Faces of pricing and profit planning in innovation at the doorstep of the EU:government pricing policy in the pharmaceutical sector in Turkey

The majority of research on the pharmaceutical sector has focused on an overall micro economic, medical oriented welfare issues, whereas the marketing management role of the innovative drug manufacturer has to a large extent been disregarded. Using the case of Turkey, through a series of in-depth interviews with highly innovative companies, other marketing management possibilities are explored based on broader definitions of value and transparency. Our results suggest that pharmaceutical companies as well as the government might have a too narrow focus of value and underestimate the potential long term benefits of a broader approach to marketing management and long term relationships between the various stakeholders.

Industrial districts, inward foreign investment and regional development

This article compares the importance of agglomerations of local firms, and inward FDI as drivers of regional development. The empirical analysis exploits a unique panel dataset of the Italian manufacturing sector at the regional and industry levels. We explore whether FDI and firm agglomeration can be drivers of total factor productivity (separately and jointly), with this effect being robust to different estimators, and different assumptions about inter-regional effects. In particular, we isolate one form of firm agglomeration that is especially relevant in the Italian context, industrial districts, in order to ascertain their impact on productivity. In so doing, we distinguish standard agglomeration and localization economies from industrial districts to understand what additional impact the latter has on standard agglomeration effects. Interaction effects between FDI spillovers and different types of agglomeration economies shed some light on the heterogeneity of regional development patterns as well as on the opportunity to fine tune policy measures to specific regional contexts.

Miami Interpretive Center

The rapid growth and diversity of the City of Miami has left its inhabitants somewhat lost in a city with much to offer. The challenge of this thesis is to provide Miami with an architectural proposal that enhances an understanding of its own urban context through both its form and function. Specifically, the Miami Interpretive Center (M.I.C.) will offer the community a research center for the study of the city, as well as a cultural and exhibition center to allow for the expression of its ever-changing character. With the use of historical context, site relationship and taking advantage of views, the M.I.C. will educate its users towards a better understanding of the city. The goal of the M.I.C. is to establish a center for the continued analysis of the city origins, and growth, while serving as a basis for future initiatives. It will invite the public to seek a new context for the investigation of the natural, urban, cultural, spiritual and political environment that formed the city while participating in the shaping of its future. ^

Rebirth of a neighborhood: In streetscape design

This study involves one of the eight neighborhoods in the City of Miami named Little Havana. Little Havana, once a flourishing Hispanic community during the 1960s through the 1980s, is now experiencing housing deterioration, economic disinvestment, and increased social needs. ^ Although the City developed a Community Development Plan for the neighborhood addressing the neighborhood problems, needs, and objectives, it failed to address and take advantage of the area's prominent commercial street, Calle Ocho, as a cultural catalyst for the revitalization of the neighborhood. With an urban study and understanding of the area's needs for transit system improvements, program analysis, and a valuable architectural inventory, an intervention project can be developed. The project will capitalize on the area's historical and cultural assets and serve as a step towards altering the area's decline and revitalizing the street and community to recapture the energy present during the early years of the massive Cuban migration. ^

Advanced methodologies in dynamic traffic assignment modeling of managed lanes

Managed lane strategies are innovative road operation schemes for addressing congestion problems. These strategies operate a lane (lanes) adjacent to a freeway that provides congestion-free trips to eligible users, such as transit or toll-payers. To ensure the successful implementation of managed lanes, the demand on these lanes need to be accurately estimated. Among different approaches for predicting this demand, the four-step demand forecasting process is most common. Managed lane demand is usually estimated at the assignment step. Therefore, the key to reliably estimating the demand is the utilization of effective assignment modeling processes. ^ Managed lanes are particularly effective when the road is functioning at near-capacity. Therefore, capturing variations in demand and network attributes and performance is crucial for their modeling, monitoring and operation. As a result, traditional modeling approaches, such as those used in static traffic assignment of demand forecasting models, fail to correctly predict the managed lane demand and the associated system performance. The present study demonstrates the power of the more advanced modeling approach of dynamic traffic assignment (DTA), as well as the shortcomings of conventional approaches, when used to model managed lanes in congested environments. In addition, the study develops processes to support an effective utilization of DTA to model managed lane operations. ^ Static and dynamic traffic assignments consist of demand, network, and route choice model components that need to be calibrated. These components interact with each other, and an iterative method for calibrating them is needed. In this study, an effective standalone framework that combines static demand estimation and dynamic traffic assignment has been developed to replicate real-world traffic conditions. ^ With advances in traffic surveillance technologies collecting, archiving, and analyzing traffic data is becoming more accessible and affordable. The present study shows how data from multiple sources can be integrated, validated, and best used in different stages of modeling and calibration of managed lanes. Extensive and careful processing of demand, traffic, and toll data, as well as proper definition of performance measures, result in a calibrated and stable model, which closely replicates real-world congestion patterns, and can reasonably respond to perturbations in network and demand properties.^

Essays on intergenerational and regional aspects of water management

This dissertation consists of three essays on different aspects of water management. The first essay focuses on the sustainability of freshwater use by introducing the notion that altruistic parents do bequeath economic assets for their offspring. Constructing a two-period, over-lapping generational model, an optimal ratio of consumption and pollution for old and young generations in each period is determined. Optimal levels of water consumption and pollution change according to different parameters, such as, altruistic degree, natural recharge rate, and population growth. The second essay concerns water sharing between countries in the case of trans-boundary river basins. The paper recognizes that side payments fail to forge water-sharing agreement among the international community and that downstream countries have weak bargaining power. An interconnected game approach is developed by linking the water allocation issue with other non-water issues such as trade or border security problems, creating symmetry between countries in bargaining power. An interconnected game forces two countries to at least partially cooperate under some circumstances. The third essay introduces the concept of virtual water (VW) into a traditional international trade model in order to estimate water savings for a water scarce country. A two country, two products and two factors trade model is developed, which includes not only consumers and producer's surplus, but also environmental externality of water use. The model shows that VW trade saves water and increases global and local welfare. This study should help policy makers to design appropriate subsidy or tax policy to promote water savings especially in water scarce countries.^

Stable oxygen isotopes in irish oaks: potential for reconstructing local and regional climate

The long Irish oak tree-ring chronology, developed for archaeological dating and radiocarbon calibration, is the longest of any in northwest maritime Europe, spanning most of the Holocene (7,272 years). Unfortunately, the rings widths do not carry a strong climate signal and the record hasnever been satisfactorily applied for dendroclimatic reconstruction. This pilot study explores the potential for extracting a climate signal from Irish oaks by comparing the stable oxygen isotopes ratios from 10 oak tree cores (Quercus robur and Quercus petraea L.) collected across the Armagh region of NE Ireland with local and regional climatic and stable isotopic data. Statistically significant correlations between isotope ratios and the amount of summer precipitation (r = -0.44) point to the isotopic composition of summer rainfall as the dominant signal. Including the Armagh data into an extended regional oxygen isotope series did not reduce the correlation coefficient with regional precipitation (r = -0.68, p < 0.01). Correlations of this magnitude in dendro-hydroclimatology are typically restricted to trees growing at their ecological limits. This research suggests that there is considerable potential for including living trees and ancient timbers from Ireland into a regional composite to reconstruct the summer hydroclimate of Britain and Ireland.

Relational and reproductive trajectories leading to adolescent pregnancy in Portugal: a national and regional characterization

INTRODUCTION: The current study aimed to describe the relational and reproductive trajectories leading to adolescent pregnancy in Portugal, and to explore whether there were differences in this process according to adolescents' place of residence. MATERIAL AND METHODS: Data were collected between 2008 and 2013 in 42 public health services using a self-report questionnaire developed by the researchers. The sample consisted of a nationally representative group of pregnant adolescents (n = 459). RESULTS: Regardless of having had one (59.91%) or multiple sexual partners (40.09%), the majority of adolescents became pregnant in a romantic relationship, using contraception at the time of the conception and knowing the contraceptive failure which led to pregnancy (39.22%). In some regions other trajectories were highly prevalent, reflecting options such as planning the pregnancy (Alentejo Region/ Azores Islands), not using contraception (Centro Region/Madeira Islands) or using it incorrectly, without identifying the contraceptive failure (Madeira Islands). On average, romantic relationships were longer than 19 months and adolescents' partners were older than themselves (> 4 years) and no longer in school (75.16%); these results were particularly significant when the pregnancy was planned. DISCUSSION: The knowledge gained in this study shows that prevention efforts must be targeted according to the adolescents' needs in each region and should include high-risk male groups. CONCLUSION: Our results may enable more efficient health policies to prevent adolescent pregnancy in different country regions and support educators and health care providers on sexual education and family planning efforts.

Cities at risk: status of Italian planning system in reducing seismic and hydrological risks

Italy and its urban systems are under high seismic and hydrogeological risks. The awareness about the role of human activities in the genesis of disasters is achieved in the scientific debate, as well as the role of urban and regional planning in reducing risks. The paper reviews the state of Italian major cities referred to hydrogeological and seismic risk by: 1) extrapolating data and maps about seismic hazard and landslide risk concerning cities with more than 50.000 inhabitants and metropolitan contexts, and 2) outlining how risk reduction is framed in Italian planning system (at national and regional levels). The analyses of available data and the review of the normative framework highlight the existing gaps in addressing risk reduction: nevertheless a wide knowledge about natural risks afflicting Italian territory and an articulated regulatory framework, the available data about risks are not exhaustive, and risk reduction policies and multidisciplinary pro-active approaches are only partially fostered and applied.

Relational and reproductive trajectories leading to adolescent pregnancy in Portugal: a national and regional characterization

INTRODUCTION: The current study aimed to describe the relational and reproductive trajectories leading to adolescent pregnancy in Portugal, and to explore whether there were differences in this process according to adolescents' place of residence. MATERIAL AND METHODS: Data were collected between 2008 and 2013 in 42 public health services using a self-report questionnaire developed by the researchers. The sample consisted of a nationally representative group of pregnant adolescents (n = 459). RESULTS: Regardless of having had one (59.91%) or multiple sexual partners (40.09%), the majority of adolescents became pregnant in a romantic relationship, using contraception at the time of the conception and knowing the contraceptive failure which led to pregnancy (39.22%). In some regions other trajectories were highly prevalent, reflecting options such as planning the pregnancy (Alentejo Region/ Azores Islands), not using contraception (Centro Region/Madeira Islands) or using it incorrectly, without identifying the contraceptive failure (Madeira Islands). On average, romantic relationships were longer than 19 months and adolescents' partners were older than themselves (> 4 years) and no longer in school (75.16%); these results were particularly significant when the pregnancy was planned. DISCUSSION: The knowledge gained in this study shows that prevention efforts must be targeted according to the adolescents' needs in each region and should include high-risk male groups. CONCLUSION: Our results may enable more efficient health policies to prevent adolescent pregnancy in different country regions and support educators and health care providers on sexual education and family planning efforts.

Estudo sócio-ecológico sobre tráfico de seres humanos para fins de exploração laboral na região do Alentejo : análise espacial e estatística

O presente relatório, inserido no Mestrado em Gestão do Território, Área de Especialização em Deteção Remota e Sistemas de Informação Geográfica, lecionado pelo Departamento de Geografia e Planeamento Regional da Faculdade de Ciências Sociais e Humanas da Universidade Nova de Lisboa, pretende descrever o trabalho desenvolvido pelo mestrando enquanto estagiário no Observatório do Tráfico de Seres Humanos (OTSH). O relatório está estruturado em três capítulos distintos. No primeiro capítulo é realizada uma abordagem teórica sobre o Tráfico de Seres Humanos e a distinção entre o mesmo com o Auxílio à Imigração Ilegal. Neste, é também feita uma pequena referência à problemática dos novos fluxos de refugiados/migrantes que, no momento da realização do mesmo, constituem uma questão bastante complexa sobretudo ao nível europeu. No segundo capítulo é realizada uma caracterização da área de estudo, assim como a descrição dos dados utilizados e a metodologia aplicada no mesmo. No terceiro capítulo são apresentados os resultados finais do estudo e a cartografia de síntese que sustenta os mesmos. Para a realização deste estudo recorreu-se a uma análise multicritério em SIG para prever a localização de áreas de maior suscetibilidade de ocorrência de novos casos relativos ao crime do tráfico de seres humanos para exploração laboral na agricultura, na região do Alentejo (distritos de Beja, Évora e Portalegre), através do recurso a dados estatísticos disponibilizados tanto pelo OTSH, como por outras entidades. A metodologia apresentada integra um SIG baseado num modelo raster com o Analytical Hierarchy Process (AHP). Através da realização deste estudo, a importância dos SIG como ferramenta no auxílio ao processo de tomada de decisão, pôde ser testada, conjuntamente com o processo metodológico AHP, através dos resultados apresentados. Com um possível desenvolvimento deste modelo analítico, pretende-se que o mesmo seja adaptável a outras regiões e em última instância, outros tipos de exploração e/ou tráfico.

L’analyse de la vulnérabilité d’une population déplacée suite à un désastre naturel : le cas du site planifié Corail à Port-au-Prince

À travers l’augmentation des désastres dits « naturels » au cours de la dernière décennie, des populations se sont retrouvées soudainement sans maison, sans endroit où loger. L’absence d’endroit où loger amènera donc les populations affectées à se déplacer temporairement et parfois de façon permanente. Cette étude s’intéresse à un cas spécifique de relocalisation dans un site organisé, Corail-Cesselesse, créé quelques mois après le tremblement de terre dévastateur de janvier 2010, en Haïti. Initialement occupé par des ménages provenant surtout des quartiers de Delmas et Port-au-Prince et qui s’étaient réfugiés sur le vaste terrain de golf de Pétionville après avoir perdu leurs habitations, le site de Corail est ainsi étudié de façon descriptive et comparative pour évaluer l’évolution de la vulnérabilité des ménages qui y vivent. Pour ce faire, une revue du concept portant sur la vulnérabilité et la gestion des risques est nécessaire pour y dégager les indicateurs clés servant à l’analyse de l’évolution des états précédant et succédant à une catastrophe naturelle. En particulier, une approche combinant trois méthodes ralliant le qualitatif et quantitatif est utile pour conduire cette évaluation. À travers des questionnaires, des données géospatiales et d’entrevues auprès de professionnels en aménagement dans les pays en développement, on analyse dans quelle mesure la vulnérabilité sociale a évolué. On constate que la prise de décision sur la création de Corail a négligé plusieurs dimensions sociales nécessaires pour permettre aux familles de se rétablir d’un aléa d’une telle amplitude.

L’analyse de la vulnérabilité d’une population déplacée suite à un désastre naturel : le cas du site planifié Corail à Port-au-Prince

À travers l’augmentation des désastres dits « naturels » au cours de la dernière décennie, des populations se sont retrouvées soudainement sans maison, sans endroit où loger. L’absence d’endroit où loger amènera donc les populations affectées à se déplacer temporairement et parfois de façon permanente. Cette étude s’intéresse à un cas spécifique de relocalisation dans un site organisé, Corail-Cesselesse, créé quelques mois après le tremblement de terre dévastateur de janvier 2010, en Haïti. Initialement occupé par des ménages provenant surtout des quartiers de Delmas et Port-au-Prince et qui s’étaient réfugiés sur le vaste terrain de golf de Pétionville après avoir perdu leurs habitations, le site de Corail est ainsi étudié de façon descriptive et comparative pour évaluer l’évolution de la vulnérabilité des ménages qui y vivent. Pour ce faire, une revue du concept portant sur la vulnérabilité et la gestion des risques est nécessaire pour y dégager les indicateurs clés servant à l’analyse de l’évolution des états précédant et succédant à une catastrophe naturelle. En particulier, une approche combinant trois méthodes ralliant le qualitatif et quantitatif est utile pour conduire cette évaluation. À travers des questionnaires, des données géospatiales et d’entrevues auprès de professionnels en aménagement dans les pays en développement, on analyse dans quelle mesure la vulnérabilité sociale a évolué. On constate que la prise de décision sur la création de Corail a négligé plusieurs dimensions sociales nécessaires pour permettre aux familles de se rétablir d’un aléa d’une telle amplitude.

Computed tomography and scintigraphy exams for diagnosis and treatment planning of the condylar osteochondroma: a case report

PURPOSE: To report an uncommon case of osteochondroma affecting the mandibular condyle of a young patient and to illustrate the important contributions of different imaging resources to the diagnosis and treatment planning of this lesion. CASE DESCRIPTION: A 24-year-old female patient with the chief complaint of an increasing facial asymmetry and pain in the left pre-auricular region, revealing a reduced mouth opening, mandibular deviation and posterior cross-bite over a period of 18 months. Panoramic radiography revealed an enlargement of the left condyle, whereas computed tomography (CT) sections and three-dimensional CT showed a well-defined bone growth arising from condylar neck. The scintigraphy exam showed an abnormal osteogenic activity in the left temporomandibular joint. The condyle was surgically removed and after 18 months follow-up the panoramic radiography and CT scans showed no signs of recurrence. CONCLUSION: Although osteochondroma is a benign bone tumor that rarely arises in cranial and maxillofacial region, it should be considered in the differential diagnosis of slow-growing masses of the temporomandibular area and the use of different imaging exams significantly contribute to the correct diagnosis and treatment planning of this pathological condition.