988 resultados para Doença de Von Hippel-Lindau
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It has been suggested that endothelial apoptosis is a primary lesion in the pathogenesis of thrombotic thrombocytopenic purpura (TTP). We tested this hypothesis by examining the phenotypic signatures of endothelial microparticles (EMP) in TTP patients. In addition, the effect of TTP plasma on microvascular endothelial cells (MVEC) in culture was further delineated. EMP released by endothelial cells (EC) express markers of the parent EC; EMP released in activation carry predominantly CD54 and CD62E, while those in apoptosis CD31 and CD105. We investigated EMP release in vitro and in TTP patients. Following incubation of MVEC with TTP plasma, EMP and EC were analysed by flow cytometry for the expression of CD31, CD51, CD54, CD62E, CD105, CD106 and von Willebrand factor (VWF) antigen. EMP were also analysed in 12 TTP patients. In both EC and EMP, CD62E and CD54 expression were increased 3- to 10-fold and 8- to 10-fold respectively. However, CD31 and CD105 were reduced 40-60% in EC but increased twofold in EMP. VWF expression was found in 55 +/- 15% of CD62E(+) EMP. Markers of apoptosis were negative. In TTP patients, CD62E(+) and CD31(+)/CD42b(-) EMP were markedly elevated, and preceded and correlated well with a rise in platelet counts and a fall in lactate dehydrogenase. CD62E(+) EMP (60 +/- 20%) co-expressed VWF and CD62E. The ratio of CD31(+)/42b(-) to CD62E(+) EMP exhibited a pattern consistent with activation. In conclusion, our studies indicate endothelial activation in TTP. EMP that co-express VWF and CD62E could play a role in the pathogenesis of TTP.
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2010
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2009
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O greening, inicialmente chamado de "doenças do ramo amarelo", e posteriomente huanglonbing (HBL), doença do dragão amarelo, é considerada a doença dos citros de maior importância no mundo, em função da dificuldade de controle, da rápida disseminação e por ser altamente destrutiva. O primeiro relato da doença foi feito da China, em 1919, espalhando-se daí para países da África e Oceania. No início do século 21, foi detectada no continente americano, exatamente nos dois países e estados maiores produtores de citros: os Estados Unidos (Flórida) e o Brasil (São Paulo) onde foi relatada em Araraquara em 2004, estando hoje em mais de 100 municípios produtores.
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1993
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2009
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Acesso em: 17 nov. 2003.
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Morfologia da espigueta do sorgo; Suscetibilidade do progenitor feminino; Biologia do florescimento; Estadios da doenca; Formacao do estroma, Gota-de-mel, conidios e esclerocios; Ciclo da doenca e relacao patogeno-hospedeiro; Efeito dos exsudatos aderentes nas sementes; Disseminacao por insetos; Efeito de fertilizantes sobre a incidencia da doenca; Periodos latentes, de esporulacao e severidade; Identificacao de linhagens resistentes; Hospedeiros alternativos; Manejo integrado do Ergot.
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2004
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2004
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Williams, H. and Wischke, M. (2004). Zwischen Widerstandsrecht und starkem Staat. Ein Beitrag zur deutschen Rezeptionsgeschichte von Hobbes. In K. Graf Ballestrem, V. Gerhardt, H. Ottmann and M. Thompson, Politisches Denken. Jahrbuch 2004 (pp.25-42). Berlin: Duncker & Humblot.
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Gohm, Rolf; Skeide, M., (2005) 'Constructing extensions of CP-maps via tensor dilations with rhe help of von Neumann modules', Infinite Dimensional Analysis, Quantum Probability and Related Topics 8(2) pp.291-305 RAE2008
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This article attempts to qualify the work with authentic source material such as TV news in foreign language teaching. At first, the role of authentic materials in foreign language teaching shall be discussed. Afterwards, TV news will be briefly examined and characterized from the point of view of media theory. Methodic-didactic considerations on the work with TV news in class round up the article.