Effect of sodium selenite-enriched reperfusion solutions on rat cardiac ischemia reperfusion injury

Cardiac surgery often generates oxidative stress leading to ischemia reperfusion injury (I-R). Antioxidants have been shown to prevent this injury and have been added to cardioplegic solutions to assist in recovery. In this study, we tested the effectiveness of sodium selenite in protecting against ischemia reperfusion injury and investigated the mechanisms behind this protection. Hearts from male Wistar rats were subjected to ischemia reperfusion using the Langendorf model. Krebs-Henseleit perfusion solutions were supplemented with 0,0.1, 0.5, 1.0, and 10μM sodium selenite. Hearts were perfused for 30 min and then subjected to 22.5 min of global ischemia followed by 45 min reperfusion. Heart rate, ischemic contracture, end diastolic pressure, and developed ventricular pressure were monitored. At the completion of the experiment, hearts were homogenized and tissue extracts were assayed for glutathione peroxidase (GSH-Px) and thioredoxin reductase (Thx-Red) activity. Sodium selenite, at a concentration of 0.5 μM, demonstrated a protective effect on the recovery of cardiac function following I-R, as evidenced by a lower end diastolic pressure and enhanced recovery of rate pressure product. There was no beneficial effect observed in hearts perfused with 0.1 μM sodium selenite-supplemented buffer, whereas poorer functional recovery was observed in hearts perfused with 10 μM sodium selenite-supplemented buffer. The beneficial effect of sodium selenite was not mediated through increased activity of GSH-Px or Thx-Red. This study demonstrates that the addition of sodium selenite to reperfusion solutions, at an optimal concentration of 0.5 μM, assists in cardiac recovery following ischemia reperfusion.

A monotonicity index for the monotone fuzzy modeling problem

In this paper, the problem of maintaining the (global) monotonicity and local monotonicity properties between the input(s) and the output of an FIS model is addressed. This is known as the monotone fuzzy modeling problem. In our previous work, this problem has been tackled by developing some mathematical conditions for an FIS model to observe the monotonicity property. These mathematical conditions are used as a set of governing equations for undertaking FIS modeling problems, and have been extended to some advanced FIS modeling techniques. Here, we examine an alternative to the monotone fuzzy modeling problem by introducing a monotonicity index. The monotonicity index is employed as an approximate indicator to measure the fulfillment of an FIS model to the monotonicity property. It allows the FIS model to be constructed using an optimization method, or be tuned to achieve a better performance, without knowing the exact mathematical conditions of the FIS model to satisfy the monotonicity property. Besides, the monotonicity index can be extended to FIS modeling that involves the local monotonicity problem. We also analyze the relationship between the FIS model and its monotonicity property fulfillment, as well as derived mathematical conditions, using the Monte Carlo method.

The effect of obesity on polycystic ovary syndrome : a systematic review and meta-analysis

While many women with polycystic ovary syndrome (PCOS) are overweight, obese or centrally obese, the effect of excess weight on the outcomes of PCOS is inconsistent. The review aimed to assess the effects of overweight, obesity and central obesity on the reproductive, metabolic and psychological features of PCOS. MEDLINE, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials (CENTRAL) and PSYCINFO were searched for studies reporting outcomes according to body mass index categories or body fat distribution. Data were presented as mean difference or risk ratio (95% confidence interval). This review included 30 eligible studies. Overweight or obese women with PCOS had decreased sex hormone-binding globulin (SHBG), increased total testosterone, free androgen index, hirsutism, fasting glucose, fasting insulin, homeostatic model assessment-insulin resistance index and worsened lipid profile. Obesity significantly worsened all metabolic and reproductive outcomes measured except for hirsutism when compared to normal weight women with PCOS. Overweight women had no differences in total testosterone, hirsutism, total-cholesterol and low-density lipoprotein-cholesterol compared to normal weight women and no differences in SHBG and total testosterone compared to obese women. Central obesity was associated with higher fasting insulin levels. These results suggest that prevention and treatment of obesity is important for the management of PCOS.

The contribution of job and partner satisfaction to the homeostatic defense of subjective wellbeing

Two studies investigate subjective wellbeing (SWB) homeostasis. The first investigates the contribution of job satisfaction (JS) and partner satisfaction (PS) to the homeostatic defense of SWB. The extant model of homeostasis does not include either variable. The second study investigates the relationship between Homeostatically Protected Mood (HPMood) and other factors involved in the homeostatic model. It has been proposed that HPMood is the basic, biologically determined, positive mood that saturates SWB and other related variables, and forms the basis of the SWB set-point. Thus, if HPMood is an individual difference and it perfuses other homeostatic variables, then HPMood should be responsible for much of the shared variance between such variables. Two comparative samples are involved. One is a group of 171 Hong Kong Chinese recruited through convenience sampling. The other is a group of 343 Australians recruited via a general population survey. Results indicate that both JS and PS predict significant variance in Global Life Satisfaction beyond the existing factors in the homeostatic model. It is also found that, after controlling for the effect of HPMood, the strength of correlations between SWB and other homeostatic variables is significantly diminished. The implications of these findings are discussed.

Effect of personal and cultural diversity on outdoor thermal comfort perception

The urban squares are the gathering places where people interact with each other. Therefore, they are seen as important places contributing in the integration and social cohesion within societies. To ensure equality in urban places, designers are to take into considerations the need of the diverse nature of different users. This task is hard especially in global cities where populations are characterized by their cultural plurality. To ensure the creation of successful urban places, the designer is to take the comfort of users into consideration. However, the outdoor thermal comfort is not easily assessed as it examines the climatic and personal variables for users. This paper aims to contribute in assessing the thermal comfort for users of different personal and cultural background in Melbourne city, Australia as one of the global cities characterized by the diversity and plurality of its population due to migration. A case study approach is adopted to examine the users’ thermal comfort within the contextual variables of Federation Square. Multiple sources of evidence such as climate measurements, observations and questionnaires will be used to ensure the validity of results. The findings are to contribute in the quality and equality of design for outdoor urban places in multicultural cities.

Effect of thermal adaptation on outdoor comfort perception

Thermal comfort in outdoor places has proven to have a strong relationship with their users’ attendance and behaviour [1]. Creating comfortable places is therefore to be considered a crucial part of the design process, as taking it into consideration help increasing the social integration between people and therefore fosters sustainability within cities [2]. With the increasing number of migrants within global cities, a new challenge has been facing thermal comfort studies. This challenge is related to the different cultural and climatic origins of those migrants and how they can adapt to the new climatic conditions they are to move in. This paper aims to explore the impact of thermal comfort adaptation on users’ thermal perception in multicultural cities. Consequently, a quantitative field study is applied in Melbourne city, Australia in order to investigate peoples’ outdoor thermal comfort. The analyses were based upon the measurement of climatic parameters that were monitored simultaneously with a questionnaire to determine users’ thermal comfort perception in relation to their time spent in the city. The findings of thermal comfort investigations could be applied into improving the quality of urban areas within global cities and therefore promote the integration within individuals in those societies.

Body mass index and dental caries in children and adolescents : a systematic review of literature published 2004 to 2011

The objective
The authors undertook an updated systematic review of the relationship between body mass index and dental caries in children and adolescents.
Method
The authors searched Medline, ISI, Cochrane, Scopus, Global Health and CINAHL databases and conducted lateral searches from reference lists for papers published from 2004 to 2011, inclusive. All empirical papers that tested associations between body mass index and dental caries in child and adolescent populations (aged 0 to 18 years) were included.
Results
Dental caries is associated with both high and low body mass index.
Conclusion
A non-linear association between body mass index and dental caries may account for inconsistent findings in previous research. We recommend future research investigate the nature of the association between body mass index and dental caries in samples that include a full range of body mass index scores, and explore how factors such as socioeconomic status mediate the association between body mass index and dental caries.

The effect of different doses of an arginine-containing supplement on the healing of pressure ulcers

Objective: To investigate if a lower dose of arginine in the form of an oral nutritional supplement can show similar benefit in the healing rate of pressure ulcers compared with the current evidence for 9g of arginine.

Method: Twenty-three inpatients with category II, III or IV pressure ulcers were randomised to receive daily, for 3 weeks, the standard hospital diet plus 4.5 or 9g arginine in the form of a commercial supplement. Pressure ulcer size and severity was measured weekly (by PUSH tool; pressure ulcer scale for healing; 0= completely healed, 17= greatest severity). Nutritional status was determined by Subjective Global Assessment.

Results: There were no significant differences in patients’ age, gender, BMI, haemoglobin levels, albumin levels and diagnosis of diabetes between treatment groups. There was a significant decrease in pressure ulcer severity over time (p < 0.001), with no evidence of a difference in healing rate between the two arginine dosages (p=0.991). Based on expected healing time, patients in both treatment groups were estimated to achieve an almost 2-fold improvement compared with the historical control group. Patients categorised as malnourished showed clinically significant impaired healing rates compared with wellnourished patients (p=0.057), although this was unaffected by arginine dosage (p=0.727).

Conclusion: Similar clinical benefits in healing of pressure ulcers can be achieved with a lower dosage of arginine, which can translate into improved concordance and significant cost-savings for both the health-care facilities and for patients.

A global heterothermic continuum in mammals

Aim: The ability of endotherms to physiologically regulate body temperature (Tb) is presumed to be important in the adaptive radiation of birds and mammals. Recently, attention has shifted towards determining the extent and energetic significance of Tb variation documented in an ever-expanding list of species. Thus, we provide the first global synthesis of ecological and evolutionary correlates of variation in mammalian Tb. Location: World-wide Methods: We conducted a phylogenetically informed analysis of Tb variation using two complementary metrics, namely Thermoregulatory Scope (TS) and Heterothermy Index (HI), that treat Tb variation as a continuous variable. We included morphological (e.g. body mass), ecological (e.g. food habits) and environmental (e.g. latitude) correlates in the analysis. Results: Among 560 mammal species included in the TS analysis, Tb relates most strongly to body mass (included in all models), season (relative parameter weight: 0.95), absolute latitude (0.80) and hoarding behavior (0.72), with small-bodied, high latitude and non-hoarding species expressing the most Tb variation. Small-bodied and high latitude species also express a greater range of thermoregulatory patterns than large-bodied and low latitude species. Results were generally similar in HI analysis, but in summer the extent of heterothermy decreases with latitude. Main conclusions: Mammalian heterothermy is related to evolutionary history, climate conditions constraining minimum Tb, resource conditions mediating energy supply for maintaining high Tb, and latitudinal variation in the nature of seasonality. Our analysis further shows that traditional classification of mammals as hibernators, daily heterotherms or homeotherms is clouded or possibly misleading.

Creating the Iraq cultural property destruction database: calculating a heritage destruction index

Over the past decade there have been constant reports of damage to significant cultural property in several complex (post-)conflict and (post-)revolutionary states. Recent events in Syria, Mali, Libya, Egypt, Tunisia, Afghanistan and Iraq – as devastating as they have been for people – have also had dramatic consequences for a number of important cultural heritage sites. Despite the severity of these events and global concern, the field of heritage studies has not developed a methodology for cataloguing such heritage destruction in a database. Addressing this paucity in the literature, this article details the methodology developed to produce the Iraq Cultural Property Destruction database, the world’s first database to document the destruction of cultural property in Iraq. This article also documents the calculation of the Heritage Destruction Index – a scale for measuring both the heritage ‘significance’ of a site and the overall level of destruction. Finally, this article also demonstrates the manifold uses of such a database in measuring and monitoring heritage destruction in Iraq. This study therefore sets a significant precedent in heritage studies by providing methods that can be applied to other contexts (past, present and future) to document the destruction of cultural property in complex contexts.

Thai cyber-actors : evidence of an Islamophobic effect

The long-standing Patani Muslim separatist resistance of Southern Thailand is not one that is well known, and its contemporaneous spill over onto the Internet even less so. The more radical Patani online propaganda is in fact symptomatic of the relocation of the struggle within the sphere of influence of global jihadism, distancing itself from the ethno-nationalism characteristic of a previous generation of fighters. New media propaganda, in particular Jihad 2.0, has opened a new sphere of influence to the Patani neojihadist movement, allowing the militants to expand their propaganda campaign to a wider audience, while reaching out to a younger Melayu public. While Jihad 2.0 has presented the resistance movement with new ways to diffuse its message, in a more innovative and appealing manner, it also has enabled it to engage with its audiences more interactively. Because the message is no longer linear, anyone can contribute to the dialectics of the struggle, which in fine results in the alteration and reshaping of its ideological discourse in unprecedented directions. Arguably the ‘glocalisation’ of Islamophobia within Thai culture has resulted in the alteration of the Thai cultural stereotype of the Muslim khaek ‘Other’, transforming the khaek into an evil violent Muslim, both in real and virtual worlds. This further leads to discriminatory attitudes and behaviours towards Muslims, which causes the hardening of the views of the online Patani community of support towards the Thais and possibly its radicalisation.

A test of the resource security and the body mass index reference point hypotheses of body dissatisfaction amongst adolescents in eight countries

Objective. 

Effect of sorghum flour addition on in vitro starch digestibility, cooking quality and consumer acceptability of durum wheat pasta

Whole grain sorghum is a valuable source of resistant starch and polyphenolic antioxidants and its addition into staple food like pasta may reduce the starch digestibility. However, incorporating nondurum wheat materials into pasta provides a challenge in terms of maintaining cooking quality and consumer acceptability. Pasta was prepared from 100% durum wheat semolina (DWS) as control or by replacing DWS with either wholegrain red sorghum flour (RSF) or white sorghum flour (WSF) each at 20%, 30%, and 40% incorporation levels, following a laboratory-scale procedure. Pasta samples were evaluated for proximate composition, in vitro starch digestibility, cooking quality, and consumer acceptability. The addition of both RSF and WSF lowered the extent of in vitro starch digestion at all substitution levels compared to the control pasta. The rapidly digestible starch was lowered in all the sorghum-containing pastas compared to the control pasta. Neither RSF or WSF addition affected the pasta quality attributes (water absorption, swelling index, dry matter, adhesiveness, cohesiveness, and springiness), except color and hardness which were negatively affected. Consumer sensory results indicated that pasta samples containing 20% and 30% RSF or WSF had acceptable palatability based on meeting one or both of the preset acceptability criteria. It is concluded that the addition of wholegrain sorghum flour to pasta at 30% incorporation level is possible to reduce starch digestibility, while maintaining adequate cooking quality and consumer acceptability.

Towards global benchmarking of food environments and policies to reduce obesity and diet-related non-communicable diseases : design and methods for nation-wide surveys

Introduction: