'École des Chartes, t. IV, p. 111 et suiv ; Correspondance de Pascal et du P. Étienne Noël, jésuite, sur la question du vide. — Copies, auxquelles sont joints deux opuscules imprimés : « Expériences nouvelles touchant le vuide,... par le sieur B. P. » [Pascal]. Paris, 1647, 32 pages, in-8°. — « Lettre de M. Pascal le fils, addressante à M. le premier Président de la Cour des aydes de Clermont-ferrand, sur le subjet de ce qui s'est passé en sa présence, dans le collège des Jésuites de Montferrand, aux thèses de philosophie qui luy ont esté dediées et qui ont esté soubstenuës le 25. juin 1651. » (S. l.), 16 pages, in-4° ; Note sur l'abbaye de Saint-Allyre de Clermont ; Protestations des Pères de l'Oratoire de la maison de S. Honoré, à Paris, de Clermont-Ferrand et de Riom au sujet de l'assemblée générale de la Congrégation (1746) ; Copies de pièces relatives à une prétendue rétractation de Pascal avant sa mort ; Copie de l'épitaphe de Pascal

Les contes du capitaine / par Frédéric Ortoli,... ; dessins de C. Robert Kemp

Collection : Collection Picard