Functional connectivity in BOLD and CBF data: similarity and reliability of resting brain networks

Resting-state functional connectivity (FC) fMRI (rs-fcMRI) offers an appealing approach to mapping the brain's intrinsic functional organization. Blood oxygen level dependent (BOLD) and arterial spin labeling (ASL) are the two main rs-fcMRI approaches to assess alterations in brain networks associated with individual differences, behavior and psychopathology. While the BOLD signal is stronger with a higher temporal resolution, ASL provides quantitative, direct measures of the physiology and metabolism of specific networks. This study systematically investigated the similarity and reliability of resting brain networks (RBNs) in BOLD and ASL. A 2×2×2 factorial design was employed where each subject underwent repeated BOLD and ASL rs-fcMRI scans on two occasions on two MRI scanners respectively. Both independent and joint FC analyses revealed common RBNs in ASL and BOLD rs-fcMRI with a moderate to high level of spatial overlap, verified by Dice Similarity Coefficients. Test-retest analyses indicated more reliable spatial network patterns in BOLD (average modal Intraclass Correlation Coefficients: 0.905±0.033 between-sessions; 0.885±0.052 between-scanners) than ASL (0.545±0.048; 0.575±0.059). Nevertheless, ASL provided highly reproducible (0.955±0.021; 0.970±0.011) network-specific CBF measurements. Moreover, we observed positive correlations between regional CBF and FC in core areas of all RBNs indicating a relationship between network connectivity and its baseline metabolism. Taken together, the combination of ASL and BOLD rs-fcMRI provides a powerful tool for characterizing the spatiotemporal and quantitative properties of RBNs. These findings pave the way for future BOLD and ASL rs-fcMRI studies in clinical populations that are carried out across time and scanners.

Undergraduate palliative care teaching in Swiss medical faculties: a nationwide survey and improved learning objectives

BACKGROUND In 2007, a first survey on undergraduate palliative care teaching in Switzerland has revealed major heterogeneity of palliative care content, allocation of hours and distribution throughout the 6 year curriculum in Swiss medical faculties. This second survey in 2012/13 has been initiated as part of the current Swiss national strategy in palliative care (2010 - 2015) to serve as a longitudinal monitoring instrument and as a basis for redefinition of palliative care learning objectives and curriculum planning in our country. METHODS As in 2007, a questionnaire was sent to the deans of all five medical faculties in Switzerland in 2012. It consisted of eight sections: basic background information, current content and hours in dedicated palliative care blocks, current palliative care content in other courses, topics related to palliative care presented in other courses, recent attempts at improving palliative care content, palliative care content in examinations, challenges, and overall summary. Content analysis was performed and the results matched with recommendations from the EAPC for undergraduate training in palliative medicine as well as with recommendations from overseas countries. RESULTS There is a considerable increase in palliative care content, academic teaching staff and hours in all medical faculties compared to 2007. No Swiss medical faculty reaches the range of 40 h dedicated specifically to palliative care as recommended by the EAPC. Topics, teaching methods, distribution throughout different years and compulsory attendance still differ widely. Based on these results, the official Swiss Catalogue of Learning Objectives (SCLO) was complemented with 12 new learning objectives for palliative and end of life care (2013), and a national basic script for palliative care was published (2015). CONCLUSION Performing periodic surveys of palliative care teaching at national medical faculties has proven to be a useful tool to adapt the national teaching framework and to improve the recognition of palliative medicine as an integral part of medical training.

Cognition and Student Learning Through the Arts

An increasing number of recent research studies suggest connections between cognition, social and emotional development, and the arts. Some studies indicate that students in schools where the arts are an integral part of the academic program tend to do better in school than those students where that is not the case. This study examines home/school factors that contribute most to variance in student learning and achievement and the arts from over 8,000 students in grade 5. The findings suggest in-school arts programs may have less of an impact on student achievement than proposed by previous research.

Color data, carbon and oxygen isotopes, and offsets from BBCP Polecat Bench cores 2A and 2B

The Earth's climate abruptly warmed by 5-8 °C during the Palaeocene-Eocene thermal maximum (PETM), about 55.5 million years ago**1,2. This warming was associated with a massive addition of carbon to the ocean-atmosphere system, but estimates of the Earth systemresponse to this perturbation are complicated by widely varying estimates of the duration of carbon release, which range from less than a year to tens of thousands of years. In addition the source of the carbon, and whether it was released as a single injection or in several pulses, remains the subject of debate**2-4. Here we present a new high-resolution carbon isotope record from terrestrial deposits in the Bighorn Basin (Wyoming, USA) spanning the PETM, and interpret the record using a carbon-cycle boxmodel of the ocean-atmosphere-biosphere system.Our record shows that the beginning of the PETMis characterized by not one but two distinct carbon release events, separated by a recovery to background values. To reproduce this pattern, our model requires two discrete pulses of carbon released directly to the atmosphere, at average rates exceeding 0.9 Pg C yr**-1, with the first pulse lasting fewer than 2,000 years.

Spicule dimensions of Siphonodictyon spp., raw data, biometry and frequency distributions

Early descriptions for species of Aka were poor in detail, and the only spicule type that occurs in this genus does not vary much between species, which led to taxonomic confusion. Moreover, the type specimens of 5 species of Aka are lost, causing considerable problems. Mediterranean specimens of Aka were identified as Aka labyrinthica (Hancock, 1849) by Topsent (1900), even though this species was originally described from the Indo-Pacific. All following publications on Mediterranean Aka accepted Topsent's decision. We assessed this problem with new samples from the Ionian Sea. Our material consisted of only one specimen of Aka, and we had to rely mainly on spicule characters for comparison to other species. We developed a system for species recognition solely based on spicular characters and biometry, involving a combination of the parameters oxea length, width, tip form and angle of curvature. This approach was surprisingly accurate. Forming ratios of the above parameters was less helpful, but can sometimes provide additional information. We identified our sample as Aka infesta (Johnson, 1899), and describe it as a minute-fistulate species with large, multicamerate erosion traces and stout, smooth oxeas. Our data further imply that A. labyrinthica sensu Hancock has not yet been found in the Mediterranean. A. labyrinthica sensu Topsent is a collection of different species not including A. labyrinthica sensu Hancock.

X-ray fluorescence data (calcium and iron), bulk organic d13C, and dinoflagellate cysts of ODP Hole 189-1172D

The 'Paleocene/Eocene Thermal Maximum' or PETM (~55 Ma) was associated with dramatic warming of the oceans and atmosphere, pronounced changes in ocean circulation and chemistry, and upheaval of the global carbon cycle. Many relatively complete PETM sequences have by now been reported from around the world, but most are from ancient low- to midlatitude sites. ODP Leg 189 in the Tasman Sea recovered sediments from this critical phase in Earth history at Sites 1171 and 1172, potentially representing the southernmost PETM successions ever encountered (at ~70° to 65° S paleolatitude). Downhole and core logging data, in combination with dinoflagellate cyst biostratigraphy, magneto-stratigraphy, and stable isotope geochemistry indicate that the sequences at both sites were deposited in a high accumulation-rate, organic rich, marginal marine setting. Furthermore, Site 1172 indeed contains a fairly complete P-E transition, whereas at Site 1171, only the lowermost Eocene is recovered. However, at Site 1172, the typical PETM-indicative acme of the dinocyst Apectodinium was not recorded. We conclude that unfortunately, the critical latest Paleocene and PETM intervals are missing at Site 1172. We relate the missing section to a sea level driven hiatus and/or condensed section and recovery problems. Nevertheless, our integrated records provide a first-ever portrait of the trend toward, and aftermath of, the PETM in a marginal marine, southern high-latitude setting.

Profile of sediment echo sounding with links to ParaSound data files and swath sonar multibeam bathymetry during METEOR cruise M70/2b

Two highly active mud volcanoes located in 990-1,265 m water depths were mapped on the northern Egyptian continental slope during the BIONIL expedition of R/V Meteor in October 2006. High-resolution swath bathymetry and backscatter imagery were acquired with an autonomous underwater vehicle (AUV)-mounted multibeam echosounder, operating at a frequency of 200 kHz. Data allowed for the construction of ~1 m pixel bathymetry and backscatter maps. The newly produced maps provide details of the seabed morphology and texture, and insights into the formation of the two mud volcanoes. They also contain key indicators on the distribution of seepage and its tectonic control. The acquisition of high-resolution seafloor bathymetry and acoustic imagery maps with an AUV-mounted multibeam echosounder fills the gap in spatial scale between conventional multibeam data collected from a surface vessel and in situ video observations made from a manned submersible or a remotely operating vehicle.